This chapter outlines the articulations and actions of Muslim NGOs with a special focus on their instrumentalization of Islamic social finance instruments, namely sadaqa or voluntary almsgiving and donations and zakat or mandatory almsgiving in contemporary sub-Saharan Africa. Zakat constitutes a form of vertical philanthropy in all cases above as it is formal, structuralized and institutionalized. Sadaqa, in turn, corresponds to horizontal philanthropy as it is organized through private, personalized and informal ways, commonly through self-help groups or mosque funds. However, there has been an expansion of vertical forms of philanthropy during the last decade due to the establishment of private foundations, trusts and corporate foundations by High Net-Worth Individuals or ‘Muslim entrepreneurs’ as well as community chests and foundations in many sub-Saharan countries. Various studies estimate that zakat amounts from USD 200 billion to USD 1 trillion per annum across the world or around USD 187 million among countries in the Organisation of Islamic Cooperation (OIC). Therefore, not only Muslim states but also Muslim NGOs have turned their interest to mobilize zakat for poverty alleviation in Muslim majority countries as well as for international development and humanitarian projects.