Human Seminal Plasma Contains a Protein that Shares Physicochemical, Immunochemical, and Immunosuppressive Properties with Pregnancy-Associated Plasma Protein-A*

Bischof, P.; Martin-Du-Pan, Rémy C; Lauber, K; Girard, Jean‐Pierre; Herrmann, Walter; Sizonenko, Pierre C.

doi:10.1210/jcem-56-2-359

Cited by 50 publications

(16 citation statements)

References 13 publications

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“…The observed correlation between PAPP-A and inhibition of lymphocyte transformation agrees with our previous data: removing PAPP-A-like material from seminal plasma reduced the inhibitory effect of seminal plasma on PHA-induced lymphocyte transformation [5]. It is interesting to note that for an unexplained reason, in vasectomized men, PAPP-A and lymphocyte transformation inhibition are no longer correlated.…”

Section: Discussionsupporting

confidence: 90%

Immunosuppressive Activity of Seminal Plasma and Pregnancy-Associated Plasma Protein-A (PAPP-A) in Men

Martin-Du-Pan¹,

Bischof²,

Bourrit³

et al. 1983

Archives of Andrology

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Pregnancy-associated plasma protein-A (PAPP-A) and inhibition of phytohemagglutinin (PHA)-induced lymphocyte transformation were measured in 5 I seminal plasma samples obtained from oligozoospermic (n = 22), normospermic ( n = 22). and vasectomized men (n = 7 ) . In nonvasectomized men, PAPP-A significantly correlated with the percentage inhibition of lymphocyte transformation. The possibility of PAPP-A being an immunosuppressive principle of human seminal plasma is discussed.

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Section: Discussionsupporting

confidence: 90%

Immunosuppressive Activity of Seminal Plasma and Pregnancy-Associated Plasma Protein-A (PAPP-A) in Men

Martin-Du-Pan¹,

Bischof²,

Bourrit³

et al. 1983

Archives of Andrology

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“…The performances of the different models were evaluated by Receiver Operating Characteristic (ROC) curve analysis with estimation of areas under the curve (AUROC). The quality-of-fit of models was assessed using r 2 and AIC (Akaike Information Criterion) [27]. Specificity, sensitivity, and predictive values were obtained for the logistic regression models.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Pregnancy Associated Plasma Protein (PAPP-A) is an important glycoprotein found in maternal blood that increases as pregnancy progresses [1], although it is not specific to pregnancy [2,3]. In pregnancy, PAPP-A is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Association of low levels of first trimester Pregnancy Associated Plasma Protein (PAPP-A) with adverse pregnancy outcomes: An observational study

Ranganathan¹,

Fresen²,

Sarkar³

2017

Obstet Gynecol Rep

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Objectives: To explore the effects of low levels of first trimester Pregnancy Associated Plasma Protein-A (PAPP-A) on adverse pregnancy outcomes.Design: Single centre retrospective observational study. Setting: District general hospital.Population: Women with singleton pregnancies with low PAPP-A, attending Heatherwood and Wexham Park Hospital for first trimester combined screening for Down syndrome.Methods: Data was collected from Astraia Database and CMiS maternity system. Multiple linear regression models for birth weight and gestational age at delivery were developed after adjusting for confounding variables. Logistic regressions were dichotomised for preterm delivery into <34 weeks and ≥ 34 weeks, birth weight centiles, into <10 th centile and ≥10 th centile, and pre-eclampsia versus no pre-eclampsia. Main outcome measures:Preterm birth, small for gestational age (SGA) and pre-eclampsia.Results: PAPP-A levels of ≤0.4MoM is associated with SGA <10 th centile at p=0.04 with a positive predictive value (PPV) of 83.3% and negative predictive value (NPV) of 79.3%. Similarly, association with preterm birth <34 weeks is also significant at p=0.05 with PPV of 66% and NPV of 87.4%. A significant association with pre-eclampsia (p=0.6) could not be identified. In our study data of PAPP-A ≤0.4 MoM, for every 0.1MoM fall in PAPP-A, there was a reduction in birth weight by 78gm and an earlier birth by 5.3 days. Conclusion:There is an increased likelihood of preterm delivery and SGA with progressive reduction of PAPP-A levels below ≤0.4 MoM.

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“…These include zinc, in both free and complex form [8], prostaglandin E (PGE) [7], uteroglobin and transglu taminase [9], spermine and spermidine [10], preg nancy-associated plasma protein A [11] and unchar acterized high molecular weight (HMW) substances [2,3,12]. It has been suggested that these factors pro tect sperm from immunological damage in the male, and prevent sensitization of the female to sperm anti gens after insemination.…”

Section: Introductionmentioning

confidence: 99%

Human Seminal Plasma Suppresses Delayed-Type Hypersensitivity Responses to Intravaginally Deposited Sheep Red Blood Cells and Sperm: Separation of Immunosuppressive Factors

Lee

Ha²

1989

Int Arch Allergy Immunol

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Although significant progress has been made in identifying the immunosuppressive factors in seminal plasma (SP) and their possible action in vitro, the potential role of SP in naturally occurring normal immune responses in vivo is less certain. Human SP or its fractions, administered 5 or 10 times at 3-day intervals into the mouse vagina simultaneously with washed human sperm or sheep red blood cells, suppressed the delayed-type hypersensitivity reactions to footpad injection of the antigens. However, SP failed to suppress antibody formation to these antigens in the applied experimental conditions. In an in vitro study, SP suppressed the proliferation of human peripheral blood mononuclear cells to phytohemagglutinin. This suppression of in vitro proliferation by SP was mediated by materials of both low (LMW) and high molecular weight (HMW). Among the HMW materials, a factor with approximately 1,500 kilodaltons, partially purified by DEAE-cellulose chromatography and gel filtration, exhibited the most potent suppressor activity in vitro and in vivo. The suppressive activities of SP or its fractions were not abolished by treatment with both heat (95 °C for 10 min) and trypsin (1.0 mg/ml, 37 °C for 4 h). These findings indicate that SP could contribute to the development of suppressed cellular immunity to sperm; immunosuppressive actions of SP are mediated by at least two distinct factors in vivo as well as in vitro.

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Human Seminal Plasma Contains a Protein that Shares Physicochemical, Immunochemical, and Immunosuppressive Properties with Pregnancy-Associated Plasma Protein-A*

Cited by 50 publications

References 13 publications

Immunosuppressive Activity of Seminal Plasma and Pregnancy-Associated Plasma Protein-A (PAPP-A) in Men

Immunosuppressive Activity of Seminal Plasma and Pregnancy-Associated Plasma Protein-A (PAPP-A) in Men

Association of low levels of first trimester Pregnancy Associated Plasma Protein (PAPP-A) with adverse pregnancy outcomes: An observational study

Human Seminal Plasma Suppresses Delayed-Type Hypersensitivity Responses to Intravaginally Deposited Sheep Red Blood Cells and Sperm: Separation of Immunosuppressive Factors

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