Human serum albumin: spectroscopic studies of the paclitaxel binding and proximity relationships with cisplatin and adriamycin

Separate and simultaneous binding effects of aspirin and amlodipine to human serum albumin based on fluorescence spectroscopic and molecular modeling characterizations: A mechanistic insight for determining usage drugs doses

“…Recent studies have shown that HSA is able to bind multiple ligands in several binding sites [72]. Six binding sites for various ligands were found in the HSA structure and drugs usually bind with high affinity to sites I and II [4].…”

Application of solid-phase microextraction in the investigation of protein binding of pharmaceuticals

“…The percentage of binding to human plasma proteins for the other studied pharmaceuticals is reported to be: 40% for ciprofloxacin, 92% for haloperidol, 92% for nortriptyline, 88-98% for paclitaxel and 87% for quinidine [22]. The binding of paclitaxel to HSA has been the subject of investigations for the identification of the binding site and binding constant but also aiming towards the development of water soluble paclitaxel formulations in the form of albumin conjugates [23][24][25][26].…”

Investigation of effects of newly synthesized Pt(II) complex against human serum albumin and leukemia cell line of K562

“…Some properties of HSA, like as well as its preferential uptake in tumor and inflamed tissue, its ready availability, its biodegradability, and its lack of toxicity and immunogenicity make it an ideal candidate for drug delivery (11,12). The degree of binding between a drug and plasma proteins can govern its distribution into tissues, affect its elimination from the body, and, consequently, affect its therapeutic or toxic effects.…”