This study establishes the evaluation index system of Chengdu’s habitat suitability based on three dimensions (the ecological livability environment, economic development environment, and social security environment) and quantitatively investigates the habitat suitability of Chengdu using the Analytic Hierarchy Process (AHP) and ArcGIS10.8 tools. Additionally, it analyzes the spatial pattern characteristics of Chengdu’s habitat suitability to provide insights into the rational optimization of Chengdu’s habitat system, and show that (1) the adaptability index of Chengdu’s human settlement is between 18.39 to 92.35, and the habitat suitability exhibits a high spatial distribution in the central area and a low spatial distribution in the surrounding regions, with obvious differences between hot spots and cold spots. (2) According to the suitability index from high to low, the habitat of Chengdu is divided into five regions: the most suitable area (895.62 km2, 6.25%), highly suitable area (2136.82 km2,14.91%), moderately suitable area (5755.80 km2,40.15%), low-suitability area (4580.61 km2, 31.95%) and the unsuitable area (966.15 km2, 6.74%). (3) The spatial distribution of habitat suitability in Chengdu demonstrates a certain coupling relationship with the city’s circular social development model. Moreover, the spatial distribution characteristics of each area exhibit good consistency with population density, natural environment, economic conditions, and social conditions. (4) The influence of each indicator factor shows spatial heterogeneity, with variations in different subregions. Additionally, different regions have their own advantages and disadvantages. The results show that there are obvious regional characteristics with the suitability of human settlements in Chengdu; the main urban area exhibits the highest degree of habitat suitability, while the western Longmen Mountain area shows relatively lower suitability in its habitat. Considering these spatial characteristics, future development should explore corresponding development modes for each region based on local conditions, aiming to reduce spatial differences and promote the integrated development of urban and rural areas.