Human/Simian Immunodeficiency Virus Transmission and Infection at Mucosal Sites

Berzofsky, Jay A.; Franchini, Genoveffa

doi:10.1016/b978-0-12-415847-4.00075-6

Mucosal Immunology 2015

DOI: 10.1016/b978-0-12-415847-4.00075-6

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Human/Simian Immunodeficiency Virus Transmission and Infection at Mucosal Sites

Jay A. Berzofsky

Genoveffa Franchini

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2023

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References 138 publications

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HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria

Planchais,

Molinos-Albert,

Rosenbaum

et al. 2023

Nat Commun

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HIV-1 infection causes severe alterations of gut mucosa, microbiota and immune system, which can be curbed by early antiretroviral therapy. Here, we investigate how treatment timing affects intestinal memory B-cell and plasmablast repertoires of HIV-1-infected humans. We show that only class-switched memory B cells markedly differ between subjects treated during the acute and chronic phases of infection. Intestinal memory B-cell monoclonal antibodies show more prevalent polyreactive and commensal bacteria-reactive clones in late- compared to early-treated individuals. Mirroring this, serum IgA polyreactivity and commensal-reactivity are strongly increased in late-treated individuals and correlate with intestinal permeability and systemic inflammatory markers. Polyreactive blood IgA memory B cells, many of which egressed from the gut, are also substantially enriched in late-treated individuals. Our data establish gut and systemic B-cell polyreactivity to commensal bacteria as hallmarks of chronic HIV-1 infection and suggest that initiating treatment early may limit intestinal B-cell abnormalities compromising HIV-1 humoral response.

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HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria

Planchais,

Molinos-Albert,

Rosenbaum

et al. 2023

Nat Commun

View full text Add to dashboard Cite

show abstract

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Human/Simian Immunodeficiency Virus Transmission and Infection at Mucosal Sites

Cited by 1 publication

References 138 publications

HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria

HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria

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