1996
DOI: 10.1016/0305-4179(95)00119-0
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Human skin histology as demonstrated by Herovici's stain: a guide for the improvement of dermal substitutes for use with cultured keratinocytes?

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Cited by 12 publications
(9 citation statements)
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“…By day 28, the collagen has matured into thicker yellow and organized bundles in the treated tissue, while the control samples were still found to have predominantly re-growing thinner unorganized collagen fibers. It is worth mentioning that Herovici stain is generally used to differentiate young and mature collagen and this stain colors mature dense collagen red while newly formed collagen are colored blue [3840]). Herovici staining on day 28 samples (remodeling phase) further confirmed the formation of organized mature collagen in the wounds treated with SSD–CSM-ASC-FPEG (S2C and S2D Fig).…”
Section: Resultsmentioning
confidence: 99%
“…By day 28, the collagen has matured into thicker yellow and organized bundles in the treated tissue, while the control samples were still found to have predominantly re-growing thinner unorganized collagen fibers. It is worth mentioning that Herovici stain is generally used to differentiate young and mature collagen and this stain colors mature dense collagen red while newly formed collagen are colored blue [3840]). Herovici staining on day 28 samples (remodeling phase) further confirmed the formation of organized mature collagen in the wounds treated with SSD–CSM-ASC-FPEG (S2C and S2D Fig).…”
Section: Resultsmentioning
confidence: 99%
“…3f,g ). This stain labels mature fibrillar collagen pink and immature collagen blue 19 . Both IPI4182-treated and untreated telogen dermis had a preponderance of mature collagen, whereas untreated dermis of mice with epidermal β-catenin activation had a high proportion of immature collagen, as reported previously 6 ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…To visualize and analyze the distribution of dermal collagen we performed classic histochemical stainings based on Herovici’s protocol, which stains collagen dark pink (mature [collagen type I]) and blue (young [collagen type III]) in human and mouse skin ( Collins et al., 2011 , Fitzgerald et al., 1996 , Watt and Fujiwara, 2011 ). Whereas the amount of young collagen (blue) over time was quite comparable in both mouse genotypes, the amount of mature collagen (dark pink) was significantly increased in the skin of MMP-14 Sf–/– compared with control mice ( Figure 5 ).…”
Section: Resultsmentioning
confidence: 99%