2015
DOI: 10.1016/j.mce.2015.06.019
|View full text |Cite
|
Sign up to set email alerts
|

Human somatostatin receptor-3 distinctively induces apoptosis in MCF-7 and cell cycle arrest in MDA-MB-231 breast cancer cells

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
13
0

Year Published

2016
2016
2023
2023

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 22 publications
(14 citation statements)
references
References 71 publications
1
13
0
Order By: Relevance
“…HPV16 genomic integration sites in the human genome were detected at the intronic/upstream/downstream region of certain genes associated with cancer. For example: the LAMA3 gene, splice variant of which are known to be involved in tumor cell invasion and progression in head and neck squamous cell carcinoma 63 ; the ATXN10, whose gene product is a downstream effector of the p53-p21 and p16-pRB tumor suppressor pathways 64 ; the IL12RB2 gene, whose expression is known to be upregulated in OCSCC 65 ; the cell polarity regulator gene INADL, de-regulation of which has been associated with cancer 66 ; the ABCA10 gene, known to be downregulated in many cancers 67 ; the WDR89 gene, which is seen to be associated with many cancers; the EPHA6, known to be associated with prostate cancer progression 68 ; the ncRNA FAM35BP 69 and LOC100506207 70 , insertion at the vicinity of these ncRNA region may influence their expression as has been reported for several HPV16 integration sites in the vicinity of numerous miRNAs 58 ; the tumor suppressor SPECC1 and IL12RB2 mutations are associated with epithelial cancers 71 ; the amino acid transporter gene SLC7A7, dysregulation of which is associated with multiple cancers 72 ; the pro-apoptotic tumor suppressor SSTR3 gene 73 ; the RAC2 gene, linked to different cancers including head and neck cancer 74 ; the SLC13A3 gene associated with enhanced metastasis 75 ; the DLGAP1 gene, shown to be associated with OCSCC 76 ; the PAFAH1B1 gene, a potential oncogene in lung cancer 77 and the oncogene MKLN1 associated with different cancers 78 . Therefore we have detected distribution of HPV16 integration sites throughout the genome, many of which have the potential to functionally alter critical cellular gene expression through integration.…”
Section: Discussionmentioning
confidence: 97%
“…HPV16 genomic integration sites in the human genome were detected at the intronic/upstream/downstream region of certain genes associated with cancer. For example: the LAMA3 gene, splice variant of which are known to be involved in tumor cell invasion and progression in head and neck squamous cell carcinoma 63 ; the ATXN10, whose gene product is a downstream effector of the p53-p21 and p16-pRB tumor suppressor pathways 64 ; the IL12RB2 gene, whose expression is known to be upregulated in OCSCC 65 ; the cell polarity regulator gene INADL, de-regulation of which has been associated with cancer 66 ; the ABCA10 gene, known to be downregulated in many cancers 67 ; the WDR89 gene, which is seen to be associated with many cancers; the EPHA6, known to be associated with prostate cancer progression 68 ; the ncRNA FAM35BP 69 and LOC100506207 70 , insertion at the vicinity of these ncRNA region may influence their expression as has been reported for several HPV16 integration sites in the vicinity of numerous miRNAs 58 ; the tumor suppressor SPECC1 and IL12RB2 mutations are associated with epithelial cancers 71 ; the amino acid transporter gene SLC7A7, dysregulation of which is associated with multiple cancers 72 ; the pro-apoptotic tumor suppressor SSTR3 gene 73 ; the RAC2 gene, linked to different cancers including head and neck cancer 74 ; the SLC13A3 gene associated with enhanced metastasis 75 ; the DLGAP1 gene, shown to be associated with OCSCC 76 ; the PAFAH1B1 gene, a potential oncogene in lung cancer 77 and the oncogene MKLN1 associated with different cancers 78 . Therefore we have detected distribution of HPV16 integration sites throughout the genome, many of which have the potential to functionally alter critical cellular gene expression through integration.…”
Section: Discussionmentioning
confidence: 97%
“…When expressed in stable rat pituitary tumor cells (GC cells), human SST 3 exhibits constitutive ligand-independent activity that inhibits basal cAMP/protein kinase A (PKA) signaling and suppresses GH transcription through glycogen synthase kinase 3B activation ( Eigler et al, 2014 ). Heterologously expressed SST 3 also induces antiproliferative or proapoptic cell-specific effects ( War et al, 2015 ). SST 3 -induced apoptosis in CHO-K1 cells involves induction of transformation-related protein 53 (p53) and Bax ( Sharma et al, 1996 ).…”
Section: Somatostatin Receptormentioning
confidence: 99%
“…Heterologous SSTs expression was also reported to induce pro-apoptotic effects [62]. In particular, this was shown for SST 3 , which, when expressed in CHO-K1 cells, causes the activation of the apoptosis-related proteins p53 and Bax [63].…”
Section: Introductionmentioning
confidence: 99%