Human‐specific CHRFAM7A primes macrophages for a heightened pro‐inflammatory response at the earlier stage of inflammation
Rui Zhou,
Keran Niu,
Chaoying Wang
et al.
Abstract:Abstractα7‐Nicotinic acetylcholine receptor (α7‐nAChR) is the key effector molecule of the cholinergic anti‐inflammatory pathway. Evolution has evolved a uniquely human α7‐nAChR encoded by CHRFAM7A. It has been demonstrated that CHRFAM7A dominant negatively regulates the functions of α7‐nAChR. However, its role in inflammation remains to be fully characterized. CHRFAM7A transgenic (Tg) mice were phenotypically normal and their peritoneal macrophages exhibited decreased ligand‐binding capability and, importantl… Show more
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