Human sperm acrosomal status, acrosomal responsiveness, and acrosin are predictive of the outcomes of in vitro fertilization: A prospective cohort study

Xu, Fang; Zhu, Hailun; Zhu, Wenbing; Fan, Lu

doi:10.1016/j.repbio.2018.10.007

Cited by 15 publications

(10 citation statements)

References 54 publications

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“…Several studies have shown decreased SAA levels in infertile men [20,21]. Xu et al investigated the relationship between SAA and IVF fertilization rate, and found that patients with low SAA levels (< 25 uIU/10 6 ) had signi cantly lower fertilization rate than those with relatively high SAA levels (≥ 25 uIU/10 6 ) [13]. Acrosin represents a series of trypsin-like serine proteinases within the acrosome of human spermatozoa [22,23].…”

Section: Discussionmentioning

confidence: 99%

“…Although some male factors are generally thought to be relevant to LFR/TFF, how to apply these parameters for TFF/LFR prediction and treatment decision making remains an issue to be solved. Numerous univariate analyses have been performed on male factors such as age, sperm quality, normal sperm morphology rate (NSMR), sperm acrosin activity (SAA) and sperm DNA fragmentation index (DFI) to determine their relationship with the success of in vitro fertilization [10][11][12][13]. Chapuis et al reported that low progressive motility (PR), e.g., below 32%, had a signi cant negative impact on in vitro fertilization, leading to a decreased fertilization rate and a low number of viable embryos at day 2.…”

Section: Introductionmentioning

confidence: 99%

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Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate

Lin

Wang

et al. 2023

Preprint

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Objective Low fertilization rate (LFR) and total fertilization failure (TFF) are often encountered in routine IVF procedure. To solve this problem, multivariate analyses on the relationship between male factors and in vitro fertilization rate were performed, and a nomogram for prediction of LFR was constructed. Methods This retrospective study contained 2,011 couples who received IVF treatment from January 2017 to December 2021. Man clinical characteristics, laboratory test results, in vitro fertilization rate were collected. Results A total of 2,011 couples underwent IVF were analyzed. Among these couples, 1,347 cases had in vitro fertilization rates ≥ 30% (control group), and 664 cases had in vitro fertilization rates < 30% (low fertilization rate (LFR) group). Univariate analyses of male factors found that between the two groups there were significant differences (p<0.05) in sperm progressive motility (SPR), sperm concentration (SC), total sperm number, normal sperm morphology rate (NSMR), DFI, sperm acrosin activity (SAA) and the clinical diagnosis of primary or secondary infertility, but not in blood glucose level, MBI, and semen volume. Multivariate logistic regression analyses showed that SPR, SAA, and SC were independent risk factors for LFR. An algorithm and a corespondent nomogram for predicting high LFR risk were constructed using data from the training cohort. The LFR nomogram exhibited an excellent discrimination power and a high fitting degree in both the training cohort (AUC = 0.90, 95% CI: 0.88 - 0.92), (H-L: x2 = 5.43, p = 0.71) and validation cohort (AUC = 0.89, 95% CI:0.87 - 0.92), (H-L: x2 = 7.85, p = 0.45), respectively. The decision curve analysis (DCA) demonstrated a high efficiency of the LFR nomogram for clinical utility. Conclusions SPR, SAA, and SC are independent risk factors for LFR. The LFR nomogram established based on these factors could be a useful tool to predict high risk of LFR, and patients with high risk of LFR can be guided to direct ICSI procedure. Clinical application of the LFR nomogram may increase the in vitro fertilization rate by facilitating the decision making in IVF service.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate

Lin

Wang

et al. 2023

Preprint

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“…The decreased energy production suggests a possible deregulation in the metabolic profile of asthenozoospermic men. Moreover, spontaneous acrosomal reaction negatively correlates with progressive sperm motility [51][52][53]. The acrosomal state and function are important aspects of gamete interaction during the fertilization process.…”

Section: Discussionmentioning

confidence: 99%

Male Age and Progressive Sperm Motility Are Critical Factors Affecting Embryological and Clinical Outcomes in Oocyte Donor ICSI Cycles

Vogiatzi¹,

Pouliakis

Σακελλαρίου³

et al. 2021

Reprod. Sci.

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This retrospective cohort study aimed to explore whether paternal age and semen quality parameters affect the embryological and clinical outcomes of ICSI with oocyte donation. A total of 339 oocyte donation (OD)-ICSI cycles were categorized into four groups according to the semen parameter profiles of the male counterparts: normozoospermia (NS, n = 184), oligozoospermia (OS, n = 41), asthenozoospermia (AS, n = 50), and oligoasthenozoospermia (OAS, n = 64). The effect of age, total sperm count, and progressive motility was separately analyzed for reproductive outcomes and compared between the study groups: fertilization, blastulation, and top-quality embryo rate, biochemical and clinical pregnancy, live birth, and miscarriage. A negative correlation between male age and fertilization rate was observed (r s = − 0.23, p < 0.0001), while male age was a significant factor for biochemical pregnancy (p = 0.0002), clinical pregnancy (p = 0.0017), and live birth (p = 0.0038). Reduced total sperm count and lowered progressive motility led to poorer fertilization rates (r s = 0.19 and 0.35, respectively, p < 0.0001) and affected embryo quality (r s = 0.13, p = 0.02, and r s = 0.22, p < 0.0001, respectively). OD-ICSI cycles with asthenozoospermia had significantly lowered success rates in biochemical pregnancy, clinical pregnancy, and live birth (p < 0.05). Our study demonstrated that both advanced male age and reduced progressive motility of spermatozoa exert a significant negative influence on the outcome of assisted reproduction, even in controlled procedures with gamete selection and optimization such as in OD-ICSI. Improvement in treatment strategies and male fertility evaluation requires incorporation of such evidence to obtain better prognosis towards personalized management.

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“…In another 2018 study, Xu and colleagues (2) examined the utility of the AR test to predict fertilization in 485 couples undergoing conventional in vitro fertilization (IVF). The authors found that the percentage of sperm exhibiting spontaneous AR in neat semen predicted fertilization rates (FR).…”

Section: Tests Evaluating Sperm Fertilizing Abilitymentioning

confidence: 99%

Are specialized sperm function tests clinically useful in planning assisted reproductive technology?

Esteves

2020

Int. braz j urol.

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40-year-old male patient and 32-year-old female partner, with a history of primary infertility of two years duration. The workup revealed idiopathic mild oligoasthenotheratozoospermia, and no apparent female infertility factors. The couple has failed three intrauterine insemination (IUI) cycles, planning more IUI cycles but also considering in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI).

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Human sperm acrosomal status, acrosomal responsiveness, and acrosin are predictive of the outcomes of in vitro fertilization: A prospective cohort study

Cited by 15 publications

References 54 publications

Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate

Multivariate analyses on male factors and construction of a nomogram for predicting low in vitro fertilization rate

Male Age and Progressive Sperm Motility Are Critical Factors Affecting Embryological and Clinical Outcomes in Oocyte Donor ICSI Cycles

Are specialized sperm function tests clinically useful in planning assisted reproductive technology?

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