Human Spermatogenesis and Its Regulation

Chen, Haiqi; Mruk, Dolores D.; Xiao, Xiang; Cheng, C. Yan

doi:10.1007/978-3-319-53298-1_3

Cited by 28 publications

(32 citation statements)

References 223 publications

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“…During the divisions described above, the cells migrate from the basal membrane of seminiferous tubules towards the lumen. Spermatids undergo a complex cytodifferentiation, during which active gene transcription ceases, the chromatin is remodelled, and the assembly of sperm flagellum occurs to form spermatozoa that will ultimately be released from the seminiferous epithelium via a process known as spermiation [ 86 , 87 ].…”

Section: Emf Effects In Male Reproductive System and Fertilitymentioning

confidence: 99%

Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems

Santini

Cordone

Falone

et al. 2018

Oxidative Medicine and Cellular Longevity

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Modern technologies relying on wireless communication systems have brought increasing levels of electromagnetic field (EMF) exposure. This increased research interest in the effects of these radiations on human health. There is compelling evidence that EMFs affect cell physiology by altering redox-related processes. Considering the importance of redox milieu in the biological competence of oocyte and sperm, we reviewed the existing literature regarding the effects of EMFs on reproductive systems. Given the role of mitochondria as the main source of reactive oxygen species (ROS), we focused on the hypothesis of a mitochondrial basis of EMF-induced reproductive toxicity. MEDLINE, Web of Science, and Scopus database were examined for peer-reviewed original articles by searching for the following keywords: “extremely low frequency electromagnetic fields (ELF-EMFs),” “radiofrequency (RF),” “microwaves,” “Wi-Fi,” “mobile phone,” “oxidative stress,” “mitochondria,” “fertility,” “sperm,” “testis,” “oocyte,” “ovarian follicle,” and “embryo.” These keywords were combined with other search phrases relevant to the topic. Although we reported contradictory data due to lack of uniformity in the experimental designs, a growing body of evidence suggests that EMF exposure during spermatogenesis induces increased ROS production associated with decreased ROS scavenging activity. Numerous studies revealed the detrimental effects of EMFs from mobile phones, laptops, and other electric devices on sperm quality and provide evidence for extensive electron leakage from the mitochondrial electron transport chain as the main cause of EMF damage. In female reproductive systems, the contribution of oxidative stress to EMF-induced damages and the evidence of mitochondrial origin of ROS overproduction are reported, as well. In conclusion, mitochondria seem to play an important role as source of ROS in both male and female reproductive systems under EMF exposure. Future and more standardized studies are required for a better understanding of molecular mechanisms underlying EMF potential challenge to our reproductive system in order to improve preventive strategies.

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Section: Emf Effects In Male Reproductive System and Fertilitymentioning

confidence: 99%

Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems

Santini

Cordone

Falone

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Herein, we briefly review these recent data to provide a molecular model regarding the regulation of BTB dynamics by the local area regulatory networks besides the hormonal hypothalamic-pituitary-testicular axis [40–44] which have been reviewed by other investigators.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Blood-Testis Barrier (BTB) Dynamics, Role of Actin-, and Microtubule-Based Cytoskeletons

Wen

Tang

et al. 2018

Methods in Molecular Biology

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The blood-testis barrier (BTB) is an important ultrastructure in the testis that supports meiosis and postmeiotic spermatid development since a delay in the establishment of a functional Sertoli cell barrier during postnatal development in rats or mice by 17–20 day postpartum (dpp) would lead to a delay of the first wave of meiosis. Furthermore, irreversible disruption of the BTB by toxicants also induces infertility in rodents. Herein, we summarize recent findings that BTB dynamics (i.e., disassembly, reassembly, and stabilization) are supported by the concerted efforts of the actin- and microtubule (MT)-based cytoskeletons. We focus on the role of two actin nucleation protein complexes, namely, the Arp2/3 (actin-related protein 2/3) complex and formin 1 (or the formin 1/spire 1 complex) known to induce actin nucleation, respectively, by conferring plasticity to actin cytoskeleton. We also focus on the MT plus (+)-end tracking protein (+TIP) EB1 (end-binding protein 1) which is known to confer MT stabilization. Furthermore, we discuss in particular how the interactions of these proteins modulate BTB dynamics during spermatogenesis. These findings also yield a novel hypothetical concept regarding the molecular mechanism that modulates BTB function.

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“…In addition, maturing spermatids and spermatozoa are extremely vulnerable to oxidative stress, implying a need for a well-balanced iron homeostasis in the seminiferous tubule [14]. This may partially justify the high concentrations of this protein in seminal plasma.…”

Section: Resultsmentioning

confidence: 99%

Seminal Ferritin And Seminal Parameters In Patients Undergoing Chronic Hemodialysis

2017

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Background: to verify the association of seminal parameter (SP) and seminal ferritin (SF) levels in patients undergoing chronic hemodialysis (CH), admitting possible antioxidative activity of SF.Methods: This was a case-control study in group of 60 men (case) in CH with more than 6 months and group of healthy men (control), aged 18-60 years, without clinical or laboratory signs of infection/ inflammation. Patients underwent semen analysis, fertility index (FI) calculation, measurement of SF and hormonal profile (follicle-stimulating hormone, luteinizing hormone, total testosterone, and prolactin levels).Results: There were significant differences between cases and control (Table 1) Conclusion:The results suggest that SF is not associated with changes in seminal parameters in patients undergoing chronic hemodialysis, and is not useful singly for initial evaluation of seminal parameters.

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Human Spermatogenesis and Its Regulation

Cited by 28 publications

References 223 publications

Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems

Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems

Regulation of Blood-Testis Barrier (BTB) Dynamics, Role of Actin-, and Microtubule-Based Cytoskeletons

Seminal Ferritin And Seminal Parameters In Patients Undergoing Chronic Hemodialysis

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