2021
DOI: 10.1038/s41577-020-00474-y
|View full text |Cite
|
Sign up to set email alerts
|

Human stem cell models to study host–virus interactions in the central nervous system

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
38
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
7
2
1

Relationship

1
9

Authors

Journals

citations
Cited by 41 publications
(38 citation statements)
references
References 161 publications
0
38
0
Order By: Relevance
“…The vulnerability of particular cell types in the developing brain and the impact on brain health and function require further study and human stem cell-derived neural models are a tractable method to evaluate viral tropism (23). Data from cerebral organoids, which are reflective of developmental stages, suggest that in vitro neurons may be vulnerable to SARS-CoV-2 infection.…”
mentioning
confidence: 99%
“…The vulnerability of particular cell types in the developing brain and the impact on brain health and function require further study and human stem cell-derived neural models are a tractable method to evaluate viral tropism (23). Data from cerebral organoids, which are reflective of developmental stages, suggest that in vitro neurons may be vulnerable to SARS-CoV-2 infection.…”
mentioning
confidence: 99%
“…Advancements in hPSC-technology allow for the study of host-virus interactions in human, disease-relevant cells 16 . Recent studies using hPSC-derived organoid models have established that choroid plexus cells within the CNS are highly susceptible to SARS-CoV-2 infection 17,18 .…”
Section: )mentioning
confidence: 99%
“…SARS-CoV-2 infection, tropism, and potential treatments were examined in human organoids of the lung, liver, intestine, blood vessels, and kidney [196][197][198]. Currently, human brain organoids are being developed to study the pathophysiological aspects associated with SARS-CoV-2-induced alterations in the brain [198,199]. These organoids are useful to study the early stages of neuronal development during COVID-19 infection.…”
Section: Sars-cov-2 and Models Of Brain Organoidsmentioning
confidence: 99%