Human stem memory T cells (TSCM) as critical players in the long-term persistence of immune responses

Morrot, Alexandre

doi:10.21037/atm.2017.02.28

Cited by 9 publications

(7 citation statements)

References 6 publications

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“…T SCM cells have great potential in overcoming the limitations of current T cell-based immunotherapy (22)(23)(24). In mouse tumor models and human hematopoietic stem cell transplantation (HSCT) patients, T SCM cells have higher antitumor activity and survival rate.…”

Section: Introductionmentioning

confidence: 99%

Immunotherapeutic Potential of T Memory Stem Cells

Yang

et al. 2021

Front. Oncol.

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Memory T cells include T memory stem cells (TSCM) and central memory T cells (TCM). Compared with effector memory T cells (TEM) and effector T cells (TEFF), they have better durability and anti-tumor immunity. Recent studies have shown that although TSCM has excellent self-renewal ability and versatility, if it is often exposed to antigens and inflammatory signals, TSCM will behave as a variety of inhibitory receptors such as PD-1, TIM-3 and LAG-3 expression, and metabolic changes from oxidative phosphorylation to glycolysis. These changes can lead to the exhaustion of T cells. Cumulative evidence in animal experiments shows that it is the least differentiated cell in the memory T lymphocyte system and is a central participant in many physiological and pathological processes in humans. It has a good clinical application prospect, so it is more and more important to study the factors affecting the formation of TSCM. This article summarizes and prospects the phenotypic and functional characteristics of TSCM, the regulation mechanism of formation, and its application in treatment of clinical diseases.

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Section: Introductionmentioning

confidence: 99%

Immunotherapeutic Potential of T Memory Stem Cells

Yang

et al. 2021

Front. Oncol.

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“…With the progression of T-cell exhaustion, the therapeutic efficacy of antitumor immunotherapy becomes limited, resulting in persistent infections and leading to inefficient cancer control ( 102 ). Some T cells exhibit stem cell-like characteristics that are believed to be the key to triggering a robust, long-lasting antitumor response ( 27 , 28 , 103 ). By using the graft-versus-host disease mouse model, Zhang et al.…”

Section: T-cell Stemnessmentioning

confidence: 99%

T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

Chi

Luo²,

Ye³

et al. 2023

Front. Immunol.

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T cells play a crucial role in the regulation of immune response and are integral to the efficacy of cancer immunotherapy. Because immunotherapy has emerged as a promising treatment for cancer, increasing attention has been focused on the differentiation and function of T cells in immune response. In this review, we describe the research progress on T-cell exhaustion and stemness in the field of cancer immunotherapy and summarize advances in potential strategies to intervene and treat chronic infection and cancer by reversing T-cell exhaustion and maintaining and increasing T-cell stemness. Moreover, we discuss therapeutic strategies to overcome T-cell immunodeficiency in the tumor microenvironment and promote continuous breakthroughs in the anticancer activity of T cells.

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“…T memory stem cells (Tscm), endowed with self-renewal and multipotent properties, are vital for immunity and successful immunotherapy responses [1][2][3][4][5][6][7][8][9] . Gattinoni et al 6 first described canonical human Tscm cells, which express CCR7 (or CD62L), CD45RA, CD95, are CD45RO negative, and express other markers indicative of early memory 6 .…”

Section: Mainmentioning

confidence: 99%

A CD45RO+ stem cell memory T cell population intermediate to canonical stem cell memory and central memory T cells in human cancer.

Powell

Eiva

Brown

et al. 2022

Preprint

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T memory stem cells (Tscm) are integral for effective immunotherapy and antitumor responses, but little is known about Tscm immunobiology in solid human tumors. Here we identify self-renewing and multipotent Tscm tumor-infiltrating lymphocytes (TILs) in human cancer and present a novel Tscm subset which expresses CD45RO, is derived from CD45RO- Tscm T cells, and is capable of self-renewal and multipotency. From the analysis of CD45RO+ Tscm differentiation, phenotyping, gene expression, and the broader TCR repertoire, we find CD45RO+ Tscm cells are hierarchically positioned in between canonical CD45RO- Tscm cells and central memory T cells. Notably, CD45RO+ Tscm cells exhibit a gene expression profile with effector capabilities and a tumor-specific phenotype that is more similar to T cells associated with successful immunotherapy than canonical Tscm. Overall, we identify a novel Tscm subset in human cancer which has distinct phenotypic, transcriptional, and effector-like attributes that position it as an attractive subset for future research in the setting of cancer immunotherapy.

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Human stem memory T cells (TSCM) as critical players in the long-term persistence of immune responses

Cited by 9 publications

References 6 publications

Immunotherapeutic Potential of T Memory Stem Cells

Immunotherapeutic Potential of T Memory Stem Cells

T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

A CD45RO+ stem cell memory T cell population intermediate to canonical stem cell memory and central memory T cells in human cancer.

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