Human Studies of Cannabinoids and Medicinal Cannabis

Robson, Philip

doi:10.1007/3-540-26573-2_25

Cited by 58 publications

(59 citation statements)

References 120 publications

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“…Cannabis had been used in ancient Greece, Rome, China, and India for relieving muscle cramps, spasm, and pain (reviewed in Mechoulam, 1986Mechoulam and Hanus, 2000) and its therapeutic application in MS is a topic of recent lively debate (Grundy, 2002;Pertwee, 2002;Baker and Pryce, 2003;Croxford, 2003;Killestein et al, 2004;Sirven and Berg, 2004;Jackson et al, 2005a;Pryce and Baker, 2005;Robson, 2005;Smith, 2005). Lyman et al (1989) examined the effects of parenteral THC in experimental autoimmune encephalomyelitis (EAE) in rats, a laboratory model of MS. THC treatment not only reduced CNS inflammation and improved neurological outcome but also improved survival compared with placebo.…”

Section: Central Nervous System Disordersmentioning

confidence: 99%

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

2006

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Section: Central Nervous System Disordersmentioning

confidence: 99%

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

2006

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“…The medicinal use of cannabis (marijuana), currently one of the most frequently used recreational drugs, dates back to 2600 BCE (Mechoulam and Hanus, 2000;Robson, 2005). Clinical agents based on marijuana's principal psychoactive cannabinoid, ⌬ 9 -tetrahydrocannabinol (⌬ 9 -THC), were developed before our current understanding of the molecular mechanism of ⌬ 9 -THC action.…”

Section: A Marijuana and Cannabinoidsmentioning

confidence: 99%

Oxidation of the Endogenous Cannabinoid Arachidonoyl Ethanolamide by the Cytochrome P450 Monooxygenases: Physiological and Pharmacological Implications

2010

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“…To date, cannabinoids have been successfully used in the treatment of nausea and vomiting [18], two common side effects that accompany chemotherapy in cancer patients. Nevertheless, the use of cannabinoids in oncology might be somehow underestimated since increasing evidence exist that plant, synthetic, and endogenous cannabinoids (endocannabinoids) are able to exert a growth inhibitory action on various cancer cell types.…”

Section: Introductionmentioning

confidence: 99%

<i>In Vitro</i> Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines

Sharma¹,

Hudson²,

Adomat³

et al. 2014

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Cannabinoids, the active components of Cannabis sativa Linnaeus, have received renewed interest in recent years due to their diverse pharmacologic activities such as cell growth inhibition, anti-inflammatory effects and tumor regression, but their use in chemotherapy is limited by their psychotropic activity. To date, cannabinoids have been successfully used in the treatment of nausea and vomiting, two common side effects that accompany chemotherapy in cancer patients. Most non-THC plant cannabinoids e.g. cannabidiol and cannabigerol, seem to be devoid of psychotropic properties. However, the precise pathways through which these molecules produce an antitumor effect have not yet been fully characterized. We therefore investigated the antitumor and anti-inflammatory activities of cannabidiol (CBD) in human prostate cancer cell lines LNCaP, DU145, PC3, and assessed whether there is any advantage in using cannabis extracts enriched in cannabidiol and low in THC. Results obtained in a panel of prostate cancer cell lines clearly indicate that cannabidiol is a potent inhibitor of cancer cell growth, with significantly lower potency in non-cancer cells. The mRNA expression level of cannabinoid receptors CB1 and CB2, vascular endothelial growth factor (VEGF), PSA (prostate specific antigen) are significantly higher in human prostate cell lines. Treatment with Cannabis extract containing high CBD down regulates CB1, CB2, VEGF, PSA, pro-inflammatory cytokines/chemokine IL-6/IL-8. Our overall findings support the concept that cannabidiol, which lacks psychotropic activity, may possess anti-inflammatory property and down regulates both cannabinoid receptors, PSA, VEGF, IL-6 and IL-8. High CBD cannabis extracts are cytotoxic to androgen responsive LNCaP cells and may effectively inhibit spheroid formation in cancer stem cells. This activity may contribute to its anticancer and chemosensitizing effect against prostate cancer. Cannabidiol and other non-habit forming cannabinoids could be used as novel therapeutic agents for the treatment of prostate cancer.

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Human Studies of Cannabinoids and Medicinal Cannabis

Cited by 58 publications

References 120 publications

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

Oxidation of the Endogenous Cannabinoid Arachidonoyl Ethanolamide by the Cytochrome P450 Monooxygenases: Physiological and Pharmacological Implications

<i>In Vitro</i> Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines

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Human Studies of Cannabinoids and Medicinal Cannabis

Cited by 58 publications

References 120 publications

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

Oxidation of the Endogenous Cannabinoid Arachidonoyl Ethanolamide by the Cytochrome P450 Monooxygenases: Physiological and Pharmacological Implications

&lt;i&gt;In Vitro&lt;/i&gt; Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines

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<i>In Vitro</i> Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines