Human sweat odour conjugates in human milk, colostrum and amniotic fluid

Hartmann, Constanze; Doucet, Sébastien; Niclass, Yvan; Dittrich, Ralf; Cupisti, S.; Schaal, Benoı̂st; Buettner, Andrea; Starkenmann, Christian

doi:10.1016/j.foodchem.2012.04.077

Cited by 9 publications

(7 citation statements)

References 36 publications

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“…From these analyses, varieties of compounds that are odorous to the adult were identified, but so far, none of them were tested with infants. Colostrum, which is much more difficult to sample in quantity for both ethical and practical reasons, underwent much rarer chemical dissections of its volatiles (Hartmann et al, 2012; Loos et al, 2019; Macy, 1949). These last studies found odorous compounds that are inclusive to colostrum and later‐lactation milk, although in graded quantities.…”

Section: Discussionmentioning

confidence: 99%

“…First , as the fluid that inaugurates postnatal ingestion, colostrum is a key transitional medium from the fetus to the neonate. Despite compositional differences with amniotic fluid, colostrum is chemically overlapping with it (Hartmann et al, 2012; Schaal, 2016), prompting odor resemblance between both substrates and equivalent attraction in newborns (Marlier, Schaal, & Soussignan, 1997; Schaal, Marlier, & Soussignan, 1998). Secondly , and related to the previous point, the chemosensory familiarity of colostrum is probably higher in the days right after birth, during the phase of colostral stability (ie, postnatal days 0–2; Patton, Huston, Montgomery, & Josephson, 1986; Montgomery, Patton, Huston, & Josephson, 1987).…”

Section: Introductionmentioning

confidence: 99%

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Human neonates prefer colostrum to mature milk: Evidence for an olfactory bias toward the “initial milk”?

Klaey-Tassone

Durand

Damon

et al. 2020

American J Hum Biol

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Objectives Colostrum is the initial milk secretion which ingestion by neonates warrants their adaptive start in life. Colostrum is accordingly expected to be attractive to newborns. The present study aims to assess whether colostrum is olfactorily attractive for 2‐day‐old newborns when presented against mature milk or a control. Methods The head‐orientation of waking newborns was videotaped in three experiments pairing the odors of: (a) colostrum (sampled on postpartum day 2, not from own mother) and mature milk (sampled on average on postpartum day 32, not from own mother) (n tested newborns = 15); (b) Colostrum and control (water; n = 9); and (c) Mature milk and control (n = 13). Results When facing the odors of colostrum and mature milk, the infants turned their nose significantly longer toward former (32.8 vs 17.7% of a 120‐s test). When exposed to colostrum against the control, they responded in favor of colostrum (32.9 vs 16.6%). Finally, when the odor of mature milk was presented against the control, their response appeared undifferentiated (26.7 vs 28.6%). Conclusions These results indicate that human newborns can olfactorily differentiate conspecific lacteal fluids sampled at different lactation stages. They prefer the odor of the mammary secretion ‐ colostrum ‐ collected at the lactation stage that best matches the postpartum age of their own mother. These results are discussed in the context of the earliest mother‐infant chemo‐communication. Coinciding maternal emission and offspring reception of chemosignals conveyed in colostrum may be part of the sensory precursors of attunement between mothers and infants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Human neonates prefer colostrum to mature milk: Evidence for an olfactory bias toward the “initial milk”?

Klaey-Tassone

Durand

Damon

et al. 2020

American J Hum Biol

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“…By directly comparing colostrum and mature milk samples, higher methylamine concentrations were detected in colostrum [63]. Similarly, Hartmann et al [71] detected amino acid conjugates of human sweat odorants in colostrum and milk samples, with higher concentrations in colostrum. Yet, these analyses did not include olfactometry, and the relative impact of the detected odorous compounds on the overall odour of colostrum remains to be elucidated.…”

Section: Lactational Stagementioning

confidence: 93%

“…Indeed, various volatile compounds occur in milk, with important inter-and intra-individual qualitative and quantitative variations [1,[61][62][63][64][65][66][67][68][69][70]. Further, amino acid conjugates known as precursors of sweat odour have been detected in milk [71], and might analogously contribute to milk odour after cleavage. The present review, however, focuses on those milk volatiles that are perceivable by an adult human nose, as determined via gas chromatography-olfactometry/mass spectrometry (GC-O/MS; [72,73]).…”

Section: Odorous Volatiles Of Milkmentioning

confidence: 99%

The odour of human milk: Its chemical variability and detection by newborns

Loos

Reger

Schaal

2019

Physiology & Behavior

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Human milk odour has for long elicited research interest with regard to its function in breastfeeding initiation. The present review aims to provide an overview of the behavioural effects of human milk odour in the human neonate, considering different types of response measures in a feeding or nonfeeding context. Further, an overview of the current knowledge of odorant composition and factors influencing milk odour is provided by summarizing results from analytical studies using olfactometry, and addressing changes in milk odour due to storage, lactational stage, and maternal dietary intake of odorous substances. We finally highlight some issues for future research.

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“…Since then, various studies have been performed to further explore the role of 3H3MH, 3M3SH and their precursors. The effect of the genetic background on odour secretion was studied with a twin study, gender differences in releasing precursors for acids and thiols were investigated, and finally the relationship with human leucocyte antigen and detection in human milk and amniotic fluid were explored. Recently, it was found that the gene ABCC11 is crucial for the formation of the characteristic odour, and Martin et al .…”

Section: Axillary Malodoursmentioning

confidence: 99%

Review of odorants in human axillary odour and laundry malodour: The importance of branched C7 chain analogues in malodours perceived by humans

Takeuchi¹,

Yabuki²,

Hasegawa³

2012

Flavour & Fragrance J

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In our daily lives we are confronted with various kinds of malodour problems. Detailed analysis at the molecular level of the malodorous constituents with gas chromatography–mass spectrometry and gas chromatography–olfactometry can be used to identify the key chemicals responsible for the malodours, and such information can provide novel starting points for the development of new deodorants. This paper describes two characteristic sources of malodour in daily life: axillary and laundry malodour. Detailed analytical studies identified specific major contributors to these malodours: 3‐hydroxy‐3‐methylhexanoic acid, 3‐mercapto‐3‐methylhexan‐1‐ol and 4‐methyl‐3‐hexenoic acid. Biochemical and microbiological studies then elucidated the mechanisms generating these odours and proved the involvement of microbes in odour formation. In this review, we discuss the importance of the branched C7 chain, which is common to all the major volatile substances identified in these studies and perceived by the human nose with an extraordinary sensitivity. Copyright © 2012 John Wiley & Sons, Ltd.

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Human sweat odour conjugates in human milk, colostrum and amniotic fluid

Cited by 9 publications

References 36 publications

Human neonates prefer colostrum to mature milk: Evidence for an olfactory bias toward the “initial milk”?

Human neonates prefer colostrum to mature milk: Evidence for an olfactory bias toward the “initial milk”?

The odour of human milk: Its chemical variability and detection by newborns

Review of odorants in human axillary odour and laundry malodour: The importance of branched C7 chain analogues in malodours perceived by humans

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