Human T-Cell Lymphotropic Virus in Patients Infected with HIV-1: Molecular Epidemiology and Risk Factors for Transmission in Piaui, Northeastern Brazil

Oliveira, Evaldo Hipólito de; Filho, Aldemir Branco de Oliveira; Souza, Lucinda Assunção Gustavo; Silva, Letiano V. da; Ishak, Marluísa de Oliveira Guimarães; Ishak, Ricardo; Vallinoto, Antônio Carlos Rosário

doi:10.2174/157016212803901374

Cited by 15 publications

(12 citation statements)

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“…Males represented the highest rate of analyzed samples, as well as the coinfected population (HIV/HTLV), corroborating previous reports 3,5,7 , although other studies have regarded females as most vulnerable to HTLV infection among PLWHA 4 .…”

Section: Coinfection Of Human T-cell Lymphotropic Virus (Htlv)supporting

confidence: 89%

“…The prevalence rate of 1.5% for HTLV/HIV coinfection reported in this study was lower than that in other studies conducted in different regions of the country 1,3,4,5,6 . However, the data were similar to those obtained in the state of Piauí (northeastern Brazil) 7 . This difference can be attributed to distinct regional endemicity, risk behaviors, and varied routes of HTLV exposure 4 .…”

Section: Coinfection Of Human T-cell Lymphotropic Virus (Htlv)supporting

confidence: 86%

“…In Brazil, HTLV/HIV coinfection rates vary by region, and studies showed a prevalence ranging from 2.25% to 21.11% 1,3,4,5,6,7 . There are no reports of coinfection rates in Pernambuco, and a study in blood donors 8 , showed a prevalence of 0.2%.…”

Section: Coinfection Of Human T-cell Lymphotropic Virus (Htlv)mentioning

confidence: 99%

“…Several studies have shown that HTLV infection rates are relatively high in the Hispanic and African-American populations 7 , suggesting that ethnicity may play a significant role in infection. In this study, three coinfected individuals were black and six pardo, consistent with previous research 4 , although several studies have shown coinfection in white/caucasian subjects as well 5,7 .…”

Section: Coinfection Of Human T-cell Lymphotropic Virus (Htlv)mentioning

confidence: 99%

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HTLV 1/2 Prevalence and risk factors in individuals with HIV/AIDS in Pernambuco, Brazil

Ribeiro

Gonçales

Morais

et al. 2019

Rev. Soc. Bras. Med. Trop.

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Introduction: Apart from masking the diagnosis of AIDS in patients with HIV/AIDS, human T-cell lymphotropic virus (HTLV), when present, also increases the risk of myelopathies and neurological disease in these patients. Methods: Disease prevalence was estimated by ELISA and confirmed by Western blot. Results: The coinfection rate was 1.5% (11/720); 10 of 11 patients had HTLV-1, and the remaining one had HTLV-2. The majority were male, over 40 years old, and of pardo color (ethnicity). Conclusions:There was no association between the risk factors examined and HTLV/HIV coinfection. This is the first study to report the occurrence of HTLV-2 in Pernambuco.

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Section: Coinfection Of Human T-cell Lymphotropic Virus (Htlv)supporting

confidence: 89%

Section: Coinfection Of Human T-cell Lymphotropic Virus (Htlv)supporting

confidence: 86%

Section: Coinfection Of Human T-cell Lymphotropic Virus (Htlv)mentioning

confidence: 99%

Section: Coinfection Of Human T-cell Lymphotropic Virus (Htlv)mentioning

confidence: 99%

See 2 more Smart Citations

HTLV 1/2 Prevalence and risk factors in individuals with HIV/AIDS in Pernambuco, Brazil

Ribeiro

Gonçales

Morais

et al. 2019

Rev. Soc. Bras. Med. Trop.

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“…[1][2][3] In Brazil, considered the country with the largest number of people infected by HTLVs, 4 HTLV-2 is considered endemic among indigenous populations of the Amazon region and among Indians of the south region, and is present in IDUs of urban areas and in patients with HIV/AIDS. [5][6][7][8][9][10] The HTLV-1/2 are low replicating viruses, thus have little genetic sequence variation. 11,12 However, the env structural gene and the long terminal repeat (LTR) region containing the viral promoter are the most variable regions, thus are useful for virus subtyping.…”

Section: Introductionmentioning

confidence: 99%

Human T Cell Lymphotropic Virus Type 2a Strains Among HIV Type 1-Coinfected Patients from Brazil Have Originated Mostly from Brazilian Amerindians

Magri

Brígido²,

Morimoto³

et al. 2013

AIDS Research and Human Retroviruses

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The human T cell lymphotropic virus type 2 (HTLV-2) is found mainly in Amerindians and in intravenous drug users (IDUs) from urban areas of the United States, Europe, and Latin America. Worldwide, HTLV-2a and HTLV-2b subtypes are the most prevalent. Phylogenetic analysis of HTLV-2 isolates from Brazil showed the HTLV-2a subtype, variant -2c, which spread from Indians to the general population and IDUs. The present study searched for the types of HTLV-2 that predominate among HIV-1-coinfected patients from southern and southeastern Brazil. Molecular characterization of the LTR, env, and tax regions of 38 isolates confirmed the HTLV-2c variant in 37 patients, and one HTLV-2b in a patient from Paraguay. Phylogenetic analysis of sequences showed different clades of HTLV-2 associated with risk factors and geographic region. These clades could represent different routes of virus transmission and/or little diverse evolutionary rates of virus. Taking into account the results obtained in the present study and the lack of the prototypic North American HTLV-2a strain and HTLV

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HTLV‐1 and ‐2 in a first‐time blood donor population in Northeastern Brazil: Prevalence, molecular characterization, and evidence of intrafamilial transmission

Ribeiro

Kozlowski

Matos

et al. 2018

Journal of Medical Virology

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Independent epidemiology for respective human T-cell lymphotropic virus (HTLV) types 1 and 2 is little known in blood donors in Brazil, where screening for HTLV-1/2 is mandatory at blood banks, but no testing to confirm/differentiate these viruses. Therefore, this study aims to assess the prevalence of HTLV-1 and -2 in a first-time blood donor population in Northeastern Brazil and to carry out molecular characterization of respective isolates. A cross-sectional study was conducted at the State Blood Bank in Piauí. Samples were screened for anti-HTLV-1/2 by enzyme immunoassay, and reactive samples were confirmed using a line immunoassay and polymerase chain reaction (PCR). Of 37 306 blood donors, 47 were anti-HTLV-1/2 reactive by enzyme immunoassay. After confirmed by line immunoassay, 22 were positive for HTLV-1 (0.59 per 1000; 95% CI: 0.38-0.87), 14 were positive for HTLV-2 (0.37 per 1000; 95% CI: 0.21-0.61), 1 was indeterminate, and the remaining donors were negative. The HTLV-1 infection was also confirmed by PCR in all anti-HTLV-1-positive samples, and sequencing classified these isolates as belonging to the Transcontinental (A) subgroup of the Cosmopolitan (1a) subtype. Of 14 anti-HTLV-2-positive samples, 11 were also PCR positive, which belonged to subtype a (HTLV-2a/c). In addition, 38 family members of 5 HTLV-1- and 3 HTLV-2-infected donors were analyzed. Familial transmission of HTLV-1 and -2 was evidenced in 3 families. In conclusion, in Northeastern Brazil, where HTLV-1 and -2 are endemic, counseling blood donor candidates and their families might play a key role in limiting the spread of these viruses.

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Human T-Cell Lymphotropic Virus in Patients Infected with HIV-1: Molecular Epidemiology and Risk Factors for Transmission in Piaui, Northeastern Brazil

Cited by 15 publications

References 0 publications

HTLV 1/2 Prevalence and risk factors in individuals with HIV/AIDS in Pernambuco, Brazil

HTLV 1/2 Prevalence and risk factors in individuals with HIV/AIDS in Pernambuco, Brazil

Human T Cell Lymphotropic Virus Type 2a Strains Among HIV Type 1-Coinfected Patients from Brazil Have Originated Mostly from Brazilian Amerindians

HTLV‐1 and ‐2 in a first‐time blood donor population in Northeastern Brazil: Prevalence, molecular characterization, and evidence of intrafamilial transmission

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