Human T-Cell Lymphotropic Virus Type I Infection in Barbados: Results of a 20-Year Follow-Up Study

Rabkin, Charles S.; Corbin, David E.; Felton, Sue; Barker, Harriet; Davison, Dorothy; Dearden, C J; Blattner, William A.; Evans, Alfred S.

doi:10.1097/00042560-199608150-00013

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…From the selected 50 articles, only 11 were finally included. 2,4,15,20–27 The paper by Gessain and Cassar 2 was repeatedly used because it includes many references on the epidemiology of HTLV-1 infection in Latin America and thus allowed a decrease in the number of references (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

2016

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Adult T-cell leukemia/lymphoma (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1) which is endemic in countries of Caribbean and Central and South America. We performed a systematic search and review to identify publications on ATL in these countries to verify if this disease was getting recognition in these regions as well as the characteristics of the observed cases. The median age of 49.4 years was lower than that referred to in Japan. According to our findings in most Brazilian states and in some other countries, ATL is not being recognized and should be strongly considered in the differential diagnosis of T-cell leukemias/lymphomas. Failure to identify these cases may be due to the unsystematic realization of serology for HTLV-1 and phenotypic identification of non-Hodgkin lymphomas that may result from lack of resources. Detection of ATL cases has been more feasible with cooperation from foreign research centers. A huge effort should be made to improve the surveillance system for ATL diagnosis in most of the South- and Central-American and Caribbean countries, and this attitude should be embraced by public organs to support health professionals in this important task.

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Section: Resultsmentioning

confidence: 99%

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

2016

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“…We measured cytokine levels in serum samples taken from a total of 76 subjects: 27 persons from a population-based random sample of asymptomatic adults from the United States (9), 11 human T-cell lymphotropic virus-1 negative subjects from a survey conducted in Barbados (10), and 38 blood donors at the Department of Transfusion Medicine, NIH (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

Reproducibility and Correlations of Multiplex Cytokine Levels in Asymptomatic Persons

Wong

Pfeiffer

Fears

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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136

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Rationale: Cytokines are humoral regulatory molecules that act together in immunologic pathways underlying pathogenesis. Grossly elevated blood levels characterize certain diseases; variations within physiologic ranges could also have significance. We therefore evaluated the performance characteristics of a multiplex cytokine immunoassay. Methods: We used a fluorescent bead-based (Luminex) immunoassay kit to simultaneously measure interleukin (IL) 1B, IL2, IL4, IL5, IL6, IL7, IL8, IL10, IL12p70, IL13, IFN;, granulocyte colony-stimulating factor, and tumor necrosis factor-A. We tested identical aliquots of serum from 38 asymptomatic individuals on three different days and matched sets of serum, heparinized plasma, and acid citrate dextrose plasma from an additional 38 healthy donors expected to have low cytokine concentrations. We applied multiple imputation to calculate unbiased reproducibility estimates for measurements below the limits of detection. Correlations among the cytokines were assessed by Spearman rank order coefficients and principal components analyses. Results: Of the 13 cytokines, 3 were undetectable (IL1B, IL2, IL5) in more than half of the serum samples. Coefficients of variation for replicate serum measurements ranged from 18% to 44%, with intraclass correlation coefficients ranging from 55% to 98%. Only IL4, IL6, and IL8 had statistically significant correlations (Spearman r, 0.42-0.94) between serum and acid citrate dextrose or heparin plasma levels. Conclusions: Interindividual differences outweigh substantial laboratory variation for these assays, yielding high intraclass correlation coefficients despite unimpressive coefficients of variation. Plasma measurements generally are not reflective of serum levels and hence are not interchangeable. With their small volume, low cost per test, and multiplex capacity, Luminex-based cytokine assays have potential utility for epidemiologic studies. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3450 -6)

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“…The seroepidemiology of HTLV-1 and HTLV-2 infection has been exten-sively studied in Central America and the Caribbean. The overall seroprevalence of infection from populationbased surveys ranges between 1% and 10% in most studies (Table 1) (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42). Age-dependent increase and female predominance in seroprevalence, as well as the presence of familial clustering, are similar to those observed in other endemic areas.…”

Section: Epidemiology Of Htlv Infection In Central America and The Caribbeanmentioning

confidence: 99%

HTLV in the Americas: challenges and perspectives

Carneiro-Proietti¹,

Catalan-Soares²,

Castro-Costa³

et al. 2006

Rev Panam Salud Publica

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The first description of the human T-lymphotropic virus type 1 (HTLV-1) was made in 1980, followed closely by the discovery of HTLV-2, in 1982. Since then, the main characteristics of these viruses, commonly referred to as HTLV-1/2, have been thoroughly studied. Central and South America and the Caribbean are areas of high prevalence of HTLV-1 and HTVL-2 and have clusters of infected people. The major modes of transmission have been through sexual contact, blood, and mother to child via breast-feeding. HTLV-1 is associated with adult T-cell leukemia/lymphoma (ATL), HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and HTLV-associated uveitis as well as infectious dermatitis of children. More clarification is needed in the possible role of HTLV in rheumatologic, psychiatric, and infectious diseases. Since cures for ATL and HAM/TSP are lacking and no vaccine is available to prevent HTLV-1 and HTLV-2 transmission, these illnesses impose enormous social and financial costs on infected individuals, their families, and health care systems. For this reason, public health interventions aimed at counseling and educating high-risk individuals and populations are of vital importance. In the Americas this is especially important in the areas of high prevalence.

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Human T-Cell Lymphotropic Virus Type I Infection in Barbados: Results of a 20-Year Follow-Up Study

Cited by 7 publications

References 16 publications

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

Reproducibility and Correlations of Multiplex Cytokine Levels in Asymptomatic Persons

HTLV in the Americas: challenges and perspectives

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