Human T-Lymphotropic virus (HTLV) type I in vivo integration in oral keratinocytes

Domínguez, Martha C.; González., Norma; Sánchez, Adolfo; Vallejo, Felipe García

doi:10.1590/s1517-83822011000100040

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…However, it remains to be determined whether those lymphocytes circulate for longer in saliva or are newly deposited in saliva and milk by leaking from microcirculation as has been reported previously (32)(33)(34)(35). There is some indirect evidence, both from our own study and previous work for HTLV-1 infection of oral mucosa by cellto-cell contact with circulating T cells, primarily through breast-feeding (32,(36)(37)(38).…”

Section: Discussionsupporting

confidence: 57%

“…Previous reports showed an association of the presence in HAM/TSP patients of free genomic HTLV-1 RNAs with an active production of sIgA in (31,32). Thus the differences recorded between HAM/TSP mothers and asymptomatic carriers in the mucosal associated response suggest that both immunological and cellular changes occur during progression to disease.…”

Section: Discussionmentioning

confidence: 85%

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Evaluación serológica y virológica de la infección del virus linfotrópico humano 1 en grupos familiares de Tumaco, Colombia

Domínguez

Salcedo²,

García

2015

biomedica

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Introduction:To date there has been no statistical evaluation of the profiles of immunoglobulin classes and viral replication as variables in the study of HTLV-1 infection and circulation among families in virusendemic areas of Colombia. Objective: To evaluate the correlation of several immunological and molecular characteristics with the transmission and circulation of HTLV-1 among families in the town of Tumaco. Materials and methods: Plasma levels of HTLV-1 specific immunoglobulin classes IgG, IgM and IgA1, as well as IgG and sIgA in oral fluids, were calculated for 32 members of 10 family groups from Tumaco in which the mother and at least one child were infected with the virus. Levels of the different immunoglobulin classes were correlated with viral RNA circulating in plasma or oral fluids and the proviral burden as detected by RT-PCR. Results: Significant differences were determined between mothers and carrier children for immunoglobulin levels (p=0.037) and proviral burden (p=0.002). The overall estimate of IgG in plasma and sIgA in oral fluids could be correlated with the circulation of free viral RNA in both fluids and high proviral burden, and associated with HAM/TSP mothers. The detection of anti-tax IgG in plasma revealed differences between HAM/TSP mothers and their offspring. Conclusion:The study of immunological and molecular variables permitted the analysis of HTLV-1 circulation among families of Tumaco. The strong correlation between levels of IgM specific for the virus and viral RNA circulating in fluids indirectly confirmed the transmission of HTLV-1 among families.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 85%

Evaluación serológica y virológica de la infección del virus linfotrópico humano 1 en grupos familiares de Tumaco, Colombia

Domínguez

Salcedo²,

García

2015

biomedica

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“…It worth to note that Gillet and Willems demonstrated absence of BLV DNA in breast cancer patient's DNA. HTLV-1 virus also had been found in the other type of cells in different nonhematological cancers [32]: (i) Endometrial adenocarcinoma in rabbits [33], (ii) Hepatocellular carcinoma (HCC) in patients with chronic HCV infection [34], (iii) Non-small cell lung cancer [35], (iv) Small cell lung cancer [36], (v) HTLV-1 is isolated from immortalized epithelial cells [31], and primary oral keratinocytes [37]. Also, it was shown that HTLV-1 increases risk of bronchioloalveolar carcinoma [38].…”

Section: Viral Proteins As Factors Affecting Specific Cancer Pathwaysmentioning

confidence: 99%

HTLV-1 can be involved in acceleration of different nonhematological cancers

Vl¹,

CHEN²,

If³

2019

J Cancer Res Ther.

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In the past two decades it has been found that viral proteins might contribute to activation of numerous pathways involved in different types of cancer. Human T-lymphotropic virus 1 (HTLV-1), well known as a cause of T-cell leukemia, was found in patients having different types of cancers. Initiation and development of cancers is usually a multi-year multistep process that starts with initiation of the first somatic mutation and the then the next set of steps with the occurrence of an increasing number of somatic mutations with specific times for each one. Here we suggest a hypothesis: If HTLV-1 virus can infect the nonhematological cell, its viral proteins can work as the agents activating the general cancer-related pathways. This way Tax HTLV-1 protein (and/or other viral proteins) can serve in the similar way as the somatic mutation of specified genes and the presence of Tax can affect the functionality of several pathways that are not yet activated by the timeline of the stages of a "normal" cancer development. For example, the pathways PI3K, p53, TGF-β can be correspondingly be activated and inhibited by Tax before their functional change would appear by the timeline of a "normal" cancer development. The HTLV-1 infection-related KEGG pathway was found when the sets of the most frequently mutated genes for several cancers were analyzed by the DAVID program (that selects the most probable pathways for a set of selected genes). These findings support the hypotheses that HTLV-1 infection can be a common factor in the development of very different cancers, thus warranting further exploration.

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A narrative review: exploring viral-induced malignancies through the lens of dysregulated cellular metabolism and glucose transporters

Shahpar,

Sofiani,

Nezhad

et al. 2024

BMC Cancer

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Introduction In this narrative review, we unravel the complex interplay between oncogenic viruses, cellular metabolism, and glucose transporter (GLUT) dysregulation in viral-induced malignancies. Methods By explaining the diverse mechanisms through which seven major oncoviruses manipulate metabolic pathways and GLUT expression, particularly GLUT1, we provide novel insights into the critical role of metabolic reprogramming in viral replication and oncogenesis. Results Our exploration of the molecular pathways targeted by viral oncoproteins reveals a similarity between the metabolic alterations induced by viral infections and those observed in neoplastic transformation. A key finding of our review is the overexpression of GLUTs, particularly GLUT1, as a hallmark of both viral infections and many cancers. Conclusions By elucidating the complex interplay between viral oncoproteins, oncogene activation, tumor suppressor gene loss, and GLUT overexpression, we highlight the potential of GLUTs as novel targets for diagnosis, prognosis, and therapy of viral-induced malignancies.

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Human T-Lymphotropic virus (HTLV) type I in vivo integration in oral keratinocytes

Abstract: Although the infection of HTLV-1 to cell components of the mouth have been previously reported, there was not until this report, a detailed study to show the characteristics of such infection.

Cited by 3 publications

References 39 publications

Evaluación serológica y virológica de la infección del virus linfotrópico humano 1 en grupos familiares de Tumaco, Colombia

Evaluación serológica y virológica de la infección del virus linfotrópico humano 1 en grupos familiares de Tumaco, Colombia

HTLV-1 can be involved in acceleration of different nonhematological cancers

A narrative review: exploring viral-induced malignancies through the lens of dysregulated cellular metabolism and glucose transporters

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