Human T Lymphotropic Virus-I (HTLV-I), the Causative Agent of Acute T-Cell Leukaemia/Lymphoma, Is Absent among Blood Donors in Aseer Region, Saudi Arabia

Alshehri, Ali

doi:10.4197/sci.26-1.3

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…The low prevalence among donors in Saudi Arabia has been shown repeatedly in many studies. Table summarises the studies conducted in Saudi Arabia since 1991 (Bernvil et al ., ; Arif & Ramia, ; Fathalla et al ., ; Al Jaouni, ; Taha et al ., ; Balkhy et al ., ; El‐Hazmi, ; Ul‐Hassan et al ., ; Fawaz et al ., ; Ghazi, ; Alshehri, ). Interestingly, significant numbers of donors positive for HTLV 1 and HTLV 2 by confirmatory testing are limited to reports from the Eastern region of Saudi Arabia (Fathalla et al ., ; Taha et al ., ; Ul‐Hassan et al ., ; Fawaz et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Testing for HTLV 1 and HTLV 2 among blood donors in Western Saudi Arabia: prevalence and cost considerations

Hindawi

Badawi

Fouda

et al. 2017

Transfusion Medicine

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Section: Discussionmentioning

confidence: 99%

Testing for HTLV 1 and HTLV 2 among blood donors in Western Saudi Arabia: prevalence and cost considerations

Hindawi

Badawi

Fouda

et al. 2017

Transfusion Medicine

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“…Likewise, Ibrahim et al demonstrated a rate of 0.26% (39/15239) HTLV-1/2 seropositivity among samples collected in Iraqi blood banks using enzyme-linked and chemiluminescent immunoassays [104]. No or meager seroprevalence rates of HTLV-1 infection were reported in blood donors from Jordan [105], Kuwait [106], Lebanon [107,108], Pakistan [111], and different parts of Saudi Arabia [109,[114][115][116][117][118]120,122,124,125]. In Lebanon, no HTLV-1 positive cases were found initially among blood donors and even in high-risk groups such as PWID, hemophilia patients, or those with malignancy who received multiply blood transfusions [107].…”

Section: Htlv-1 Infection In Asian Countries Of Emromentioning

confidence: 99%

Updates on the Epidemiology of the Human T-Cell Leukemia Virus Type 1 Infection in the Countries of the Eastern Mediterranean Regional Office of the World Health Organization with Special Emphasis on the Situation in Iran

Hedayati-Moghaddam

Esfehani

Hajj

et al. 2022

Viruses

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Background: The epidemiology and prevalence of the Human T-cell leukemia virus type-1 (HTLV-1) infection represent a recommended priority by global health agencies. An in-depth revision to update the status of this infection in countries including those of the Eastern Mediterranean Regional Office (EMRO) of the World Health Organization is hence required. Methods: Ninety-seven studies evaluating the HTLV-1 infection in low- and high-risk populations in EMRO countries were retrieved from the international electronic databases and were used to assess the epidemiological status of the infection in these countries. Results: Most epidemiologic reports were published from Iran, with more than 50% of Iranian prisoners and around 4% of healthy individuals reported to have the infection. In Egypt, a considerable prevalence of the virus spans around 1.11% of blood donors. Foci of HTLV-1 infection are also present in some countries and require a careful epidemiological evaluation. In the other EMRO countries, a lower prevalence that does not exceed 1% was reported. Conclusion: The epidemiology and prevalence of HTLV-1 in the EMRO countries require a tight revision and update. Published studies reveal a scarce distribution of the virus in the African countries of EMRO, while a lower prevalence is denoted in the Asian countries of EMRO, except in Iran, where the prevalence is high.

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Changes in Serum Protein and Enzyme Levels in Human T Lymphotropic Virus-1-Infected Patient

Almaiman

2020

J Coll Physicians Surg Pak

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This study aims to evaluate the changes in serum protein levels in a patient with confirmed human T lymphotropic virus type-1 (HTLV-1) infection. Screening and confirmation tests were performed for HTLV-1, along with an assessment of overall albumin, alpha 1 and 2, and gamma and beta globulin levels, using SAS-3 protein electrophoretic analysis. HTLV-1 positivity was confirmed with enzyme-linked immunosorbent assay (ELISA) and nucleic acid amplification testing (NAT). The biochemical tests or protein levels did not exhibit any changes in HTLV-1 infection, indicating that HTLV-1 results in a rare silent infection that does not result in changes in protein levels at the early stages. To aid early detection of the virus and initiate treatment, a comprehensive investigation at the protein and gene levels should be performed.

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Human T Lymphotropic Virus-I (HTLV-I), the Causative Agent of Acute T-Cell Leukaemia/Lymphoma, Is Absent among Blood Donors in Aseer Region, Saudi Arabia

Cited by 3 publications

References 41 publications

Testing for HTLV 1 and HTLV 2 among blood donors in Western Saudi Arabia: prevalence and cost considerations

Testing for HTLV 1 and HTLV 2 among blood donors in Western Saudi Arabia: prevalence and cost considerations

Updates on the Epidemiology of the Human T-Cell Leukemia Virus Type 1 Infection in the Countries of the Eastern Mediterranean Regional Office of the World Health Organization with Special Emphasis on the Situation in Iran

Changes in Serum Protein and Enzyme Levels in Human T Lymphotropic Virus-1-Infected Patient

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