Human T‐lymphotropic virus type I among blood donors from Guadeloupe: donation, demographic, and biologic characteristics

Raffi, François; Foucher, Corinne; Rabier, M.; Gawronski, I.; Taverne, D.; Chancerel, Bruno; Casman, O.; Strobel, M

doi:10.1046/j.1537-2995.1999.39060639.x

Cited by 20 publications

(13 citation statements)

References 18 publications

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“…25,26 Taken together, a birth cohort effect should be taken into account in the age-dependent rise in HTLV-I prevalence. 27 This effect observed in this study for HTLV-I suggests that improved screening strategies might be applied to 35 and above years old in Mashhad. On the other hand, a population-based study in French Guiana reported an HTLV-I infection in subjects with all age groups suggesting that other factors might be involved in virus transmission.…”

Section: Discussionmentioning

confidence: 58%

High prevalence of HTLV-I infection in Mashhad, Northeast Iran: A population-based seroepidemiology survey

Rafatpanah

Hedayati-Moghaddam

Fathimoghadam

et al. 2011

Journal of Clinical Virology

127

118

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Section: Discussionmentioning

confidence: 58%

High prevalence of HTLV-I infection in Mashhad, Northeast Iran: A population-based seroepidemiology survey

Rafatpanah

Hedayati-Moghaddam

Fathimoghadam

et al. 2011

Journal of Clinical Virology

127

118

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“…The sequences in the LTR phylogenetic tree are reported elsewhere (12,13,23,24,46,49,50). donated blood, the prevalences being 0.33% in Guadeloupe and 0.4% in Martinique in 1999 (5,37).…”

Section: Discussionmentioning

confidence: 96%

High Seroprevalence of Human T-Cell Lymphotropic Virus Type 1 in Blood Donors in Guyana and Molecular and Phylogenetic Analysis of New Strains in the Guyana Shelf (Guyana, Suriname, and French Guiana)

Pouliquen

Hardy²,

Lee

et al. 2004

J Clin Microbiol

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The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 in blood donors in Guyana has never been estimated. We evaluated the prevalence of these viruses in blood donors by enzyme-linked immunosorbent assay and Western blotting and showed a prevalence of HTLV-1 of 1.3%; no HTLV-2 was detected. Female donors had a much higher HTLV-1 seroprevalence (3.6%) than male donors (0.7%). HTLV-1-seropositive donors tended to be slightly older than the average age for the total pool of donors. We also investigated the phylogenetic and molecular characteristics of HTLV-1 strains in Guyana and compared them with those identified in Suriname and French Guiana. Analysis of portions of the env and long terminal repeat nucleotide sequences showed that all the strains in Guyana and Suriname, like those in French Guiana, belonged to the transcontinental group of cosmopolitan subtype A. The similarities were greater between strains from Suriname and Guyana than between strains from Suriname and Guyana and those from French Guiana. Nevertheless, our results confirm that the HTLV-1 strains in all three countries have a common African origin.

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“…in blood donors has been found in Jamaica (2.1%) (12). Such comparisons must be made cautiously because screening tests, specificity in marker levels, and medical selection of blood donors can vary from one study to another, but we have attempted to accomplish standard screening tests.…”

Section: Discussionmentioning

confidence: 99%

“…This pattern is also well documented in previous studies, which could be explained by a cohort effect (14) and by cumulative effect of infections occurring over the lifetime of individuals, such as by heterosexual transmission. The age-dependent rise in HTLV-1 prevalence could also be explained by a birth cohort effect (12).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Human T-Lymphotropic Virus Type 1 among Blood Donors from Mashhad, Iran

Abbaszadegan¹,

Gholamin²,

Tabatabaee

et al. 2003

J Clin Microbiol

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The city of Mashhad is the capital of Khorasan, the northeastern province of Iran, which has been recognized as an area where human T-lymphotropic virus type 1 (HTLV-1) infection is endemic. All serum samples from blood donors are routinely screened for HTLV-1 by using enzyme-linked immunosorbent assay (ELISA). In the present study, 28,926 donors (81.86% male and 18.14% female) with a mean age of 32 years (range, 18 to 65 years) were screened in a 6 months period (July to December 1999). Of these donors in the primary screening, 228 (0.78%) tested positive by ELISA. The positive samples were confirmed by Western blot (WB) analysis. The WB results indicated that, of 228 positive ELISA specimens, 91.2% (208 specimens) were HTLV-1, 4.82% (11 specimens) were HTLV, 3.5% (8 specimens) were indeterminate, and 0.44% (1 specimen) was not confirmed. HTLV refers to samples in which the complete viral antigen banding patterns on WB strips were not present. In order to further evaluate the detection methodologies used, the HTLV-1-seropositive samples, the indeterminant samples, and/or HTLV samples were examined and confirmed by PCR. The HTLV samples were determined to be HTLV-1, the remaining samples were indeterminant, and the negative sample could not be confirmed for HTLV-1 by PCR. The prevalence of HTLV-1 infection in our study was 0.77% among blood bank donors, which reconfirms the city of Mashhad as an area where the virus is endemic compared to other regions in the world. The incidence was correlated with increasing age, and it was higher in females than in males.

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Human T‐lymphotropic virus type I among blood donors from Guadeloupe: donation, demographic, and biologic characteristics

Abstract: New donor status, advancing age, female sex, and positivity for hepatitis B virus core antibodies were the major factors associated with HTLV-I infection in Guadeloupe.

Cited by 20 publications

References 18 publications

High prevalence of HTLV-I infection in Mashhad, Northeast Iran: A population-based seroepidemiology survey

High prevalence of HTLV-I infection in Mashhad, Northeast Iran: A population-based seroepidemiology survey

High Seroprevalence of Human T-Cell Lymphotropic Virus Type 1 in Blood Donors in Guyana and Molecular and Phylogenetic Analysis of New Strains in the Guyana Shelf (Guyana, Suriname, and French Guiana)

Prevalence of Human T-Lymphotropic Virus Type 1 among Blood Donors from Mashhad, Iran

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