Human talar ontogeny: Insights from morphological and trabecular changes during postnatal growth

Figus, Carla; Stephens, Nicholas B.; Sorrentino, Rita; Bortolini, Eugenio; Arrighi, Simona; Lugli, Federico; Marciani, Giulia; Oxilia, Gregorio; Romandini, Matteo; Silvestrini, Sara; Baruffaldi, Fabio; Belcastro, Maria Giovanna; Bernardini, Federico; Erjavec, Igor; Festa, Anna; Hajdu, Tamás; László, Orsolya; Novak, Mario; Pap, Ildikó; Szeniczey, Tamás; Tuniz, Claudio; Ryan, Timothy M.; Benazzi, Stefano

doi:10.1002/ajpa.24596

Cited by 8 publications

(16 citation statements)

References 126 publications

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“…These adult trajectories have been strongly associated with the transmission of forces during walking (Pal & Routal, 1998;Takechi et al, 1982), and therefore their appearance may be attributed to the development of the bipedal gait in the juvenile talus. This is in agreement with the micro-computed tomography findings of Figus, Stephens, Sorrentino, Bortolini, Arrighi, Higgins, et al (2022) and Figus, Stephens, Sorrentino, Bortolini, Arrighi, Lugli, et al (2022) in the juvenile talus.…”

Section: Ta B L Esupporting

confidence: 92%

“…This is consistent with the description of curved trabecular plates in the sagittal plane within the head of the adult talus (Athavale et al, 2008;Ebraheim et al, 1999;Krause et al, 2013;Pal & Routal, 1998;Saers et al, 2018;Sinha, 1985;Takechi et al, 1982). Additionally, high BV/TV values have been observed at the articular surface of the navicular in the adult talus (Tsegai et al, 2017) and the juvenile talus (Figus, Stephens, Sorrentino, Bortolini, Arrighi, Higgins, et al, 2022, Figus, Stephens, Sorrentino, Bortolini, Arrighi, Lugli, et al, 2022.…”

Section: Ta B L Esupporting

confidence: 88%

“…After loading, bone volume fraction and trabecular number decreased while trabecular thickness, separation, and anisotropy increased, suggesting the acquisition of the bipedal gait influences the internal structure of the talus. Figus, Stephens, Sorrentino, Bortolini, Arrighi, Lugli, et al ( 2022 ) continued this work and demonstrated that anisotropy and bone volume fraction become more heterogeneous after loading. This current work aims to add to the growing understanding of the developing juvenile talus by radiographically identifying ontogenetic phases and developmental patterns in the talus from 28 weeks intrauterine to 20 years of age.…”

Section: Introductionmentioning

confidence: 77%

“…Therefore, the body of the talus presents an area of the developing skeleton that may be sensitive to biomechanical changes occurring during ontogeny when an infant learns to sit upright, crawl, and walk. The results of Figus, Stephens, Sorrentino, Bortolini, Arrighi, Higgins, et al (2022) and Figus, Stephens, Sorrentino, Bortolini, Arrighi, Lugli, et al, 2022) indicate that the talus is influenced by these biomechanical changes. This work seeks to confirm this radiographically over a wider age range.…”

mentioning

confidence: 93%

“…The trabecular development of the juvenile human talus, however, has received limited investigation except for Figus, Stephens, Sorrentino, Bortolini, Arrighi, Higgins, et al ( 2022 ) and Figus, Stephens, Sorrentino, Bortolini, Arrighi, Lugli, et al ( 2022 ). Figus, Stephens, Sorrentino, Bortolini, Arrighi, Higgins, et al ( 2022 ) examined the talus from 36 weeks intrauterine to 2 postnatal years, while Figus, Stephens, Sorrentino, Bortolini, Arrighi, Lugli, et al ( 2022 ) investigated the talus from 8 postnatal weeks to 10 years of age through geometric morphometric and whole‐bone trabecular analysis. In a Late Roman to 20th century sample, Figus, Stephens, Sorrentino, Bortolini, Arrighi, Higgins, et al ( 2022 ) compared pre‐loading specimens ( n = 11, <6 postnatal months) with post‐loading specimens ( n = 17, 6–24 postnatal months).…”

Section: Introductionmentioning

confidence: 99%

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The developing juvenile talus: Radiographic identification of distinct ontogenetic phases and structural trajectories

2023

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Trabecular bone architecture in the developing skeleton is a widely researched area of bone biomechanics; however, despite its significance in weight‐bearing locomotion, the developing talus has received limited examination. This study investigates the talus with the purpose of identifying ontogenetic phases and developmental patterns that contribute to the growing understanding of the developing juvenile skeleton. Colour gradient mapping and radiographic absorptiometry were utilised to investigate 62 human tali from 38 individuals, ranging in age‐at‐death from 28 weeks intrauterine to 20 years of age. The perinatal talus exhibited a rudimentary pattern comparable to the structural organisation observed within the late adolescent talus. This early internal organisation is hypothesised to be related to the vascular pattern of the talus. After 2 years of age, the talus demonstrated refinement, where radiographic trajectories progressively developed into patterns consistent with adult trabecular organisation, which are linked to the forces associated with the bipedal gait, suggesting a strong influence of biomechanical forces on the development of the talus.

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Section: Ta B L Esupporting

confidence: 92%

Section: Ta B L Esupporting

confidence: 88%

Section: Introductionmentioning

confidence: 77%

mentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The developing juvenile talus: Radiographic identification of distinct ontogenetic phases and structural trajectories

2023

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Trabecular bone variation in the gorilla calcaneus

Harper,

Patel

2024

American Journal of Biological Anthropology

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ObjectivesCalcaneal external shape differs among nonhuman primates relative to locomotion. Such relationships between whole‐bone calcaneal trabecular structure and locomotion, however, have yet to be studied. Here we analyze calcaneal trabecular architecture in Gorilla gorilla gorilla, Gorilla beringei beringei, and G. b. graueri to investigate general trends and fine‐grained differences among gorilla taxa relative to locomotion.Materials and methodsCalcanei were micro‐CT scanned. A three‐dimensional geometric morphometric sliding semilandmark analysis was carried out and the final landmark configurations used to position 156 volumes of interest. Trabecular thickness (Tb.Th), trabecular spacing (Tb.Sp), and bone volume fraction (BV/TV) were calculated using the BoneJ plugin for ImageJ and MATLAB. Non‐parametric MANOVAs were run to test for significant differences among taxa in parameter raw values and z‐scores. Parameter distributions were visualized using color maps and summarized using principal components analysis.ResultsThere are no significant differences in raw BV/TV or Tb.Th among gorillas, however G. b. beringei significantly differs in z‐scores for both parameters (p = <0.0271). All three taxa exhibit relatively lower BV/TV and Tb.Th in the posterior half of the calcaneus. This gradation is exacerbated in G. b. beringei. G. b. graueri significantly differs from other taxa in Tb.Sp z‐scores (p < 0.001) indicating a different spacing distribution.DiscussionRelatively higher Tb.Th and BV/TV in the anterior calcaneus among gorillas likely reflects higher forces associated with body mass (transmitted through the subtalar joint) relative to forces transferred through the posterior calcaneus. The different Tb.Sp pattern in G. b. graueri may reflect proposed differences in foot positioning during locomotion.

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Trabecular Bone Ontogeny of the Human Distal Tibia

Reid,

Davies,

Cunningham

2024

American Journal of Biological Anthropology

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ObjectivesThere is an increasing understanding of how trabecular bone adapts to biomechanical changes during ontogeny. However, limited research exists regarding the distal tibia, which is important in weight‐bearing locomotion as part of the ankle joint. This study aims to document the ontogenetic trabecular patterns of the distal tibia, in addition to changes in its structural heterogeneity.Materials and MethodsThirty‐eight distal tibiae, ranging in age from 28 intrauterine weeks to 8 postnatal years, from the Scheuer juvenile skeletal collection were examined. Trabecular bone was analyzed using a quantitative volume of interest approach and qualitative whole bone mapping following microcomputed tomography.ResultsFetal and perinatal tibia lack mature organization and are associated with high bone volume fraction. During the first year of life, there is a decrease in bone volume fraction and an indication of early re‐organization of trabecular struts in the distal tibia. After one year of age, the distal tibia exhibits increased trabecular structural heterogeneity.DiscussionThe trabecular architecture of the fetal and perinatal distal tibia lacks mature organization and instead reflects ossification patterns. At these stages, there is a rapid accumulation of bone mass associated with gestational overproduction, hypothesized to be in preparation for subsequent postnatal changes. During the first year of life there is a decrease in volume fraction, associated with constructive regression. It is postulated this is related to changing biomechanical forces associated with the bipedal gait, in addition to growth demands. After one year of age, the distal tibia exhibits structural heterogeneity with trabecular adaption to accommodate specific bipedal stresses.

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Human talar ontogeny: Insights from morphological and trabecular changes during postnatal growth

Cited by 8 publications

References 126 publications

The developing juvenile talus: Radiographic identification of distinct ontogenetic phases and structural trajectories

The developing juvenile talus: Radiographic identification of distinct ontogenetic phases and structural trajectories

Trabecular bone variation in the gorilla calcaneus

Trabecular Bone Ontogeny of the Human Distal Tibia

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