Human temporal bone feedings in acquire hypothyroidism

Abstract

Histological studies of the auditory organ in patients with acquired hypothyroidism are scarce. Thus the aim of the present study was to examine the temporal bones and the brain in subjects with hypothyroidism. Four temporal bones and two brains from clinically and biochemically hypothyroid subjects were removed and evaluated by light microscopy determine to the morphological changes and deposition of neutral and acid glycosaminoglycans. An audiogram from one of the patients showed a sensorineural hearing loss, which could be ascribed to occupational noise exposure. The study revealed histological changes compatible with age and infectious disease. No accumulation of neutral or acid glycosaminoglycans could be demonstrated in the temporal bones, or in the brains.

Effects of acute thyroxin depletion on hearing in humans

“…Parving et al 10 showed that levothyroxine administration does not improve hearing sensitivity in patients with myxedema. Moreover, histologic examination of temporal bones in these patients failed to show accumulation of glycoaminoglycans 10,11 …”

“…The literature contains many references describing an association between thyroid disorders and auditory system dysfunction 2–18 . Yet a direct action of thyroxin on the peripheral hearing organ in humans has never been described.…”

Audiological Evaluation in Goitrous Hypotyhroidism

“…Thus it is widely accepted that improvement in hearing following levothyroxine therapy is attributed to improved general condition of the patient resulting in improved co-operation in psycho-acoustic testing, the so called functional improvement in central deafness [4,12,14]. The histological examination of temporal bones in these patients has also failed to show accumulations of glycoaminoglycans [4,21,22]. It would however be imperative to note that con-ductive hearing loss in hypothyroidism is secondary to Eustachian tube mucosal oedema [23].…”

Electrophysiological Tests of the Hearing Organ in Hashimoto's Disease

“…In the last few years many authors have paid attention to hearing organ disturbances resulting from the presence of autoimmunological processes 12 . Among different immunoglobins present in this disease, in clinical practice antithyroperoxidase (ATPO) antibodies are detected.…”