Human Tip60 (NuA4) Complex and Cancer

Yamada, Hiroshi

doi:10.5772/28295

Cited by 1 publication

(2 citation statements)

References 115 publications

(131 reference statements)

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“…Therefore, it is possible that in the absence of Myc or the Tip60 complex, which appears to contribute to Myc target gene expression, no NB tumors can form. Since both Myc and Tip60 complex components are frequently mutated in mammalian cancers (reviewed in Dang, 2012;Yamada, 2012), it will be of interest to investigate the responsible target genes further.…”

Section: Myc and The Tip60 Complex Regulate Mitotic Spindle Morphologmentioning

confidence: 99%

“…Several transcription factors and upstream regulators have been shown to functionally interact with the Tip60 complex, including c-Myc, p53, E2Fs, and H3K4-methyltransferases (reviewed in Yamada, 2012). c-Myc is a potential interactor that is likely to determine target gene specificity of the Tip60 complex in pluripotent stem cells by recruiting the complex to chromatin (Frank et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in Drosophila

et al. 2018

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Stem cells establish cortical polarity and divide asymmetrically to simultaneously maintain themselves and generate differentiating offspring cells. Several chromatin modifiers have been identified as stemness factors in mammalian pluripotent stem cells, but whether these factors control stem cell polarity and asymmetric division has not been investigated so far. We addressed this question in neural stem cells called neuroblasts. We identified the Tip60 chromatin remodeling complex and its interaction partner Myc as regulators of genes required for neuroblast maintenance. Knockdown of Tip60 complex members results in loss of cortical polarity, symmetric neuroblast division, and premature differentiation through nuclear entry of the transcription factor Prospero. We found that aPKC is the key target gene of Myc and the Tip60 complex subunit Domino in regulating neuroblast polarity. Our transcriptome analysis further showed that Domino regulates the expression of mitotic spindle genes previously identified as direct Myc targets. Our findings reveal an evolutionarily conserved functional link between Myc, the Tip60 complex, and the molecular network controlling cell polarity and asymmetric cell division.

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Section: Myc and The Tip60 Complex Regulate Mitotic Spindle Morphologmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%