Human Tissue Kallikreins in Polymorphous Adenocarcinoma: A Polymerase Chain Reaction and Immunohistochemical Study

Cox, John C.; Khan, Zia A.; Jackson-Boeters, Linda; Armstrong, J.E.; Darling, Mark

doi:10.1007/s12105-020-01196-2

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…KLK members regulate diverse biological processes and have a crucial involvement in cell proliferation, signaling, migration, and invasion [3]. KLKs are mainly immunolocalized in the nucleus and/or cytoplasm of carcinoma cells [4], and KLKs modulate the progression and metastasis of various carcinomas positively or negatively via a wide range of molecular mechanisms [5]. Emerging evidence suggests the importance of KLKs in breast cancers.…”

Section: Introductionmentioning

confidence: 99%

Kallikrein-Related Peptidase 12 (KLK12) in Breast Cancer as a Favorable Prognostic Marker

Sato

Takagi

Yoshimura

et al. 2023

IJMS

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Kallikrein-related peptides (KLKs) form an evolutionally conserved subgroup of secreted serine proteases that consists of 15 members (KLK1-15). Previous studies have shown that KLKs regulate diverse biological processes, but the clinical significance of KLKs remains largely unclear in human breast cancers. We examined the expression profile of 15 KLK genes in breast carcinomas using microarray data. Next, we immunolocalized KLK12 in 140 breast carcinomas and evaluated its clinical significance. Subsequently, we examined the effects of KLK12 on proliferation and migration in breast cancer cell lines. From microarray analyses, it turned out that KLK12 was the most strongly associated with low-grade malignancy in breast carcinomas among the 15 KLK members. Immunohistochemical KLK12 status was positively associated with ER and PR status, while it was inversely associated with stage, pathological T factor, lymph node metastasis, and distant metastasis. Prognostic analyses demonstrated that KLK12 was a favorable prognostic factor for both disease-free and breast cancer-specific survival of the patients. Furthermore, the knockdown of KLK12 significantly increased cell proliferation activity and cell migration of breast cancer cells. These results suggest that KLK12 has antitumorigenic effects associated with proliferation and migration and immunohistochemical KLK12 status as a potent favorable prognostic factor in breast carcinoma patients.

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Section: Introductionmentioning

confidence: 99%

Kallikrein-Related Peptidase 12 (KLK12) in Breast Cancer as a Favorable Prognostic Marker

Sato

Takagi

Yoshimura

et al. 2023

IJMS

View full text Add to dashboard Cite

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Salivary duct carcinoma of parotid gland with femur metastasis: Case report and literature review

Pantelas,

Salloumis,

Myrto

et al. 2024

Balkan J Dent Med

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Histologically similar to both in situ and invasive ductal carcinoma of the breast, salivary duct carcinoma (SDC) is an uncommon and excessively aggressive subtype of primary salivary gland carcinoma. The salivary gland most frequently involved in cancer cases is the parotid. With an estimated frequency of 1 in 1,000,000 individuals, SDC is an incredibly rare cancer that is more common in men. Due of its early metastasis to distant areas and regional lymph nodes, it is frequently identified at an advanced stage. Case report: We present a case of SDC of the parotid gland with femur bone metastasis as well as a detailed literature review for SDC. According to the existing literature, this is the first reported case of salivary duct carcinoma of the parotid gland with femur metastasis. Currently the patient remains stable with no signs or symptoms of recurrence. Conclusions: It is crucial to note the possibility of femur metastasis from salivary duct carcinoma of the parotid gland for the most appropriate treatment plan determination, and a more comprehensive understanding of the disease's progression.

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Human Tissue Kallikreins in Polymorphous Adenocarcinoma: A Polymerase Chain Reaction and Immunohistochemical Study

Cited by 2 publications

References 18 publications

Kallikrein-Related Peptidase 12 (KLK12) in Breast Cancer as a Favorable Prognostic Marker

Kallikrein-Related Peptidase 12 (KLK12) in Breast Cancer as a Favorable Prognostic Marker

Salivary duct carcinoma of parotid gland with femur metastasis: Case report and literature review

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