Human-to-dog Transmission of SARS-CoV-2 Lota Variant: Should COVID-19 Patients Avoid Close Contact with their Pets During Illness?

Rivero, Ricardo; Garay, Evelin; Botero, Yesica; Serrano-Coll, Héctor; Gastelbondo, Bertha; Muñoz, Marina; Ballesteros, Nathalia; Castañeda, Sergio; Patiño, Luz Helena; Ramírez, Juan David; Calderón, Alfonso; Guzmán, Camilo; Martínez-Bravo, Caty; Alemán, Ader; Arrieta, Germán; Máttar, Salim

doi:10.21203/rs.3.rs-821033/v1

Cited by 5 publications

(4 citation statements)

References 37 publications

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“…RT-qPCR and successful genome sequencing detected SARS-CoV-2 in a cat (EPI_ISL2339859.2) and a dog (EPI_ISL8422346) in two different cities for a total active infection rate of 0.69% in the department of Córdoba, Colombia ( Table IV ). 8 …”

Section: Resultsmentioning

confidence: 99%

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First report and genome sequencing of SARS-CoV-2 in a cat (Felis catus) in Colombia

Botero

Ramírez

Serrano-Coll

et al. 2022

Mem. Inst. Oswaldo Cruz

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BACKGROUND Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus of zoonotic origin that can bind to ACE2 receptors on the cells of many wild and domestic mammals. Studies have shown that the virus can circulate among animals mutate, lead to animal-to-human zoonotic jump, and further onward spread between humans. Infection in pets is unusual, and there are few human-to-pet transmission reports worldwide. OBJECTIVE To describe the SARS-CoV-2 infection in a domestic animal in Córdoba, Colombian Caribbean region. METHODS A cross-sectional molecular surveillance study was carried out, oral and rectal swabs were taken from cats and dogs living with people diagnosed with coronavirus disease 2019 (COVID-19). RESULTS SARS-CoV-2 was found in a cat living with a person with COVID-19. Genome sequencing showed that the B.1.111 lineage caused the infection in the cat. The owner’s sample could not be sequenced. The lineage is predominant in Colombia, and this variant is characterised by the presence of the D614D and Q57H mutation. CONCLUSION The present work is the first report of an infected cat with SARS-CoV-2 with whole-genome sequencing in Colombia. It highlights the importance of detecting SARS-CoV-2 mutations that could promote the transmissibility of this new coronavirus. There is still a significant information gap on human-to-cat-to-human infection; we encourage self-isolation measures between COVID-19 patients and companion animals. The findings of this study give a preliminary view of the current panorama of SARS-CoV-2 infection in animals in Colombia.

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Section: Resultsmentioning

confidence: 99%

“…3 , 4 , 5 To date, less than 400 cases describing animals infected with SARS-CoV-2 have been reported, 3 a few with genomic analyses, 3 , 6 , 7 and only one described in Colombia, a country located in the tropics that has been heavily hit by the pandemic. 8 …”

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confidence: 99%

First report and genome sequencing of SARS-CoV-2 in a cat (Felis catus) in Colombia

Botero

Ramírez

Serrano-Coll

et al. 2022

Mem. Inst. Oswaldo Cruz

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“…After removing the duplicates, 6636 studies remained for title and abstract screening. In total, 47 studies were eligible for screening the full text, of which 6593 did not meet the inclusion criteria for the following reasons: short communication, 5 brief report, 3 review studies, 74 systematic reviews 8 and no relevant article (6511). Thus, 39 studies met the inclusion criteria and were included in this review.…”

Section: Resultsmentioning

confidence: 99%

An overview of SARS‐CoV2 natural infections in companion animals: A systematic review of the current evidence

Heydarifard,

Chegeni,

Heydarifard

et al. 2024

Reviews in Medical Virology

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This systematic review provides a comprehensive overview of natural SARS‐CoV‐2 infections in companion animals. The findings show that these infections are relatively rare. Among the examined dogs, only 1.32% tested positive for SARS‐CoV‐2, while for cats, the rate was 1.55%. Infections in rabbits and ferrets were even less common, at less than 1%. These results support previous research indicating the infrequency of natural infections in companion animals. The review also includes updated studies that involved various pets, such as cats, dogs, ferrets, and rabbits. The majority of the studies analyzed were primarily concerned with screening pets that visited veterinary clinics, regardless of whether they showed any specific signs of SARS‐CoV‐2 infection. Only a limited number of studies investigated infections in animals suspected of being in contact with owners or other animals that had COVID‐19 or were exhibiting symptoms. The most common variant identified among the SARS‐CoV‐2 variants in the reviewed studies was B.1.1.7 (alpha), followed by B.1.617.2 (delta), B.1.526 (Iota), and others. The emergence of these variants raises concerns about their potential for increased transmissibility and virulence, highlighting the importance of ongoing monitoring of SARS‐CoV‐2 infections in both humans and animals. Furthermore, most of the reviewed studies indicated that infected pets either showed no symptoms or experienced mild symptoms. This aligns with previous reports suggesting that animals infected with SARS‐CoV‐2 generally have less severe illness compared to humans. However, it is essential to recognize the possibility of severe illness or death in animals, particularly those with underlying health conditions. Continuous surveillance of SARS‐CoV‐2 infections in companion animals is crucial for better understanding the virus's epidemiology in animals and developing effective strategies to protect both animal and human health.

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“…Sin embargo, países con gran incidencia de casos de COVID-19, como India y Rusia, no han reportado oficialmente ningún caso hasta el momento de la escritura de este artículo (7). En Colombia, los reportes se limitan a un único caso clínico animal (perro), con sintomatología asociada, cuyo estudio filogenético determinó que se trataba de una infección por la variante de interés epidemiológico (VOI) Iota SARS-CoV-2 (Lineage B.1.526) (8). No obstante, se requiere vigilancia epidemiológica activa y continua de las mascotas de las personas con COVID, como se hace en otros países como China, Francia, España, Reino Unido, Estados Unidos y, a nivel latinoamericano, México, Brasil, Argentina, Chile y Uruguay (7).…”

Section: Introductionunclassified

Infección natural por SARS-CoV-2 en gatos y perros domésticos de personas con diagnóstico de COVID-19 en el Valle de Aburrá, Antioquia

Cabrera

González-Álvarez

Gutiérrez³

et al. 2022

biomedica

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Introducción. El síndrome respiratorio agudo grave causado por el nuevo coronavirus SARSCoV-2 es causa de la emergencia sanitaria por la pandemia de COVID-19. Si bien el humano es el el principal huésped vulnerable, en estudios experimentales y reportes de infección natural, se han encontrado casos de zoonosis inversa de SARS-CoV-2 en animales.Objetivo. Evaluar la infección natural por SARS-CoV-2 en gatos y perros de propietarios con diagnóstico de COVID-19 en el Valle de Aburrá, Antioquia, Colombia.Materiales y métodos. La circulación del SARS-CoV-2 se evaluó por RT-qPCR y RT-PCR en muestras de frotis nasofaríngeos y orofaríngeos de gatos y perros cuyos propietarios se encontraban dentro del periodo de los 14 días de aislamiento. Los casos positivos se verificaron amplificando fragmentos de los genes RdRp, N y E; se secuenció el gen RdRp y se analizó filogenéticamente.Resultados. De 80 animales evaluados, seis gatos y tres perros fueron casos confirmados de infección natural por SARS-CoV-2. Los animales no presentaron signos clínicos y sus propietarios, que padecían la infección, reportaron únicamente signos leves de la enfermedad sin complicaciones clínicas. En el análisis de una de las secuencias, se encontró un polimorfismo de un solo nucleótido (SNP) con un cambio en la posición 647, con sustitución del aminoácido serina (S) por una isoleucina (I). Los casos se presentaron en los municipios de Caldas, Medellín y Envigado.Conclusiones. Se infiere que la infección natural en los gatos y perros se asocia al contacto directo con un paciente con COVID-19. No obstante, no es posible determinar la virulencia del virus en este huésped, ni su capacidad de transmisión zoonótica o entre especie.

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Human-to-dog Transmission of SARS-CoV-2 Lota Variant: Should COVID-19 Patients Avoid Close Contact with their Pets During Illness?

Cited by 5 publications

References 37 publications

First report and genome sequencing of SARS-CoV-2 in a cat (Felis catus) in Colombia

First report and genome sequencing of SARS-CoV-2 in a cat (Felis catus) in Colombia

An overview of SARS‐CoV2 natural infections in companion animals: A systematic review of the current evidence

Infección natural por SARS-CoV-2 en gatos y perros domésticos de personas con diagnóstico de COVID-19 en el Valle de Aburrá, Antioquia

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