Human to Human Transmission of <i>Brucella Melitensis</i>

Vigeant, Patrice; Mendelson, Jack H.; Miller, Mark A.

doi:10.1155/1995/909404

Cited by 16 publications

(11 citation statements)

References 8 publications

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“…The second most commonly reported transmission route was sexual, with a total of 10 cases . However, only two had microbiological confirmation in semen.…”

Section: Discussionmentioning

confidence: 99%

Human‐to‐human transmission of Brucella – a systematic review

Tuon

Gondolfo

Cerchiari

2017

Tropical Med Int Health

136

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Abstractobjective The most common form of transmitting human brucellosis is through contaminated food or direct contact with infected animals. Human-to-human transmission (HHT) has been described as isolated case reports. The aim of this systematic review was to describe all cases of HHT of human brucellosis reported in the medical literature.methods A literature search was conducted using PubMed, Scopus and Scielo databases using specific search terms published until March 2016. Two investigators independently determined study eligibility.All clinical data were evaluated to construct a table comprising the most important clinical aspects, age, gender, confirmed infection and detection method, transmission method and HHT confirmation and potential source of infection for human transmission. No statistical method was employed in this study.results The initial search resulted in 615 publications, but only 35 were included. 45 brucellosis HHT cases were identified. 61% of patients who acquired brucellosis from another human were <1 year old (newborn and breastfeeding). Other cases include sexual transmission, blood transfusion, bone marrow transplantation and aerosol from an infected patient. Most patients (40/45) presented symptoms upon diagnosis. Diagnostic tests included culture, molecular methods and serum testing.conclusion Human brucellosis is a disease liable to transmission between humans by placental barrier, lactation, sexual and tissues such as blood and bone marrow. The indication for screening in tissue banks, transplants, blood and pregnancy is not yet established.

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“…The second most commonly reported transmission route was sexual, with a total of 10 cases . However, only two had microbiological confirmation in semen.…”

Section: Discussionmentioning

confidence: 99%

Human‐to‐human transmission of Brucella – a systematic review

Tuon

Gondolfo

Cerchiari

2017

Tropical Med Int Health

136

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“…Brucellosis, which is caused by bacteria in the Brucellagenus, is one of the most important zoonoses worldwide and is considered a "forgotten, neglected zoonosis" by the WHO (World Health Organization 2014) [1]. Brucellosisis endemic in regions within Africa, Asia,and Latin America and other countries along the Mediterranean Sea [2,3].Human infections can occur due to the consumption of contaminated non-pasteurized milk or cheese, or by occupational exposure to infected animals or their carcasses, uterine secretions, or aborted fetuses [4]. While the mortality rate of brucellosis is low, the morbidity rate is much higher.…”

Section: Introductionmentioning

confidence: 99%

Genome Sequences of Brucella Melitensis Strains QH2019001 and QH2019005 Provides Insight Into Different Evolutionary Origins Within Qinghai Province, China

Zhao

et al. 2020

Preprint

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Abstract Background Brucellosis, which is cause by Brucella, is one of the most important zoonoses and is considered a “forgotten, neglected zoonosis” by the WHO. Methods Blood samples were isolated from two brucellosis males that were confirmed B. melitensis positive following multiple loci variable-number tandem repeat analysis (MLVA) and strains QH2019001 and QH2019005 were identified. Genomic DNA was extracted from these samples and whole genome sequencing (WGS) was performed. Next, SNP-based phylogenetic analysis was performed to compare the two strains to 94 B. melitensis strains (complete genome and draft genome) retrieved from online databases. Results The QH2019001 and QH2019005 strains were found to have differences in their variable-number tandem repeats. Phylogenetic examination of the 96 strains assigned them to 5 genotype groups, with QH2019001 and QH2019005 assigned to the same group, but to different subgroups; with the QH2019005 strain assigned to a new subgenotype, IIj. These findings were then combined to determine strain origin. Conclusions Utilizing a whole genome SNP-based approach highlights the diversity between B. melitensis strains, and it can facilitate the elucidation of different evolutionary histories. This approach also revealed that the QH2019005 is part of a new subgenotype with an ancient origin in the eastern Mediterranean Sea.

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“…Brucellosis, which is caused by bacteria in the Brucella genus, is one of the most important zoonoses worldwide and is considered a "forgotten, neglected zoonosis" by the WHO (World Health Organization 2014) [1]. This disease is endemic in regions within Africa, Asia, Latin America and other countries along the Mediterranean Sea [2,3]. Human infections can occur due to the consumption of contaminated nonpasteurized milk or cheese, or by occupational exposure to infected animals or their carcasses, uterine secretions, or aborted fetuses [4].…”

Section: Introductionmentioning

confidence: 99%

Molecular characteristics of Brucella melitensis isolates from humans in Qinghai Province, China

Zhao

et al. 2020

Preprint

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Background The prevalence of human brucellosis in Qinghai Province has been increasing rapidly, with confirmed cases distributed across 31 counties. However, the epidemiology of brucellosis transmission has not been fully elucidated. To characterize the two isolated strains, multiple locus variable-number tandem repeats analysis (MLVA) and whole-genome single-nucleotide polymorphism (SNP)-based approaches were employed. Methods Blood samples were isolated from two males that were confirmed B. melitensis positive following MLVA. Genomic DNA was extracted from these samples, and whole-genome sequencing (WGS) was performed. Next, SNP-based phylogenetic analysis was performed to compare the two strains to 94 B. melitensis strains (complete genome and draft genome) retrieved from online databases. Results The two Brucella isolates were identified as B. melitensis biovar 3 (QH2019001 and QH2019005) following conventional biotyping and were found to have differences in their variable number tandem repeats (VNTRs) using MLVA-16. Phylogenetic examination assigned the 96 strains to five genotype groups, with QH2019001 and QH2019005 assigned to the same group, but different subgroups. Moreover, the QH2019005 strain was assigned to a new subgenotype, IIj, within genotype II. These findings were then combined to determine the geographic origin of the two Brucella strains. Conclusions Utilizing a whole-genome SNP-based approach enabled differences between the two B. melitensis strains to be more clearly resolved, and facilitated the elucidation of their different evolutionary histories. This approach also revealed that QH2019005 is a member of a new subgenotype (IIj) with an ancient origin in the eastern Mediterranean Sea.

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Human to Human Transmission of Brucella Melitensis

Cited by 16 publications

References 8 publications

Human‐to‐human transmission of Brucella – a systematic review

Human‐to‐human transmission of Brucella – a systematic review

Genome Sequences of Brucella Melitensis Strains QH2019001 and QH2019005 Provides Insight Into Different Evolutionary Origins Within Qinghai Province, China

Molecular characteristics of Brucella melitensis isolates from humans in Qinghai Province, China

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