Human transferrin as a source of iron for Streptococcus intermedius

Brochu, Vicky

doi:10.1016/s0378-1097(98)00321-8

Cited by 3 publications

(4 citation statements)

References 14 publications

(25 reference statements)

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“…The utilization of ferrous (Fe 2+ ) iron was thus considered as a factor in pathogenesis. Brochu et al (1998) demonstrated that ferrous sulfate stimulated the growth of S. intermedius (Brochu et al 1998). Our findings demonstrated that a concentration of ferrous sulfate below 10 mmol l )1 did not affect the growth of most bacterial strains tested.…”

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confidence: 51%

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Metal-ion susceptibility of oral bacterial species

Youravong

Carlén

Teanpaisan

et al. 2011

Letters in Applied Microbiology

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Summary Aims: This study aimed to evaluate the effect of lead (Pb) on growth of bacterial species related to dental diseases in vitro. Methods and Results: The effects of lead acetate on representative species of the oral flora were examined at 0·1–10 mmol l−1 and compared with the effect of silver nitrate and ferrous sulfate. The minimal inhibitory concentration of lead acetate was between 0·15 and 5 mmol l−1 for the bacterial strains tested. The minimal bactericidal concentration of lead acetate for most oral species was detected in the range of 5–10 mmol l−1. Silver nitrate at a concentration of 1·25 mmol l−1 was sufficient to exhibit antibacterial activity against almost all bacteria tested. Ferrous sulfate had the lowest effect. Conclusions: The study indicated a general antimicrobial effect of lead on oral bacterial species in the range of 0·15–10 mmol l−1. The toxicity of silver nitrate was the highest, whereas that of ferrous sulfate was the lowest. Gram‐positive species had a tendency to be less susceptible for metals than Gram‐negatives. Significance and Impact of the Study: The study shows that it is possible that microbiological changes may occur in the dental plaque in children because of toxic exposure of environmental lead.

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confidence: 51%

“…The utilization of ferrous (Fe 2+ ) iron was thus considered as a factor in pathogenesis. Brochu et al. ( 1998) demonstrated that ferrous sulfate stimulated the growth of S. intermedius (Brochu et al.…”

Section: Discussionmentioning

confidence: 99%

Metal-ion susceptibility of oral bacterial species

Youravong

Carlén

Teanpaisan

et al. 2011

Letters in Applied Microbiology

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“…The specific biological mechanism by which transferrin allele is related to differences in S. zooepidemicus infection in ponies is not known. It is possible that there is a direct link between pathogenesis of S. zooepidemicus infection and transferrin allele similar to that identified for S. intermedius by Brochu et al (1998). These authors demonstrated in vitro that S. intermedius was able to acquire iron in iron-restricted conditions by causing its release from transferrin by rapidly decreasing the pH of the culture medium.…”

Section: Transferrin Allelesmentioning

confidence: 65%

Evidence for transferrin allele as a host‐level risk factor in naturally occurring equine respiratory disease: a preliminary study

Newton

Wood

Chanter³

2007

Equine Veterinary Journal

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“…There have been several theoretical or empirical reasons why Fe has not been advised in populations where infections are endemic. First, experimental studies showed an increased bacterial growth when Fe was added to the culture medium (Andrews, 1998;Brochu et al 1998). Second, there were reports of increased intestinal parasitic infection during refeeding of refugees, although these studies were observational and there were confounding variables (Murray et al 1978).…”

Section: Ironmentioning

confidence: 99%

Malnutrition, morbidity and mortality in children and their mothers

Tomkins

2000

Proc. Nutr. Soc.

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While being underweight or stunted is recognized as an important risk factor for increased prevalence and severity of infection and high mortality rates, there is increasing evidence for an independent role for micronutrient deficiency. Improving vitamin A status reduces mortality among older infants and young children and reduces pregnancy-related mortality; it also reduces the prevalence of severe illness and clinic attendance among children. Improving Zn status reduces morbidity from diarrhoeal and respiratory infection. Treatment of established infection with vitamin A is effective in measles-associated complications, but is not as useful in the majority of diarrhoeal or respiratory syndromes. Zn supplements, however, have significant benefit on the clinical outcome of diarrhoeal and respiratory infections. Concerns that Fe supplements might increase morbidity if given in malarious populations appear to be decreasing, in the light of new studies on Fe supplements showing improved haemoglobin without an increase in morbidity. Breast-feeding, well known to protect against diarrhoea, is also important in protecting against respiratory infection, especially in the young infant. Transmission of human immunodeficiency virus (HIV) in breast milk is recognized, but new data showing reduced transmission in infants who receive exclusive breast-feeding rather than mixed feeding reinforces the importance of promoting this practice in areas where environmental contamination precludes the safe use of other infant feeding regimens. The presence of subclinical mastitis, now recognized to occur in approximately 20 % of mothers in several developing countries, has been shown to increase the concentration of HIV in breast milk. Preliminary findings suggest that the prevalence of subclinical mastitis is reduced by dietary supplements containing antioxidants. Governments and international agencies now have a strong scientific basis to be much more active and innovative in the introduction of focused nutrition interventions especially micronutrients, for the control of infection.

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Human transferrin as a source of iron for Streptococcus intermedius

Cited by 3 publications

References 14 publications

Metal-ion susceptibility of oral bacterial species

Metal-ion susceptibility of oral bacterial species

Evidence for transferrin allele as a host‐level risk factor in naturally occurring equine respiratory disease: a preliminary study

Malnutrition, morbidity and mortality in children and their mothers

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