Human triploidy: Association with partial hydatidiform moles and nonmolar conceptuses

Szulman, A. E.; Philippe, E; Boué, J; Boué, A

doi:10.1016/s0046-8177(81)80259-6

Cited by 163 publications

(41 citation statements)

References 19 publications

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“…For example, diandric triploid pregnancies in most cases are associated with normal fetal growth, marked syncytiotrophoblastic hyperplasia and villus hydatidiform changes in the placenta resulting in partial moles. In contrast, digynic triploid pregnancies show marked fetal growth restriction and with a small and noncystic placenta [7,8]. While the fetus in our case has some of the features of a typical triploid such as holoprocencephaly, hypertelorism, hypoplastic eyes, bilateral cleft lip and palate, syndactyly of third and fourth fingers, multicystic kidney, atrophy of the adrenal glands and thymus, the placenta did not show the typical features such as hydatidiform changes and trophoblastic hyperplasia.…”

Section: Discussioncontrasting

confidence: 64%

Sonographic, Pathologic andKaryotypic Findings in a Rare Case of Placenta fenestrata

Linhart

Grafe²,

Saade

et al. 2004

Fetal Diagn Ther

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Abnormalities of placental shape are occasionally seen on ultrasound. They have not been reported to be associated with abnormalities in fetal anatomy and karyotype. Here, we report on a rare case of placenta fenestrata with triploid karyotype. A 15-year-old patient presented at 21 weeks and 3 days gestation for ultrasound evaluation following an abnormal triple screen and abnormal ultrasound. Multiple fetal abnormalities were noted as well as several cystic areas with pulsatile flow on Doppler ultrasound in the placenta. After termination of the pregnancy, a rare abnormality in the placental shape, placenta fenestrata, was noted. The fetal karyotyping showed a triploid karyotype. This is the first reported case of placenta fenestrata diagnosed on ultrasound. In addition, this is also the first reported case of karyotype abnormality associated with abnormality of placental shape.

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Section: Discussioncontrasting

confidence: 64%

Sonographic, Pathologic andKaryotypic Findings in a Rare Case of Placenta fenestrata

Linhart

Grafe²,

Saade

et al. 2004

Fetal Diagn Ther

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“…In humans, triploid fetuses are usually retarded in growth and have severe anatomic defects of the head, heart, and extremities [46]. The development of rat triploid embryos FIG.…”

Section: Ploidy Of Ppn-derived Embryosmentioning

confidence: 99%

Pronuclear Location Before the First Cell Division Determines Ploidy of Polyspermic Pig Embryos1

Han

Wang

Abeydeera

et al. 1999

Biology of Reproduction

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Polyspermy occurs frequently in the fertilization of mammalian eggs, but little is known about whether polyspermic eggs have developmental ability in vitro or in vivo. We previously reported that poly-pronuclear (PPN; 3 or more pronuclei) pig eggs developed normally to the blastocyst stage despite having fewer inner cell mass cell numbers as compared to blastocysts derived from two-pronuclear (2PN) eggs. Here it is shown that most PPN pig eggs have abnormal cleavage patterns (having 3 or more cells) in the first cell division and retarded development of pronuclei prior to syngamy as compared to 2PN eggs. Most blastocysts (14 of 18) that developed from PPN eggs showed abnormal ploidy (were haploid, triploid, and tetraploid) whereas 20 of 22 blastocysts derived from 2PN embryos were diploid. The size and morphology of most Day 40 fetuses that developed from PPN eggs appeared to be normal. Of 8 Day 40 fetuses analyzed, 1 was triploid (XXY) and another was a mosaic with both diploid (XX) and tetraploid cells (frequency of less than 10%, XXXX), and the others were diploid. Anomalies of chromosomal composition were not detected in these fetuses. Five live piglets and one dead piglet were born from two recipients of PPN eggs. It is proposed that not all pronuclei of PPN pig eggs participate in syngamy, resulting in diploid cells in the conceptus. Our data suggest that there are two types of pronuclei location in polyspermic pig eggs and that the resulting ploidy is determined at the zygote stage before the first cell division according to pronuclear location.

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“…8 DNA analysis confirmed the androgenic mechanism. 9 Capillary vessels are found in the interstitium of molar vesicles.…”

Section: Partial Hydatidiform Molementioning

confidence: 64%

Trophoblastic Diseases

Varga¹,

Honemeyer²,

Maeda³

2012

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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Trophoblastic diseases are mainly hydatidiform mole and choriocarcinoma, where the latter is usually the sequela of molar pregnancy and malignant systemic disease with general metastases destructing various tissues and organs till she die. High level urinary hCG, real-time B-mode and color Doppler imaging detect hydatidiform mole in early gestation, postmolar persistent trophoblastic disease is diagnosed by urinary hCG, and treated by prophylactic chemotherapy against choriocarcinoma. Uterine choriocarcinoma and its metastases are diagnosed by hCG and B-mode, color and power Doppler and 3D images detecting rich tumor blood flow. Most choriocarcinoma was effectively treated by primary chemotherapy with methotrexate, etoposide, etc. Until complete remission where hCG is lower than the cut-off level. Placental site trophoblastic tumor (PSTT) and epitheloid trophoblastic tumor (ETT) were low in hCG level and high in human placental lactogen (hPL), and show rich tumor blood flow in color Doppler ultrsound. Nongestational choriocarcinoma is rare and usually chemotherapy resistant.

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Human triploidy: Association with partial hydatidiform moles and nonmolar conceptuses

Cited by 163 publications

References 19 publications

Sonographic, Pathologic andKaryotypic Findings in a Rare Case of Placenta fenestrata

Sonographic, Pathologic andKaryotypic Findings in a Rare Case of Placenta fenestrata

Pronuclear Location Before the First Cell Division Determines Ploidy of Polyspermic Pig Embryos1

Trophoblastic Diseases

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