Human Trophoblast Cell-Derived Extracellular Vesicles Facilitate Preeclampsia by Transmitting miR-1273d, miR-4492, and miR-4417 to Target HLA-G

Li, Lijing; Li, Xiongying; Zhu, Yonghua; Li, Lei; Wu, Yan; Ying, Jingxia; Li, Yanyan; Chen, Jingjing

doi:10.1007/s43032-022-00939-6

Cited by 11 publications

(7 citation statements)

References 36 publications

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“…MiR-1273d was found to be involved in hypoxia, immune, and inflammatory pathways. 33 MiR-1303 and miR-3064-5p regulate the permeability of the blood–brain barrier, 34 , 35 increasing the risk of viral infection or damage to the brain by toxic substances, ultimately leading to pathological changes in the central nervous system. MiR-4428 is involved in the PI3K-PKB signaling pathway that promotes cell survival.…”

Section: Discussionmentioning

confidence: 99%

The Correlation Between Peripheral Blood MicroRibonucleic Acid Expression Level and Personality Disorder in Patients with Schizophrenia

Wei,

Kong,

Zhu

et al. 2024

ALPHA PSYCHIATRY

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Objective: Schizophrenia patients often have personality disorders; schizophrenia patients with personality disorders are more difficult to treat and have a worse prognosis. Early identification of this group of patients and early intervention can achieve better prognosis. Therefore, it is very important to explore effective biomarkers and early diagnosis for the prognosis of schizophrenia. The primary purpose of this paper is to explore the relationship between plasma miRNA expression level and personality disorder with schizophrenia. Methods: Gene microarrays in miRNA files were employed, and the plasma of peripheral blood of 82 schizophrenic patients and 43 healthy control subjects were examined. Real-time reverse transcription polymerase chain reaction detection were performed to explore the results. Spearman correlation analysis was used to analyze the correlation between expression level of miRNAs and Personality Diagnosis Questionnaire-4 score. Results: The results showed that miR-1273d, miR-1303, miR-3064-5p, miR-3131, miR-3687, miR-4428, miR-4725-3p, and miR-5096 were up-regulated in schizophrenic patients. Compared to healthy control subjects, the difference was statistically significant ( P < .05). Schizophrenic patients with schizoid, paranoid, schizotypal, and obsessive compulsive traits had negative correlation with miR-1303, miR-3131, miR-4428, and miR-5096 expression level ( r = −0.40 to −0.62, P < .05); there were no significant differences in the other miRNAs. Correlation with other personality traits was not significant ( P > .05). The stepwise regression analysis indicated that miR-5096, miR-3131, and miR-1273d have a significant predictive effect on the schizoid trait ( P < .01). MiR-4428 and miR-1303 had a significant predictive effect on the schizotypal trait ( P < .01). MiR-5096, miR-4428, and miR-4725-3P had a significant predictive effect on the paranoid trait ( P < .05). MiR-4428, miR-1303, and miR-5096 had a significant predictive effect on the obsessive compulsive trait ( P < .05). Conclusion: The expression levels of miR-1273d, miR-1303, miR-3064-5p, miR-3131, miR-3687, miR-4428, miR-4725-3p, and miR-5096 were up-regulated in the peripheral blood of patients with schizophrenia, and these miRNAs are expected to be diagnostic biomarkers for accurate diagnosis of schizophrenia. The expression levels of miR-1303, miR-3131, miR-1273d, miR-4428, miR-4725-3p, and miR-5096 have significant predictive effects on personality disorder in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

The Correlation Between Peripheral Blood MicroRibonucleic Acid Expression Level and Personality Disorder in Patients with Schizophrenia

Wei,

Kong,

Zhu

et al. 2024

ALPHA PSYCHIATRY

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“…EVs derived from hypoxic trophoblast cells regulate chondroitin polymerizing factor by delivering miR-150–3p to inhibit endothelial cell proliferation, migration, and angiogenesis [ 53 ]. EVs secreted by trophoblast cells under hypoxic conditions transferred miR-1273d, miR-4492, and miR-4417 to coordinate immune- and inflammation-related pathways to promote PE development [ 54 ]. Exos-MSC may alleviate the apoptosis of PE and promote the angiogenesis of placental tissue [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Huc-MSC-derived exosomal miR-144 alleviates inflammation in LPS-induced preeclampsia-like pregnant rats via the FosB/Flt-1 pathway

Sun,

Zhang

2024

Heliyon

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“…Also, placental tissues from PE patients showed a significantly decreased Foxp3 and significantly increased expression of miR-210, indicating a possibly positive co-regulation among them [78]. In vitro assays showed that under hypoxic conditions, human trophoblast cell-derived extracellular vesicles release miR-1273d, miR-4492, and miR-4417 to target HLA-G, mediating immune-and inflammation-related pathways and, consequently, triggering the development of PE [79].…”

Section: Mirnas In the Immune Dysregulation Of Preeclampsiamentioning

confidence: 97%

The Role of ncRNAs in the Immune Dysregulation of Preeclampsia

Mora-Palazuelos,

Villegas-Mercado,

Avendaño-Félix

et al. 2023

IJMS

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The main complications causing practically 75% of all maternal deaths are severe bleeding, infections, and high blood pressure during pregnancy (preeclampsia (PE) and eclampsia). The usefulness of ncRNAs as clinical biomarkers has been explored in an extensive range of human diseases including pregnancy-related diseases such as PE. Immunological dysregulation show that the Th1/17:Th2/Treg ratio is “central and causal” to PE. However, there is evidence of the involvement of placenta-expressed miRNAs and lncRNAs in the immunological regulation of crucial processes of placenta development and function during pregnancy. Abnormal expression of these molecules is related to immune physiopathological processes that occur in PE. Therefore, this work aims to describe the importance of miRNAs and lncRNAs in immune dysregulation in PE. Interestingly, multiple ncRNAS are involved in the immune dysregulation of PE participating in type 1 immune response regulation, immune microenvironment regulation in placenta promoting inflammatory factors, trophoblast cell invasion in women with Early-Onset PE (EOPE), placental development, and angiogenesis, promotion of population of M1 and M2, proliferation, invasion, and migration of placental trophoblast cells, and promotion of invasion and autophagy through vias such as PI3K/AKT/mTOR, VEGF/VEGFR1, and TLR9/STAT3.

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Human Trophoblast Cell-Derived Extracellular Vesicles Facilitate Preeclampsia by Transmitting miR-1273d, miR-4492, and miR-4417 to Target HLA-G

Cited by 11 publications

References 36 publications

The Correlation Between Peripheral Blood MicroRibonucleic Acid Expression Level and Personality Disorder in Patients with Schizophrenia

The Correlation Between Peripheral Blood MicroRibonucleic Acid Expression Level and Personality Disorder in Patients with Schizophrenia

Huc-MSC-derived exosomal miR-144 alleviates inflammation in LPS-induced preeclampsia-like pregnant rats via the FosB/Flt-1 pathway

The Role of ncRNAs in the Immune Dysregulation of Preeclampsia

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