Human Tumors Heterotransplanted in Nude Mice and Rats

Progressive growth of a human pleural mesothelioma xenografted to athymic rats and mice

“…In contrast, the latency time for tumour growth in our tumour seems to be significantly shorter in rats than in mice (Figure 2). This is in agreement with observations that some tumours may grow significantly faster in rats than in mice (Giovanella et al, 1984 (Brunton & Wheldon, 1978). Theoretical calculations of the maximal achievable tumour volumes of human tumour xenografts in mice using the Gompertz equation indicate maximal volumes to be in the range of those actually found in mouse tumours (Rofstad et al, 1982).…”

“…The take rates for cells from previously serially transplantable tumour lines or from primary explants have been reported to be equal in rats and mice (Sawada et al, 1982;Matthews et al, 1982). However, in a few studies the take rates have been observed to be lower in nude rats (Maruo et al, 1982;Giovanella et al, 1984). In addition, the take rate (Sawada et al, 1982;Maruo et al, 1982;Drewinko et al, 1986) and growth rate (Maruo et al, 1982) of xenografts in nude rats have been observed to decrease with increasing age in the animal.…”

Localised hyperthermia in rodent models using an MRI-compatible high-intensity focused ultrasound system

“…This is the simplest approach to implement but suffers from poor localisation and non-uniform heating since the approach relies on thermal conduction from the skin surface. Radiofrequency (RF) and microwave devices have also been used for small animal hyperthermia studies [15–22]. In RF hyperthermia treatments the target tissue is capacitively coupled with multiple applicators connected to an RF generator.…”

Stable heat‐resistant clones selected from wild‐type and surface variants of B‐16 melanoma

“…However, most attempts to isolate stable H R cell lines have proved unsuccessful (Giovanella et al, 1979;Hahn, 1982). The present successful isolation of a large family of stable H R variants from the wild-type B-16 melanoma cells and three of their surface variant lines thus constitutes a major advance.…”

“…In all cases, the parent lines were "normal". To our knowledge, no reports exist that describe the isolation of HR mutants from known malignant cells (Hahn, 1982;Giovanella et al, 1979). Yet, this is a subject of considerable importance, because localized hyperthermia is rapidly becoming an accepted mode of treating some tumors.…”