Human Tumours in Cortisone-Treated Mice

Abstract

Images Figs. 1-5 Fig. 6 Figs. 7-10

The cellular reactions to heterologous, homologous and autologous skin implanted into brain

“…It had been shown earlier that in the same way rat tissues implanted into the chick embryo could be killed if fragments of adult chicken spleen were inoculated with the implant (Murphy, 1914). It is thus very probable that the particular mouse tumours used by Murphy and Sturm were poorly antigenic both in rat and mouse, and had presumably undergone considerable alteration by either loss of chromosomes or antigen deletion, changes that have been shown by Iversen (1956) and by Korngold (1956) to occur when tumours are transplanted into other species. Any immunological response stimulated by this type of tissue is, therefore, likely to be a poor reflection of that which could occur with tissue with the full complement of antigens.…”

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SHIRAI (1921) and Murphy and Stunn (1923) showed that heterologous tumour grafts grew successfully in the brain. Repeated reports of the success, or partial success, of such transplants (Seibert, 1928;Loeb, 1930;Greene, 1951 Greene, , 1957Chesterman, 1959) suggest that there may be a special feature of brain, unlike other sites, that allows the successful survival and ultimate growth of implanted tissue. Greene and Harvey (1964a and b) used this technique to study malignant human and animal tumours, but they have not recorded the cellular reactions of the host towards the graft.

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