Human Ultrasound Neuromodulation: State of the Art

Beisteiner, Roland

doi:10.3390/brainsci12020208

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…[89] TUS is a promising non-invasive technology that has the potential to advance neuroscience research to become a new type of non-invasive treatment. [89,90] It has the advantages of higher spatial resolution, deeper tissue penetration, and good compatibility with other technologies such as EEG, functional magnetic resonance imaging, and TMS. Despite advances in ultrasound neuroregulation, the full potential of this technique has yet to be realized due to the limited exploration of its vast parameter space.…”

Section: Input-type Bcismentioning

confidence: 99%

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Exploring the Intersection of Brain–Computer Interfaces and Quantum Sensing: A Review of Research Progress and Future Trends

Liao,

Yang,

Tao

et al. 2023

Adv Quantum Tech

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Brain–computer interfaces (BCIs) can revolutionize how humans interact with technology, but several scientific and technological challenges must be addressed to realize their full potential. Recent developments in quantum‐based sensing methods offer promising solutions to some of these challenges. This review provides an overview of the progress, challenges, and prospects of BCIs research and discuss the feasibility of integrating quantum sensor technology in BCI systems. The applications of quantum sensing in BCIs research are reviewed and the solution based on quantum sensor technology to overcome some of the challenges associated with BCI systems is proposed. The potential of quantum sensor technology for the future development of BCIs is emphasized. Overall, this review highlights quantum sensor technology's significant potential for future development of BCI.

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Section: Input-type Bcismentioning

confidence: 99%

“…[ 89,90] tPBM -Good tolerance -Real-time -Non-invasive -So far, the information that can be determined is still very limited.…”

Section: Quantum Sensing Technology For Bcismentioning

confidence: 99%

Exploring the Intersection of Brain–Computer Interfaces and Quantum Sensing: A Review of Research Progress and Future Trends

Liao,

Yang,

Tao

et al. 2023

Adv Quantum Tech

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“…Meanwhile, ultrasound surgery and, just recently, ultrasound neuromodulation have entered routine clinical therapy. [3,4] The rapidly DOI: 10.1002/advs.202205634 ongoing methodological and clinical progress opens completely novel perspectives for ultrasound brain therapy. This is important since brain diseases are one of the most urgent problems in our rapidly ageing society.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Neuromodulation as a New Brain Therapy

2023

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Within the last decade, ultrasound has been “rediscovered” as a technique for brain therapies. Modern technologies allow focusing ultrasound through the human skull for highly focal tissue ablation, clinical neuromodulatory brain stimulation, and targeted focal blood‐brain‐barrier opening. This article gives an overview on the state‐of‐the‐art of the most recent application: ultrasound neuromodulation as a new brain therapy. Although research centers have existed for decades, the first treatment centers were not established until 2020, and clinical applications are spreading rapidly.

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“…Recent developments in novel transcranial ultrasound techniques have enabled new possibilities for precise neuromodulation as well as clinical add-on treatment [ 1 – 3 ]. Advantages over electromagnetic techniques concern precise targeting independent from pathological brain conductivities and non-invasive stimulation deep in the brain [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Functional Specificity of TPS Brain Stimulation Effects in Patients with Alzheimer’s Disease: A Follow-up fMRI Analysis

2022

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Introduction Transcranial pulse stimulation (TPS) has been recently introduced as a novel clinical brain stimulation technique based on highly focused ultrasound pressure pulses. In a first pilot study on clinical effects of navigated and focused ultrasound neuromodulation, a dichotomy of functional effects was found: patients with Alzheimer’s disease improved cognition and language but deteriorated with visuo-constructive functions. Methods We analyzed changes in functional connectivity measured with functional magnetic resonance imaging (fMRI) using graph analysis of a visuo-constructive network in 18 patients with Alzheimer’s disease. We calculated the network’s global efficiency and tested for correlation with visuo-constructive test scores to explain this dichotomy. Results Important visuo-constructive network nodes were not stimulated in the pilot setting and correspondingly global efficiency of a visuo-constructive network was decreased after TPS therapy, compatible with a natural progress of the disease. A correlation between visuo-constructive scores and changes in global efficiency was found. Conclusion Results argue for a high functional specificity of ultrasound-based neuromodulation with TPS.

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Human Ultrasound Neuromodulation: State of the Art

Abstract: The first human applications of ultrasound in medicine date back to 1939, when Reimar Pohlmann (Berlin, Germany) published data on therapy of neuralgia with ultrasound [...]

Cited by 4 publications

References 18 publications

Exploring the Intersection of Brain–Computer Interfaces and Quantum Sensing: A Review of Research Progress and Future Trends

Exploring the Intersection of Brain–Computer Interfaces and Quantum Sensing: A Review of Research Progress and Future Trends

Ultrasound Neuromodulation as a New Brain Therapy

Functional Specificity of TPS Brain Stimulation Effects in Patients with Alzheimer’s Disease: A Follow-up fMRI Analysis

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