2020
DOI: 10.1007/s00402-020-03349-y
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Human umbilical cord blood-derived mesenchymal stem cell implantation for osteoarthritis of the knee

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Cited by 34 publications
(75 citation statements)
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“…Previous case series about HTO with hUCB-MSCs reported good clinical outcomes and cartilage regeneration. 15,19,20 The current study agreed with these results, with good clinical outcomes and JSW increments in elderly patients.…”
Section: Discussionsupporting
confidence: 88%
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“…Previous case series about HTO with hUCB-MSCs reported good clinical outcomes and cartilage regeneration. 15,19,20 The current study agreed with these results, with good clinical outcomes and JSW increments in elderly patients.…”
Section: Discussionsupporting
confidence: 88%
“…After saline drainage, off-the-shelf hUCB-MSC product, Cartistem (MEDIPOST, Seongnam, South Korea), was applied. This product consists of 1.5 mL hUCB-MSCs (7.5 × 10 6 cells/vial) and 4% hyaluronic acid hydrogel, and it was approved by the Korea Food and Drug Administration in 2012 and is used for cartilage regeneration 15,19,20,25 (Fig. 1).…”
Section: Surgical Procedures and Postoperative Rehabilitation Protocolmentioning
confidence: 99%
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“…Recent studies have demonstrated that the therapeutic effects of MSCs are mediated by their paracrine activity and that MSCs behave similarly to drugs with complex functions in the microenvironment of various diseases. This suggests the possibility of developing a treatment strategy with MSCs for refractory diseases [ 1 , 2 ]. Previously, intra-articular administration of allogeneic MSCs in a pain-induced monoiodoacetate (MIA)-injected rat arthritis model was found to increase the expression of tumor necrosis factor (TNF)-stimulated gene 6, which has an anti-inflammatory action on cartilage, and decrease the matrix-degrading enzyme disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…Previously, intra-articular administration of allogeneic MSCs in a pain-induced monoiodoacetate (MIA)-injected rat arthritis model was found to increase the expression of tumor necrosis factor (TNF)-stimulated gene 6, which has an anti-inflammatory action on cartilage, and decrease the matrix-degrading enzyme disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) [ 3 ]. This finding suggests that MSCs are capable of not only acting similar to pharmacological drugs at lesion sites to relieve inflammation, suppress pain, and participate in immune responses but also inhibiting degenerative molecule expression involved in OA pathogenesis [ 1 , 2 , 3 ].…”
Section: Introductionmentioning
confidence: 99%