Human umbilical cord blood serum attenuates gentamicin‐induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats

Abstract

is an aminoglycoside antibiotic. Despite its clinical effects, its application has been restricted due to adverse side effects. The application of this antibiotic is a prevalent cause of acute renal failure in about 10 to 20% of the consumers. 1 Apart from the renal effects, GM also has hepatic effects that induce apoptosis and increase the activity of the reactive oxygen species (ROS). 2 Acute hepatic deficiencies caused by medication are associated with the rapid loss of hepatic function as well as high mortality rate. Currently, for the advanced conditions of the disease, the only alternative is the liver transplantation which due to the shortage of donors and rejection problems presents itself as a huge challenge. 3 However, in recent years, cell therapies utilizing stem cells-due to their inherent ability to repair damaged tissues and organs-have shown remarkable progress in advancing the recovery of damage and disability of organs and tissues. 4 Having said that, the use of stem cells and their administration to patients entail serious risks and side effects such

Tubulin‐binding peptide RR‐171 derived from human umbilical cord serum displays antitumor activity against hepatocellular carcinoma via inducing apoptosis and activating the NF‐kappa B pathway

“…Exosomes derived from umbilical cord blood stem cells have been reported to ameliorate IL‐6‐mediated acute liver injury 22 . Human umbilical cord serum can reduce gentamicin‐induced hepatotoxicity by restoring peripheral oxidative damage and the inflammatory response in rats 23 . Accidentally, we found that umbilical cord serum has a certain inhibitory effect on HCC cells.…”

“…22 Human umbilical cord serum can reduce gentamicin-induced hepatotoxicity by restoring peripheral oxidative damage and the inflammatory response in rats. 23 Accidentally, we found that umbilical cord serum has a certain inhibitory effect on HCC cells. To further analyse human umbilical cord serum and verify its effect on tumour biology, we collected and measured the bioactivity of human umbilical cord serum by proteomics biotechnology.…”