Human umbilical cord mesenchymal stem cells (hUCMSCs) promotes the recovery of ovarian function in a rat model of premature ovarian failure (POF)

Zhang, Xunyi; Zhang, Lina; Li, Ying; Yin, Zhe; Feng, Yun; Ji, Yao

doi:10.1080/09513590.2021.1878133

Cited by 16 publications

(14 citation statements)

References 24 publications

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“…The levels of sex hormones, oestrous cycle, and reproductive potential of the treated rats were recovered to some extent, and some transplanted rats even recovered fertility. Other studies also showed the positive effects of hUCMSCs on premature ovarian failure and ovarian dysfunction in a rat model ( 60 , 61 , 62 , 63 , 64 ). In the current study, hUCSC was better than all groups in terms of intra-abdominal adhesions.…”

Section: Discussionmentioning

confidence: 82%

Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study

Aygün¹,

Tümentemur²

2022

J Turkish German Gynecol Assoc

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Objective: This study aimed to compare the effects of human umbilical cord mesenchymal stem cells (hUCMSCs), amniotic fluid (AF), and a combination of both on the uterus and ovaries in a rat model of abdominal adhesions. Material and Methods: This study was designed as a controlled study. Four groups, each consisting of six rats, were randomly formed. One group was designated as the control (CNT). hUCMSCs - applied (hUCSC), AF-applied (AMN), and a combination of both (hUCSC + AMN) were the experimental groups. All rats were given intraperitoneal talc powder to create adhesions. After 21 days, animals in experimental groups were further treated with hUCMSC, AF or a combination of these. Results: There was a statistically significant difference in primordial follicle count, endometrial gland number, and endometrial blood vessel count (p<0.05). AMN provided the best results in the endometrial vessel and primordial follicle count. The average endometrial gland count in AMN and hUCSC + AMN was similarly higher than CNT and hUCSC alone. Conclusion: There were significantly higher for counts for endometrial glands, endometrial blood vessels, and primordial follicles in the hUCSC, AMN and hUCSC + AMN groups compared to controls. Animals in the AMN group had the best result for endometrial vessel and highest primordial follicle count.

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Section: Discussionmentioning

confidence: 82%

Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study

Aygün¹,

Tümentemur²

2022

J Turkish German Gynecol Assoc

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“…Zhang et al. demonstrated that HUCMSCs transplantation improves the disorder of sexual cycle, modulates the serum hormone expression to a better state and restores ovarian function in a rat model of premature ovarian failure with no severe adverse effects [ 36 ]. To verify the immunogenicity of allogeneic MSCs, we injected HUCMSCs isolated from human umbilical cord into the right gastrocnemius muscle of nude mice and KM mice.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of human umbilical cord mesenchymal stem cells in early traumatic osteonecrosis of the femoral head

Zhao¹,

Meng²,

Liao³

et al. 2022

Journal of Orthopaedic Translation

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“…The third method is stem cell delivery. Mesenchymal stem cells (MSCs) treatment in POF increased the number of follicles, restored plasma sex hormone levels (Zhang et al, 2021b), reduced ovarian inflammation and reduced granulosa cell apoptosis (Ling et al, 2017;Deng et al, 2021). Stem cells are mainly administered by caudal intraperitoneal injection or ovarian orthotopic injections Woo et al, 2012).…”

Section: The Application Of Hydrogels In Pofmentioning

confidence: 99%

Applications of Hydrogels in Premature Ovarian Failure and Intrauterine Adhesion

Zhang

Ding²,

Duan³

et al. 2022

Front. Mater.

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Premature ovarian failure (POF) and intrauterine adhesion (IUA) that easily lead to reduced fertility in premenopausal women are two difficult diseases to treat in obstetrics and gynecology. Hormone therapy, in vitro fertilization and surgical treatments do not completely restore fertility. The advent of hydrogels offers new hope for the treatment of POF and IUA. Hydrogels are noncytotoxic and biodegradable, and do not cause immune rejection or inflammatory reactions. Drug delivery and stem cell delivery are the main application forms. Hydrogels are a local drug delivery reservoir, and the control of drug release is achieved by changing the physicochemical properties. The porous properties and stable three-dimensional structure of hydrogels support stem cell growth and functions. In addition, hydrogels are promising biomaterials for increasing the success rate of ovarian tissue transplantation. Hydrogel-based in vitro three-dimensional culture of follicles drives the development of artificial ovaries. Hydrogels form a barrier at the site of injury and have antibacterial, antiadhesive and antistenosis properties for IUA treatment. In this review, we evaluate the physicochemical properties of hydrogels, and focus on the latest applications of hydrogels in POF and IUA. We also found the limitations on clinical application of hydrogel and provide future prospects. Artificial ovary as the future of hydrogel in POF is worth studying, and 3D bioprinting may help the mass production of hydrogels.

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Human umbilical cord mesenchymal stem cells (hUCMSCs) promotes the recovery of ovarian function in a rat model of premature ovarian failure (POF)

Abstract: Human umbilical cord mesenchymal stem cells (hUCMSCs) promotes the recovery of ovarian function in a rat model of premature ovarian failure (POF), Gynecological Endocrinology,

Cited by 16 publications

References 24 publications

Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study

Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study

Therapeutic effect of human umbilical cord mesenchymal stem cells in early traumatic osteonecrosis of the femoral head

Applications of Hydrogels in Premature Ovarian Failure and Intrauterine Adhesion

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