Human umbilical cord mesenchymal stem cell-derived extracellular vesicles harboring IGF-1 improve ovarian function of mice with premature ovarian insufficiency through the Nrf2/HO-1 pathway

Miao, Hui; Miao, Congxiu; Li, Na; Han, Jing

doi:10.1186/s13048-024-01536-8

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2024

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Cited by 2 publications

References 51 publications

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Mangiferin Promotes Porcine Oocyte Maturation and Delays the Postovulatory Aging Process by Up-Regulating Nrf2 Levels

Yuan,

Ji,

Zhang

et al. 2024

Preprint

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Mangiferin Promotes Porcine Oocyte Maturation and Delays the Postovulatory Aging Process by Up-Regulating Nrf2 Levels

Yuan,

Ji,

Zhang

et al. 2024

Preprint

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Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders

Zhang,

Li,

Chen

2024

IJMS

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The global issue of aging populations has become increasingly prominent, thus the research and development for anti-aging therapies to assure longevity as well as to ameliorate age-related complications is put high on the agenda. The young humoral milieu has been substantiated to impart youthful characteristics to aged cells or organs. Extracellular vesicles (EVs) are a heterogeneous group of cell-derived membrane-limited structures that serve as couriers of proteins and genetic material to regulate intercellular communication. Of note, EVs appeared to be an indispensable component of young blood in prolonging lifespans, and circulating EVs have been indicated to mediate the beneficial effect of a young milieu on aging. Human umbilical cord mesenchymal stem cell-derived EVs (HUCMSC-EVs), isolated from the youngest adult stem cell source, are speculated to reproduce the function of circulating EVs in young blood and partially revitalize numerous organs in old animals. Robust evidence has suggested HUCMSC-EVs as muti-target therapeutic agents in combating aging and alleviating age-related degenerative disorders. Here, we provide a comprehensive overview of the anti-aging effects of HUCMSC-EVs in brain, heart, vasculature, kidney, muscle, bone, and other organs. Furthermore, we critically discuss the current investigation on engineering strategies of HUCMSC-EVs, intending to unveil their full potential in the field of anti-aging research.

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Human umbilical cord mesenchymal stem cell-derived extracellular vesicles harboring IGF-1 improve ovarian function of mice with premature ovarian insufficiency through the Nrf2/HO-1 pathway

Cited by 2 publications

References 51 publications

Mangiferin Promotes Porcine Oocyte Maturation and Delays the Postovulatory Aging Process by Up-Regulating Nrf2 Levels

Mangiferin Promotes Porcine Oocyte Maturation and Delays the Postovulatory Aging Process by Up-Regulating Nrf2 Levels

Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders

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