Human umbilical mesenchymal stem cells enhance the expression of neurotrophic factors and protect ataxic mice

Zhang, Mei-Juan; Sun, Jun; Lai, Qi; Liu, Zhuo; Zhang, Zhuo; Cao, Wangsen; Li, Wei; Xu, Yun

doi:10.1016/j.brainres.2011.05.055

Cited by 77 publications

(56 citation statements)

References 38 publications

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“…However, the efficacy of hUC-MSCs on ataxic mice was related to their release of neuronal growth factors, not differentiation into neuronal cells [21]. This study showed that hUC-MSCs exerted immune modulatory effects by inducing a shift of T cells from Th1 proinflammatory cells to Th2 anti-inflammatory cells.…”

Section: Stem Cells Treatment For Eaementioning

confidence: 71%

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Human Umbilical Cord Stem Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Immunoinflammation and Remyelination

Zhang

Lù

et al. 2013

Stem Cells and Development

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Multiple sclerosis (MS) is an irreversible and demyelinating disease of the central nervous system, in part influenced by chronic inflammation. There is no proven effective therapy to stop the pathological progression of MS, although suppressing the immune system to control the inflammatory response may improve the clinical performance acutely. Here, we found that mesenchymal stem cells from human umbilical cord (hUC-MSCs) could restore behavioral functions and attenuate the histopathological deficits of experimental autoimmune encephalomyelitis mice over the long term (i.e., 50 days) by suppression of perivascular immune cell infiltrations and reduction in both demyelination and axonal injury in the spinal cord. These findings suggest that transplantation of hUC-MSCs may be a potential therapy for MS.

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Section: Stem Cells Treatment For Eaementioning

confidence: 71%

“…Our previous study verified that hUC-MSCs can cross the blood-brain barrier via intravenous transplantation [21]. However, the efficacy of hUC-MSCs on ataxic mice was related to their release of neuronal growth factors, not differentiation into neuronal cells [21].…”

Section: Stem Cells Treatment For Eaementioning

confidence: 95%

Human Umbilical Cord Stem Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Immunoinflammation and Remyelination

Zhang

Lù

et al. 2013

Stem Cells and Development

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“…Brain implanted marrow stromal cells also differentiate into glial cells [25] . Importantly, grafting MSCs in several brain lesion models reduces neuronal deficits [35][36][37][38][39][40][41][42] . However, current evidence suggests that in the experimental models used, the repair and functional improvements reported are primarily mediated by paracrine or cell-cell interactions rather than by the successful engraftment and the in situ transdifferentiation of implanted MSCs into neural cells [43][44][45][46][47] .…”

Section: Artifactsmentioning

confidence: 99%

Brain mesenchymal stem cells: The other stem cells of the brain?

Appaix

Nissou

Sanden

et al. 2014

WJSC

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Multipotent mesenchymal stromal cells (MSC), have the potential to differentiate into cells of the mesenchymal lineage and have non-progenitor functions including immunomodulation. The demonstration that MSCs are perivascular cells found in almost all adult tissues raises fascinating perspectives on their role in tissue maintenance and repair. However, some controversies about the physiological role of the perivascular MSCs residing outside the bone marrow and on their therapeutic potential in regenerative medicine exist. In brain, perivascular MSCs like pericytes and adventitial cells, could constitute another stem cell population distinct to the neural stem cell pool. The demonstration of the neuronal potential of MSCs requires stringent criteria including morphological changes, the demonstration of neural biomarkers expression, electrophysiological recordings, and the absence of cell fusion. The recent finding that brain cancer stem cells can transdifferentiate into pericytes is another facet of the plasticity of these cells. It suggests that the perversion of the stem cell potential of pericytes might play an even unsuspected role in cancer formation and tumor progression.

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“…Instead, trophic factors released from MSCs might act on neurons because hepatocyte growth factor (HGF), fibroblast growth factor-2 (FGF-2), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF) have all been detected in MSC-conditioned medium [30]. Indeed, human umbilical MSC-treated mice showed higher levels of IGF-1 and VEGF in the cerebellum and peripheral blood circulation in ataxic mice induced by cytosine beta-D-arabinofuranoside [28]. The extracellular matrix molecules produced by MSCs have also been shown to support neural cell attachment, growth, and axonal extension [36].…”

Section: Actions Of Administered Mscs On Neuronsmentioning

confidence: 96%

“…The first attempt was to use pharmacologically induced ataxic animals. Ataxic mice were induced by cytosine beta-D-arabinofuranoside, after which human umbilical MSCs were injected into these mice [28]. The ataxic mice were given an intravenous injection of 2 × 10 6 human umbilical MSCs once a week for three consecutive weeks.…”

Section: Efficacy Of Mscs In Treating Mouse Models For Cerebellar Ataxiamentioning

confidence: 99%

Mesenchymal Stem Cells as a Potential Therapeutic Tool for Spinocerebellar Ataxia

et al. 2014

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Spinocerebellar ataxia (SCA) is a devastating progressive neurodegenerative disorder, for which no effective treatments have been developed. However, some studies have shown that an intracerebellar or intrathecal injection of mesenchymal stem cells (MSCs) was partially effective in some genetic mouse models of cerebellar ataxia such as SCA1 and Lurcher mutant. MSCs likely exert their therapeutic efficacy by secreting innate factors to induce neuronal growth and synaptic connection and reduce apoptosis. In this review, we introduce the therapeutic influence of MSCs on each mouse model for cerebellar ataxia and the possible mechanisms underlying the action of MSCs. We also introduce studies on the safety and effectiveness of umbilical cord MSCs for patients with SCA.

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Human umbilical mesenchymal stem cells enhance the expression of neurotrophic factors and protect ataxic mice

Cited by 77 publications

References 38 publications

Human Umbilical Cord Stem Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Immunoinflammation and Remyelination

Human Umbilical Cord Stem Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Immunoinflammation and Remyelination

Brain mesenchymal stem cells: The other stem cells of the brain?

Mesenchymal Stem Cells as a Potential Therapeutic Tool for Spinocerebellar Ataxia

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