Human Viral Oncogenesis: A Cancer Hallmarks Analysis

Mesri, Enrique A.; Feitelson, Mark A.; Münger, Karl

doi:10.1016/j.chom.2014.02.011

Cited by 561 publications

(589 citation statements)

References 134 publications

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“…Epstein-Barr virus (EBV) infects more than 90% of the global adult population and contributes to several malignancies including nasopharyngeal carcinoma (NPC), a prevalent cancer in the southern region of China and South-East Asia (23,24). Epigenetic changes induced by EBV are key events in the viral process of carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase

Yan

Liu

et al. 2016

Cancer Research

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Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), a prevalent cancer in China. LSH expression was increased in NPC, where it was controlled by the Epstein-Barr virus-encoded protein LMP1. In NPC cells in vitro and in vivo, LSH promoted cancer progression in part by regulating expression of fumarate hydratase (FH), a core component of the tricarboxylic acid cycle. LSH bound to the FH promoter, recruiting the epigenetic silencer factor G9a to repress FH transcription. Clinically, we found that the concentration of TCA intermediates in NPC patient sera was deregulated in the presence of LSH. RNAi-mediated silencing of FH mimicked LSH overexpression, establishing FH as downstream mediator of LSH effects. The TCA intermediates a-KG and citrate potentiated the malignant character of NPC cells, in part by altering IKKa-dependent EMT gene expression. In this manner, LSH furthered malignant progression of NPC by modifying cancer cell metabolism to support EMT.

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Section: Introductionmentioning

confidence: 99%

Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase

Yan

Liu

et al. 2016

Cancer Research

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“…Examples include, viral proteins specifically associated with virus-induced malignancies (approximately 12% of all cancers), 12 and oncogene and tumor suppressor gene products or their mutant variants. 6 Oncofetal antigens and melanoma associated antigens represent those with restricted expression in non-malignant tissues, 13,14 whereas cancer testis antigens are only expressed, as the name suggests, in the tumor and in testes, with testes being protected by mechanisms of immune privilege.…”

Section: Tumor Antigen Classificationsmentioning

confidence: 99%

Overexpressed oncogenic tumor-self antigens

Bright

Byrne³

2014

Human Vaccines & Immunotherapeutics

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“…How oxidative stress is involved in these various steps is the object of revision and investigation. Furthermore, ROS may augment tumor invasion and metastasis by increasing the rates of cell migration [55,56].…”

Section: Discussionmentioning

confidence: 99%

Multivariate discriminant analysis of redox and progression indexes in Cuban AIDS patients with Kaposis sarcoma

Valle¹,

Duque-Vizcaino²,

Calás-Hechavarria³

et al. 2017

Oxid Antioxid Med Sci

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Objectives: Infection by human immunodeficiency virus (HIV) generates sustained reactive oxygen species production. An increasing number of studies underline the pathogenic impact of high-grade local and systemic oxidative stress in the activation of Herpesvirus 8 producing Kaposi's sarcoma (KS) co-infection in acquired immunodeficiency syndrome (AIDS) patients. This study aimed to determine the redox status in AIDS-KS Cuban individuals and to explore the relation between redox and progression variables. Methods: Blood samples were drawn from 99 individuals divided into three groups (33 each one; age range 30-50 years): AIDS, AIDS-KS, and presumable healthy subjects. Total peroxide, malondialdehyde, and advanced oxidation protein products as damage indexes and antioxidant responses (glutathione, peroxidation potential, superoxide dismutase, and catalase) were determined from the blood samples. Furthermore, hematological and hemochemical indexes, progression indexes (viral load, CD4 + T lymphocyte absolute count), and tumoral progression indexes were assessed. Different statistical analyses were done. Results: Compared to healthy subjects, both groups of AIDS patients had significant differences in global indices of damage and antioxidant status. The comparison between the groups revealed that AIDS-KS group had a significantly higher damage and lower antioxidant status compared to the healthy control and AIDS groups. Multivariate statistical analysis clearly separated groups according progression indexes and redox profile, obtaining two canonical functions. Conclusions: These results corroborate that substantial oxidative stress occurs in AIDS condition and also during KS-HIV co-infection with different molecular extension and interdependence to progression indexes. Redox indexes diagnosis should be considered in early diagnostics, prevention and treatment of KS-HIV coinfection, which would be worthwhile to conduct a more comprehensive study and manage of infection.

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Human Viral Oncogenesis: A Cancer Hallmarks Analysis

Cited by 561 publications

References 134 publications

Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase

Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase

Overexpressed oncogenic tumor-self antigens

Multivariate discriminant analysis of redox and progression indexes in Cuban AIDS patients with Kaposis sarcoma

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