Human α-Lactalbumin and Bovine β-Lactoglobulin Absorption in Premature Infants

Kuitunen, O. O. M.; Savilahti, Erkki; Sarnesto, Annikki

doi:10.1203/00006450-199403000-00014

Cited by 22 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Human ALA and bovine BLG were detected in 19 (45%) and four (10%) of our 42 subjects, respectively. We did not measure protein permeability in healthy controls, but in an earlier study we detected ALA in only one of 20 healthy infants older than 8 months (2,32).…”

Section: Discussionmentioning

confidence: 99%

Gut Permeability to Human α‐Lactalbumin, β‐Lactoglobulin, Mannitol, and Lactulose in Celiac Disease

Kuitunen,

Savilahti

1996

J. pediatr. gastroenterol. nutr.

Self Cite

View full text Add to dashboard Cite

SummaryOur objective was to examine the permeability of the gut to protein macromolecules and sugar probes and their possible association in celiac disease patients. We studied the permeability to human α‐lactalbumin, β‐lactoglobulin, mannitol, and lactulose on 46 occasions in 33 celiac disease patients in various phases of the disease; in addition, mannitol and lactulose permeability was studied in 18 healthy controls. Lactalbumin absorption was detected in 19 of 42 patients tested, more often in celiac disease patients with villous atrophy than in those with normal jejunal biopsy (p = 0.01). Higher absorption of lactalbumin was found in patients with subtotal villous atrophy than in those with normal biopsy (p = 0.02). β‐lactoglobulin was found in four of 42 patients tested. Less mannitol was absorbed by patients with either subtotal or partial villous atrophy than by those with normal histology (p = 0.001 and 0.006, respectively). Lactulose recovery was higher in newly diagnosed patients and patients with subtotal villous atrophy than in controls (p = 0.007 and 0.03, respectively). The lactulose/mannitol ratio was higher in newly diagnosed patients and patients with villous atrophy than in controls (p = 0.002 and 0.002, respectively). The correlation between permeability to lactalbumin and mannitol and lactulose was poor. We conclude that permeability to proteins and sugar molecules is abnormal in celiac disease patients with mucosal damage and that they probably reflect different mechanisms of penetration.

show abstract

Section: Discussionmentioning

confidence: 99%

Gut Permeability to Human α‐Lactalbumin, β‐Lactoglobulin, Mannitol, and Lactulose in Celiac Disease

Kuitunen,

Savilahti

1996

J. pediatr. gastroenterol. nutr.

Self Cite

View full text Add to dashboard Cite

show abstract

“…BLG is relatively pepsin‐resistant throughout the gastric phase and has a fast‐gastric emptying, followed by rapid intestinal hydrolysis ( in vitro and in vivo data) leading to absorption of amino acids in the proximal intestine (Mahé et al, 1995, 1996; Rieu et al, 2007; Farnfield et al, 2009; Sanchón et al, 2018; Mackie et al, 2019). Systemic absorption of undigested BLG may occur in infants, owing to gut transient permeability to BLG when cow's milk‐based formula is started (Kuitunen et al, 1994).…”

Section: Assessmentmentioning

confidence: 99%

Safety of Beta‐lactoglobulin as a Novel food pursuant to Regulation (EU) 2015/2283

Turck¹,

Bohn²,

Castenmiller³

et al. 2022

EFS2

View full text Add to dashboard Cite

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on beta‐lactoglobulin (BLG) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF (≥ 90% w/w dry matter protein) consists of BLG as primary component (≥ 90% of total protein), which is equivalent to BLG present in bovine milk and whey protein isolate (WPI). The NF is produced from bovine whey by crystallisation under acidic or neutral conditions. The NF is proposed to be used as a food ingredient in isotonic and sport drinks, whey powder and milk‐based drinks and similar products, and in food for special medical purposes as defined in Regulation (EU) No 609/2013. The target population is the general population. The highest daily intake of the NF was estimated for children of 3 to < 10 years of age as 667 mg/kg body weight (bw) per day. The NF presents proximate composition and content of essential amino acids similar to those in WPI. The Panel notes that the highest mean and highest 95th percentile daily protein intakes from the NF are below the protein population reference intakes for all population groups. Although a tolerable upper intake level has not been derived for protein, the protein intake from the NF may nevertheless further contribute to an already high dietary protein intake in Europe. The exposure to the reported minerals does not raise concerns. The Panel considers that the consumption of the NF is not nutritionally disadvantageous. No genotoxic concerns were identified from the standard in vitro test battery. No adverse effects were observed in the subchronic toxicity study, up to the highest dose tested, i.e. 1,000 mg NF/kg bw per day. The Panel concludes that the NF is safe under the proposed conditions of use.

show abstract

Association between preterm birth and asthma and atopic dermatitis in preschool children: a nationwide population-based study

Cha,

Hwang,

et al. 2024

Eur J Pediatr

View full text Add to dashboard Cite

Human α-Lactalbumin and Bovine β-Lactoglobulin Absorption in Premature Infants

Cited by 22 publications

References 16 publications

Gut Permeability to Human α‐Lactalbumin, β‐Lactoglobulin, Mannitol, and Lactulose in Celiac Disease

Gut Permeability to Human α‐Lactalbumin, β‐Lactoglobulin, Mannitol, and Lactulose in Celiac Disease

Safety of Beta‐lactoglobulin as a Novel food pursuant to Regulation (EU) 2015/2283

Association between preterm birth and asthma and atopic dermatitis in preschool children: a nationwide population-based study

Contact Info

Product

Resources

About