Human γδ Cells Are Resistant to Induction of Anergy but Not to Induction of Cell Death in Vitro

Approximately 4% of peripheral blood T cells in humans express a T cell receptor with markedly restricted germline gene segment usage (V gamma 2 V delta 2). Remarkably, these T cells expand 2- to 10-fold (8%-60% of all circulating T cells) during many microbial infections. We show here that these T cells recognize a family of naturally occurring primary alkylamines in a TCR-dependent manner. These antigenic alkylamines are secreted to millimolar concentrations in bacterial supernatants and are found in certain edible plants. Given the large numbers of memory V gamma 2 V delta 2 T cells in adult humans, recognition of alkylamine antigens offers the immune system a response of the magnitude of major superantigens for alpha beta T cells and may bridge the gap between innate and adaptive immunity.

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Human γδ T Cells Recognize Alkylamines Derived from Microbes, Edible Plants, and Tea

Bukowski

1999

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Effector functions and control of human γδ T-cell activation

Kabelitz

1999

Microbes and Infection

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Tuberculosis I: a conceptual frame for the immunopathology of the disease

Maes

Causse²,

Maes³

1999

Medical Hypotheses

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Human γδ Cells Are Resistant to Induction of Anergy but Not to Induction of Cell Death in Vitro

Cited by 4 publications

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Human γδ T Cells Recognize Alkylamines Derived from Microbes, Edible Plants, and Tea

Human γδ T Cells Recognize Alkylamines Derived from Microbes, Edible Plants, and Tea

Effector functions and control of human γδ T-cell activation

Tuberculosis I: a conceptual frame for the immunopathology of the disease

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