The interactivist model has explored a number of consequences of process metaphysics. These include reversals of some fundamental metaphysical assumptions dominant since the ancient Greeks, and multiple further consequences throughout the metaphysics of the world, minds, and persons. This article surveys some of these consequences, ranging from issues regarding entities and supervenience to the emergence of normative phenomena such as representation, rationality, persons, and ethics. Contemporary thought is dominated by a particle-based metaphysics that can be traced to at least Parmenides and the responses of Democritus and Empedocles (Graham 2006; cf. Palmer 2010). There are, however, multiple reasons for working within a process metaphysics rather than a substance or particle metaphysics, 1 both in terms of consistency with current science and in terms of the further philosophical and theoretical developments that are thereby enabled. 1 Parmenides argued (against Heraclitus) against change, and Democritus and Empedocles proposed models of apparent change with an unchanging substrate-atoms for Democritus and substances for Empedocles (Graham 2006). It is this underlying assumption of the metaphysical necessity of an unchanging substrate that is crucial to the position in the main text, and I refer to such an assumption as that of a substance metaphysics, for both ''stuffs'' as for Empedocles and ''atoms'' as for Democritus.