Humidifier lung and humidifier fever

Baur, Xaver; Behr, Jürgen; Dewair, Mahmoud; Ehret, W.; Fruhmann, G; Vogelmeier, Claus; Weiss, Walter; Zinkernagel, V.

doi:10.1007/bf02714035

Cited by 52 publications

(34 citation statements)

References 19 publications

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“…In some previous studies, humidifiers have been associated with inhalation lung injury, for example, hypersensitivity pneumonitis 9,10 . And some cases were reported about humidifier-associated diseases like extrinsic allergic alveolitis and toxic aveolitis 11,12 . However, it is not clear that humidifier have been associated with AFOP in this case.…”

Section: Discussionmentioning

confidence: 99%

Severe Acute Fibrinous and Organizing Pneumonia with Acute Respiratory Distress Syndrome

et al. 2011

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Acute fibrinous and organizing pneumonia is a newly recognized pattern of acute lung injury. A 49-year-old female presented with a cough and worsening dyspnea on exertion. She had no history of smoking and no specific past medical history except exposure of home humidifier containing sterilizer. A chest computed tomography scan showed patchy consolidation with fibrosis in the right lower lobe and ill-defined centrilobular ground glass opacity in both lungs. The pathological findings were patchy areas of lung parenchyma with fibrin deposits in the alveolar ducts and alveoli, and fibrin balls with hemosiderin deposition in the alveolar spaces. The histological pattern of our case is differentiated from diffuse alveolar damage by the absence of hyaline membranes, and from eosinophilic pneumonia by the lack of eosinophils. In our case, the patient was treated with corticosteroid pulse therapy. However, the clinical course became aggravated and she died within two weeks.

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Section: Discussionmentioning

confidence: 99%

Severe Acute Fibrinous and Organizing Pneumonia with Acute Respiratory Distress Syndrome

et al. 2011

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“…A. pullulans also causes hypersensitive pneumonitis such as ‘sauna taker’s lung’ [36]. It has been isolated from air conditioning units coincident with antibodies to this organism being found in the blood of patients in Colorado [37], New York [38] and Germany [39]. Although we recognized an increased incidence of asthma evaluations and admissions during times of increased Aureobasidium , identified individuals with skin test reactivity to extracts of A. pullulans , and detected high molecular weight allergens in Aureobasidium extracts using patient sera IgE, direct provocation testing has yet to be accomplished.…”

Section: Discussionmentioning

confidence: 99%

Identification and Possible Disease Mechanisms of an Under-Recognized Fungus, <i>Aureobasidium pullulans</i>

Taylor

Esch²,

Flagan³

et al. 2005

Int Arch Allergy Immunol

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Background: Investigations into the occurrence and health effects of yeast-like fungi in the outdoor air in the US have been limited. We sought to identify a respirable-sized fungus common in the Pasadena air, locate a major source for the emissions and investigate its relevance to allergic disease. Methods: Yeast-like fungi sampled from the environment were isolated, microscopically examined and sequenced. Pasadena allergy patients were skin tested with commercially available fungal extracts. Patient serum was immunoanalyzed for specific IgE reactivity. Nearby vegetation was analyzed in a controlled emission chamber to find a major source for the aerosols. Results: Hyaline unicellular conidia comprised up to 90% (41,250 m^–3 of air) of total fungal counts and generally peaked at night and during periods of rainfall and ensuing winds throughout the fall and winter. Flowers were determined to be a major source of the emissions. The cellular and colonial morphology of isolates were consistent with Aureobasidium species. The sequence of the D1/D2 region of the 26S ribosomal subunit of isolates from flowers showed identity to two strains of Aureobasidium pullulans (black yeast). Seventeen percent (16/94) of atopic individuals had positive skin testing with A. pullulans extract. Patient sera IgE identified several high molecular weight allergens in Aureobasidium extracts. Conclusions: Respirable-sized conidia of A. pullulans are emitted from flowers and form high concentrations in the air. They are associated with immediate reactivity on skin tests, bind to patient sera IgE, and might be relevant in allergic upper and lower airway diseases.

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“…In other countries, thermophilic actinomycetes (5) and pyrethrum (6) (7), cheese worker's lung (8,9), and farmer's lung (10). Here, we report a case of MWL induced by spores of Penicillium citrinum.…”

Section: Hypersensitivity Pneumonitis (Hp) Is An Allergic Immunoreactmentioning

confidence: 99%

Hypersensitivity Pneumonitis Induced by Spores of Penicillium citrinum in a Worker Cultivating Enoki Mushroom

et al. 2006

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Humidifier lung and humidifier fever

Cited by 52 publications

References 19 publications

Severe Acute Fibrinous and Organizing Pneumonia with Acute Respiratory Distress Syndrome

Severe Acute Fibrinous and Organizing Pneumonia with Acute Respiratory Distress Syndrome

Identification and Possible Disease Mechanisms of an Under-Recognized Fungus, <i>Aureobasidium pullulans</i>

Hypersensitivity Pneumonitis Induced by Spores of Penicillium citrinum in a Worker Cultivating Enoki Mushroom

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