Humoral and Cell-Mediated Immunity to Histoplasma Capsulatum during Experimental Infection in Neotropical Bats (Artibeus Lituratus) *

McMurray, David N.; Thomas, Maurice E.; Greer, Donald L.; Tolentino, Narda L.

doi:10.4269/ajtmh.1978.27.815

Cited by 12 publications

(5 citation statements)

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“…These experiments followed the design of those reported for experimental infections in bats with H. capsulatum [22,23]. The frugivorous bats, A. lituratus, were captured at night in mist nets near Cali, Colombia and maintained on a special high protein-vitamin diet as previously described [27].…”

Section: Methodsmentioning

confidence: 99%

“…At weekly intervals after infection all bats were anesthetized lightly with ether and bled by cardiac puncture [22]. Approximately 0.3 ml of blood was taken from each bat, allowed to clot, and the serum separated.…”

Section: Serology and Footpad Testsmentioning

confidence: 99%

“…Because the immune response to P. brasiliensis in the chiroptera is entirely unknown, the development of humoral and cell-mediated immunity to this agent was also studied. Our success in using A. lituratus as an animal model for studies of the pathogenesis and immune response to H. capsulatum [22,23] stimulated these studies with P. brasiliensis.…”

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confidence: 97%

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Pathogenesis and immune response toParacoccidioides brasiliensisin the fructivorous bat,Artibeus lituratus

Greer¹,

McMurray²

1981

Med Mycol

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Section: Methodsmentioning

confidence: 99%

Section: Serology and Footpad Testsmentioning

confidence: 99%

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Pathogenesis and immune response toParacoccidioides brasiliensisin the fructivorous bat,Artibeus lituratus

Greer¹,

McMurray²

1981

Med Mycol

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“…Other fungi recovered are as follows: Paracoccidioides brasiliensis (12), Cryptococcus neoformans (11), Cryptococcus diffluens, Cryptococcus albidus, Cryptococcus laurentii, Candida parapsilosis, Torulopsis glabrata (6), and Wangiella dermatitidis (26) from the internal organs of bats; Sporothrix schenckii from the feces, and Trichophyton mentagrophytes and Microsporum canis from the fur (10). Natural susceptibility of bats to fungal infection has been further demonstrated in experimental histoplasmosis (5,21,22,34), coccidioidomycosis (17), and paracoccidioidomycosis (9). The role of bats as a natural habitat and a potential source of dissemination for Histoplasma capsulatum has been established (5,16,29).…”

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confidence: 99%

Isolation of fungi from bats of the Amazon basin

Mok¹,

Luizão²,

Silva³

1982

Appl Environ Microbiol

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A total of 2,886 bats captured in the Amazon Basin of Brazil were processed for the isolation of fungi. From the livers, spleens, and lungs of 155 bats (5.4%), 186 fungal isolates of the genera Candida (123 isolates), Trichosporon (26 isolates), Torulopsis (25 isolates), Kluyveromyces (11 isolates), and Geotrichum (1 isolate) were recovered. Seven known pathogenic species were present: Candida parapsilosis, C. guilliermondii, C. albicans, C. stellatoidea, C. pseudotropicalis, Trichosporon beigelii, and Torulopsis glabrata. Twenty-three culture-positive bats showed identical fungal colonization in multiple organs or mixed colonization in a single organ. The fungal isolation rates for individual bat species varied from 1 fungus per 87 bats to 3 fungi per 13 bats, and the mycoflora diversity for members of an individual fungus-bearing bat species varied from 16 fungi per 40 bats to 7 fungi per 6 bats. Of the 38 fungal species isolated, 36 had not been previously described as in vivo bat isolates. Of the 27 culture-positive bat species, 21 had not been previously described as mammalian hosts for medically or nonmedically important fungi.

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“…So Tadarida brasiliensis had an 80% mortality whereas Artibeus lituratus and Pteronotus suapurensis were infectable, but without any mortality. 18 Experimental intranasal infection of the lungs of A. lituratus was possible with fewer than 100 viable spores, 49 and led to disseminated infection, antibody production, and temporary cutaneous delayed hypersensitivity. Subsequently yeasts were shed via the intestinal villi into the faeces.…”

Section: Resultsmentioning

confidence: 99%

Infection of bats with Histoplasma species

Gugnani

Denning

2023

Medical Mycology

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Histoplasma species infect humans and animals, notably bats. Histoplasma species are thermally dimorphic fungi existing in mycelial form in the natural environment and in yeast form in infected tissues. In this narrative literature review, we summarize the occurrence of Histoplasma spp. in different species of bat tissues (n = 49) and in soil admixed with bat guano where the species of bat dwelling nearby has been identified (an additional 18 species likely infected) to provide an up-to-date summary of data. Most positive isolations are from the Americas and Caribbean, with some studies from Thailand, Malaysia, Nigeria, Slovenia, France and Australia. We also summarise some of the early experimental work to elucidate pathogenicity, latency, immune response and faecal excretion in bats. Given the recent recognition of the global extent of histoplasmosis, thermal dimorphism in Histoplasma spp. and global heating, additional work on understanding the complex relationship between Histoplasma and bats is desirable.

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Humoral and Cell-Mediated Immunity to Histoplasma Capsulatum during Experimental Infection in Neotropical Bats (Artibeus Lituratus) *

Cited by 12 publications

References 0 publications

Pathogenesis and immune response toParacoccidioides brasiliensisin the fructivorous bat,Artibeus lituratus

Pathogenesis and immune response toParacoccidioides brasiliensisin the fructivorous bat,Artibeus lituratus

Isolation of fungi from bats of the Amazon basin

Infection of bats with Histoplasma species

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