Humoral and cellular immune memory response 12 years following single dose vaccination against hepatitis A in Argentinian children

Urueña, Analía; Badano, María Noel; Baré, Patricia; González, Jorge; Vicentín, Rosalía; Calli, A.R.; Cañero-Velasco, María Cristina; Fink, S.; Vizzotti, Carla

doi:10.1016/j.vaccine.2021.11.037

Cited by 15 publications

(9 citation statements)

References 34 publications

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“…In general, the evaluation of vaccine response is conducted through antibody analysis. The present study was also important as it tested the cellular immune response among those without detectable antibodies, which is generally poorly evaluated in other series, with some exceptions 13,15–18 . Thus, the sensitivity to detect immune memory was increased, with a greater number of children with evidence of an anti‐HAV immunity being observed.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the sensitivity to detect immune memory was increased, with a greater number of children with evidence of an anti‐HAV immunity being observed. It has already been described that the inactivated HAV vaccine induces an adequate proliferative response of memory T cells 13,15–18 . The formalin‐inactivated virus, used as a vaccine, activates CD4 + and CD8 + T lymphocytes, also inducing the production of interferon‐gamma (IFN‐y) by peripheral blood mononuclear cells, starting with the first dose of the vaccine 15,16 .…”

Section: Discussionmentioning

confidence: 99%

“…it tested the cellular immune response among those without detectable antibodies, which is generally poorly evaluated in other series, with some exceptions. 13,[15][16][17][18] Thus, the sensitivity to detect immune memory was increased, with a greater number of children with evidence of an anti-HAV immunity being observed. It has already been described that the inactivated HAV vaccine induces an adequate proliferative response of memory T cells.…”

Section: F I G U R E 1 Comparison Of Interferongamma (Ifn-y) Producti...mentioning

confidence: 99%

“…It has already been described that the inactivated HAV vaccine induces an adequate proliferative response of memory T cells. 13,[15][16][17][18] The formalin-inactivated virus, used as a vaccine, activates CD4 + and CD8 + T lymphocytes, also inducing the production of interferon-gamma (IFN-y) by peripheral blood mononuclear cells, starting with the first dose of the vaccine. 15,16 Melgaço et al, 13 while investigating the profile of memory T cells in adults vaccinated with only one dose of the inactivated virus vaccine against HAV, identified significant indices in the levels of IFN-y, interleukin 6 and Tumour Necrosis Factor (TNF), observing the clonal expansion of T cells specific against HAV regardless of the identification of protective levels of anti-HAV antibodies.…”

Section: F I G U R E 1 Comparison Of Interferongamma (Ifn-y) Producti...mentioning

confidence: 99%

“…It was not possible to analyse in the present study the subpopulations of T lymphocytes or other specific interleukins against HAV, as done by other authors. 13,17,18 Instead, stimulation of IFN-y production by challenge with HAV VP1 antigen was evaluated, 14 by Elispot, was evaluated, which is one of the main methods for studying the cellular response to vaccines. Among the PBMC samples, out of the 67 children tested, the production of IFN-y was not identified in 65.7%.…”

Section: F I G U R E 1 Comparison Of Interferongamma (Ifn-y) Producti...mentioning

confidence: 99%

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Persistence of immunity against hepatitis A in Brazilian children vaccinated with a single dose of inactivated virus vaccine

Brito

Oliveira²,

Silva

et al. 2023

Journal of Viral Hepatitis

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In 2014, the Brazilian National Immunization Program implemented the universal vaccination against the hepatitis A virus (HAV) for children aged 12 months and older, applying a single dose of the inactivated virus vaccine. It is essential to carry out follow‐up studies in this population, aiming to verify the longevity of HAV immunological memory. This study evaluated the humoral and cellular immune response of a cohort of children vaccinated between 2014 and 2015, and further investigated between 2015 and 2016, and who had their initial antibody response assessed after the single dose. A second evaluation took place in January 2022. We examined 109 children out of the 252 that took part in the initial cohort. Seventy (64.2%) of them had anti‐HAV IgG antibodies. Cellular immune response assays were performed in 37 anti‐HAV‐negative and 30 anti‐HAV‐positive children. Production of interferon‐gamma (IFN‐y) stimulated with the VP1 antigen was demonstrated in 34.3% of these 67 samples. Of the 37 negative anti‐HAV samples, 12 (32.4%) produced IFN‐y. Among the 30 anti‐HAV‐positive, 11 (36.7%) produced IFN‐y. In total, 82 (76.6%) children presented some type of immune response against HAV. These findings demonstrate the persistence of immunological memory against HAV in the majority of children vaccinated between 6 and 7 years with a single dose of the inactivated virus vaccine.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: F I G U R E 1 Comparison Of Interferongamma (Ifn-y) Producti...mentioning

confidence: 99%

Section: F I G U R E 1 Comparison Of Interferongamma (Ifn-y) Producti...mentioning

confidence: 99%

Section: F I G U R E 1 Comparison Of Interferongamma (Ifn-y) Producti...mentioning

confidence: 99%

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Persistence of immunity against hepatitis A in Brazilian children vaccinated with a single dose of inactivated virus vaccine

Brito

Oliveira²,

Silva

et al. 2023

Journal of Viral Hepatitis

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Hepatitis A in Latin America: The current scenario

Ré,

Ridruejo,

Fantilli

et al. 2024

Reviews in Medical Virology

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This review aims to gather and disseminate updated information regarding hepatitis A virus (HAV) in Latin America (LA) in the last 11 years, including seroprevalence, post‐vaccination studies, virus detection in aqueous matrices and food samples, and outbreak reports. Only 24 seroprevalence studies were published between 2012 and 2023 with 55%–100% reported prevalences of anti‐HAV IgG. Among the 25 LA countries, only eight of them have introduced HAV vaccines into their immunisation programs. Outbreaks of hepatitis A occurred between 2017–2019, mainly affecting men who have sex with men in Argentina, Brazil and Chile, probably as a consequence of the abrupt decline of young adults' immunity. This could be due to that young adult have never been infected in childhood (due to socio‐health improvements) and are above the cut‐off ages to be included when the vaccination programs were introduced. Although scarce, studies focused on environmental and food HAV surveillance have shown viral presence in these samples. Surface waters presented HAV detections between 1.2% and 86.7%, and untreated wastewaters between 2.8% and 70.9%. Genotypes found in all cases were IA and IC. The only wastewater‐based epidemiology study showed to be a useful tool as a complement of traditional epidemiological surveillance. Only four LA countries have looked for HAV in food samples, with genome detection rates between 9% and 33%. Latin American HAV circulation scenario is changing. In countries where socioeconomic and sanitary conditions have not improved, the virus persists with high endemicity and the access to the vaccine should be re‐evaluated by local governments. In countries where access to clean water, better sanitary conditions and HAV immunisation programs have been implemented, the number of cases among young adults seems to be increasing, alerting health authorities.

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Pathogen–Host Interaction and Its Associated Molecular Mechanism in HFMD Pathology and Immunology

Li,

Zhang,

Liao

2024

Molecular Biology of Hand-Foot-Mouth Diseases

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Humoral and cellular immune memory response 12 years following single dose vaccination against hepatitis A in Argentinian children

Cited by 15 publications

References 34 publications

Persistence of immunity against hepatitis A in Brazilian children vaccinated with a single dose of inactivated virus vaccine

Persistence of immunity against hepatitis A in Brazilian children vaccinated with a single dose of inactivated virus vaccine

Hepatitis A in Latin America: The current scenario

Pathogen–Host Interaction and Its Associated Molecular Mechanism in HFMD Pathology and Immunology

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