1997
DOI: 10.1007/s004360050319
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Humoral and cellular immune responses to experimental Fasciola hepatica infections in goats

Abstract: Humoral and cellular immune responses to Fasciola hepatica excretory-secretory products (ESPs) in primary and secondary experimental infections in goats were studied. Primary infection induced the development of chronic subclinical fascioliasis that did not affect the establishment of flukes coming from the secondary infection, as the same percentages of recovered flukes were found in both groups. The specific IgG response to F. hepatica ESPs was similar in primary and secondary infections; challenge flukes di… Show more

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Cited by 26 publications
(9 citation statements)
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“…In the present paper, implantation rates (46% and 50.9%) in the infected control and immunized group, respectively, were higher than reported in previous studies in goats (Martínez-Moreno et al 1997, Zafra et al 2008. However, in some experimental infections, implantation rates varying between 42-51% have been reported in sheep (Almazán et al 2001, Ramajo et al 2001.…”
Section: Discussioncontrasting
confidence: 72%
“…In the present paper, implantation rates (46% and 50.9%) in the infected control and immunized group, respectively, were higher than reported in previous studies in goats (Martínez-Moreno et al 1997, Zafra et al 2008. However, in some experimental infections, implantation rates varying between 42-51% have been reported in sheep (Almazán et al 2001, Ramajo et al 2001.…”
Section: Discussioncontrasting
confidence: 72%
“…This strong humoral response has been previously reported in the HLN of sheep [4,6,16] and goats [22,23] chronically infected with F. hepatica, and correlates with the high levels of serum IgG that have also been found in sheep [4,27] and goats [14,15].…”
Section: Discussionmentioning
confidence: 62%
“…E/S antigens in faeces of experimentally infected sheep could be detected from 4 wpi, with sensitivity of 93.3% [ 26 ]. Fluke E/S products recognized by antibodies in sera of infected goats can be detected from 2 wpi [ 27 , 28 ]. The sensitivity and specificity values reported in the literature to detect anti- F. hepatica serum antibodies in sheep ranged from 68.2 to 100% and from 95 to 100%, respectively [ 29 , 30 ].…”
Section: Discussionmentioning
confidence: 99%