Humoral Antibody Production Following Primary and Secondary immunization in Rabbits Treated with Thiamphenicol and Chloramphenicol

Abstract

The primary immune response consisting of humoral antibody production to sheep red blood cells and Proteus X₁₉O antigen injected intravenously was considerably inhibited in rabbits by a thiamphenicol (TAPH) treatment (i.m., 100 mg/kg daily for 12 days) initiated 8 h before the antigen injection. A similar course of chloramphenicol (CAPH) treatment had no immunosuppressive effect, due probably to the higher inactivation rate of CAPH in the rabbit. The immunosuppressive effect of TAPH lasted only as long as the treatment period. Antibody titers in TAPH-treated animals increased to lower values, with respect to controls during this period, after which, instead, the rate of antibody production in the treated rabbits became higher than in the controls, so that 48 h after the last TAPH injection no significant differences between the titers of the two groups were noted any more. The secondary immune response to the same antigens was not influenced, neither in the rabbits treated with TAPH during the primary response, nor in others which received CAPH during the primary immunization and were treated with TAPH during the secondary immunization. Discussing these findings in connection with literature data, it is concluded that TAPH inhibits the immune response by impeding the proliferation of the antigen-stimulated cells rather than by impairing the actual process of immunoglobulin synthesis.

A Convenient Synthesis of Sulfones via Light Promoted Coupling of Sodium Sulfinates and Aryl Halides

“…Due to their unique chemical, biological and pharmaceutical activities, sulfone groups are prevalently present in many bioactive compounds, such as antibiotics thiamphenicol and dapsone, antipsychotics amisulprode (Figure ), agrochemicals and functional materials . These compounds also have great synthetic potentials in Julia olefination, Ramberg‐Backlund reaction and Smiles rearrangement for the preparation of organic building blocks, biologically and pharmaceutically active molecules.…”