Humoral Immune Response Before and After Surgical Therapy in Patients With Odontogenic Inflammatory Cysts

Abstract

Odontogenic inflammatory cysts are pathological lesions that are often represented in clinical practice and they presented potential focal points with an impact on other organs and systems in the bodyThe aim of this research is to compare the patients' humoral immune response by verifying the level of immunoglobulins IgA, IgG and IgM in the serum before and one month after surgical therapy in patients with odontogenic inflammatory cysts.44 male and female patients were undergone surgical enucleation of the cysts in toto -Cystectomio (Partch II). The biopsy material was sent at the Institute of Pathological Anatomy-Skopje for histopathological verification. Patients diagnosed with odontogenic inflammatory cysts were divided into three groups. Тhe values of IgA, IgM and IgG in serum werе examined before and one month after the surgical therapy in Cobas 6000 model c501 (Roche, Germany).The level of IgA did not indicate a significant difference for p=0.2716 vs. p=0.2898. A significant difference, was also not found in terms of the IgG level for p=0.2692 vs. p=0.3614. The comparison of the three groups of patients regarding the level of IgM in serum indicated a significantly higher value of this parameter before the intervention (p=0.0067) and 1 month after the intervention (p=0.0263).The surgical removal generate a decrease in the levels of immunoglobulins' level. These findings suggest that IgA, IgG and IgM may play an important role in the occurrence, development and persistence of cystic lesions.