Humoral immune response to selective mycobacterial antigens and serodiagnosis of active tuberculosis in Bangladeshi patients

Abstract

Background and objective: Serological test has become an important tool in the diagnosis of TB cases. This study focused on the analysis and comparison of antibody response to two Mycobacterium tuberculosis (MTB) antigens namely Ag85 complex and culture filtrate protein (CFP) in patients with tuberculosis. Antibody response to specific antigen was utilized as a diagnostic tool to detect active tuberculosis (TB) cases.

Tuberculosis – burden and serodiagnosis

“…It appeared that IgM and IgG antibody response to Ag85 complex was better compared to that of CFP. Therefore, determination of IgM and IgG against Ag85 complex could be used as a serological marker for diagnosis of active tuberculosis in cases where other tests do not give conclusive information [27]. It is particularly applicable in children where they are unable to provide sputum samples for either staining or culture.…”