Humoral Immunoreactivity in Chronic Active Hepatitis: Relation to HLA Antigens

Lindberg, Johan; Kaijser, B; Lindholm, Annika; Hermodsson, Svante; Iwarson, Sten

doi:10.1159/000232175

Cited by 6 publications

(2 citation statements)

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“…Six patients with CAH had the cholestatic form of the disease and showed a poor response to the ordinary corticosteriod dose. These patients seemed to have more anti-MFs of IgM class (36) when compared to other patients with CAH (%a). Four anti-MF-positive sera were also tested using cells not subjected to drug treatment.…”

Section: Anti-mfsmentioning

confidence: 74%

Cytoskeleton Antibodies in Chronic Active Hepatitis, Primary Biliary Cirrhosis, and Alcoholic Liver Disease

et al. 1983

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Antibodies to cytoplasmic microfilaments, intermediate filaments (vimentin filaments), and microtubules which comprise the cytoskeleton of the cell were assayed in sera from 23 patients with HBsAg‐negative chronic active hepatitis and 1 with HBsAg‐positive chronic active hepatitis, 15 patients with primary biliary cirrhosis, 20 patients with alcoholic liver disease, and 32 healthy controls. The cytoskeleton antibodies were assayed by indirect immunofluorescence technique using vinblastine‐treated cultured human embryonic fibroblasts as substrates. There was a significantly increased incidence of cytoskeleton antibodies in patients with liver disease as compared to the control group. Antibodies to microfilaments were found frequently in sera from patients with chronic active hepatitis (67%) and primary biliary cirrhosis (53%) but were rare in sera from patients with alcoholic liver disease (25%) and in control sera (3%). On the other hand, antibodies to microtubules were found in 50% of sera from patients with alcoholic liver disease but in only 7 to 13% of sera from other groups. Intermediate filament antibodies of IgG or IgA class were found only in patient sera whereas intermediate filament antibodies of IgM class were found in the majority of sera in all groups including control sera. The highest titers of intermediate filament antibodies were seen in primary biliary cirrhosis and chronic active hepatitis. The production of cytoskeleton antibodies may be due to the reorganization or destruction of cytoskeletal structures in the liver.

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Section: Anti-mfsmentioning

confidence: 74%

Cytoskeleton Antibodies in Chronic Active Hepatitis, Primary Biliary Cirrhosis, and Alcoholic Liver Disease

et al. 1983

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“…Furthermore, because of the increased frequency of HLA-B8, which had been reported in populations of patients with hepatitis B-negative CAH (13), they postulated that this histocompatibility antigen might serve as a marker for a specific defect in suppressor T-cell function, although there was no good evidence in man that genes on Chromosome 6 controlling immune regulation were linked to genes coded in the HLA locus. Galbraith et al (14) reported increased levels of anti-bodies to rubella, measles, nuclei, and smooth muscle in patients with CAH with HLA B8 or B12, but these results were not confirmed by Lindberg et al (15,16). Since that time, alterations in immunoregulatory T-cell activity have been demonstrated in CAH (2-6) and there has been confirmation of the increased frequency of HLA-B8.…”

Section: Resultsmentioning

confidence: 97%

Immune regulation and HLA types in chronic hepatitis

Krawitt¹,

Albertini²,

Webb³

et al. 1981

Hepatology

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Studies were undertaken in 32 patients with hepatitis B-negative or -positive chronic active hepatitis or chronic persistent hepatitis to define the relationship between immunoregulatory activity and the HLA-B8 and B12 phenotypes. Suppressor T-cell activity measured by a concanavalin A-induced suppressor system using allogeneic responder cells was dependent on which individual was selected as a source of responder cells. No differences were noted using isogeneic cells as responders. Suppressor T-cell activity measured by the effect of a noninduced suppressor cell on a mixed leukocyte culture was not different from controls. Increased prostaglandin-producing suppressor cell activity was found in patients with hepatitis B-negative (p less than 0.005) and hepatitis B-positive (p less than 0.05) chronic active activity hepatitis. When results of the suppressor activities were compared among patients with chronic hepatitis dependent on the presence of HLA-B8, B12, or neither of these phenotypes, no significant differences were present. These results provide further evidence of altered immunoregulatory function in patients with chronic active hepatitis, which may reflect increased suppression by a population of prostaglandin-producing suppressor cells. The results do not, however, suggest that a gene coding for altered immune regulation is linked to HLA-B8 or B12.

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