Humoral immunotoxicity of polychlorinated diphenyl ethers, phenoxyphenols, dioxins and furans present as contaminants of technical grade pentachlorophenol

Kerkvliet, Nancy I.; Brauner, Julie A.; Matlock, J.P.

doi:10.1016/0300-483x(85)90033-2

Cited by 68 publications

(26 citation statements)

References 27 publications

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“…Two lines of evidence support this conclusion: comparative studies using PCDD, PCDF, and PCB congeners show that potency to cause immune suppression correlates with the binding affinity for the AhR (25)(26)(27)(28)(29); and studies using mice with a defined Ah genotype show that mice with high affinity AhR (e.g., Ahbb C57BI/6 mice) are more sensitive to immune suppression by these compounds than mice with lower affinity AhR (e.g., Ahdd DBA/2 mice or Ahdd congenic C57BI/6 mice) (8,25,26,29). AhR-dependent responses include suppression of the T-cell-dependent antibody response to SRBC (8,(25)(26)(27)(28)30,31), suppression of the T-cell-independent antibody response to trinitrophenyl-lipopolysaccharide (8), suppression of the cytotoxic T lymphocyte (CTL) response to allogeneic tumor cells (29,32) bone marrow toxicity (33), and suppression of the cytotoxic responses of activated neutrophils (34 however, the specific cellular defects induced by TCDD have not been fully elucidated despite considerable research. One of the problems has been a difficulty in demonstrating direct effects of TCDD on in vitro responses of lymphoid cells (35,36).…”

Section: Immunotoxicity Studies Laboratory Animal Studiesmentioning

confidence: 61%

Immunological Effects of Chlorinated Dibenzo-p-Dioxins

Kerkvliet¹

1995

Environmental Health Perspectives

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Section: Immunotoxicity Studies Laboratory Animal Studiesmentioning

confidence: 61%

Immunological Effects of Chlorinated Dibenzo-p-Dioxins

Kerkvliet¹

1995

Environmental Health Perspectives

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“…It was concluded that T-cells, NK cells, and macrophages were relatively resistant to T-PCP, in contrast to the marked sensitivity of elements of the humoral immune response. Several contaminant fractions and purified isomers from T-PCP were analyzed for their humoral immunosuppressive effect (Kerkvliet et al, 1985b). The 1,2,3,6,7,1,2,3,4,6,7,and 1,2,3,4,6,7, this and other evidence was presented for the role of toxic Ah-interactive dioxin and furan contaminants in T-PCP mediated immunotoxicity.…”

Section: ~0 260mentioning

confidence: 97%

“…It is a well-known uncoupler of mitochondrial oxidative phosphorylation and modulator of cytochrome P-450 (Arrhenius et al, 1977), which produces numerous physiological 255 effects including immunotoxicity. Analytical grade (pure) PCP (A-PCP) is reported to have little immunotoxicity in laboratory rodents, whereas technical grade PCP (T-PCP) shows immunosuppressive activity, probably due to the presence of contaminants such as 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin (HCDD) (Holsapple et al, 1984(Holsapple et al, , 1987Kerkvliet et al, 1985b).However, exposure of the mollusc Mercenaria to analytical grade PCP produced an impairment in the ability of the phagocytic hemocytes to destroy bacteria in vivo or in vitro (Anderson et al, 1981;Anderson, 1988). In the current study with medaka, the effects of both A-PCP and T-PCP on phagocyte-mediated CL are considered.…”

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confidence: 99%

Compendium of the FY1990 and FY1992 Research Reviews for the Research Methods Branch

Gardner¹

1994

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Public reporting burden for this collection of information is estimated to average I hour per response, including the time for reviewing Instructions, searching existing data sources. gathering and maintaining the data needed, and completing and reviewing the collection of information Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate Approved for public release; distribution unlimited ABSTRACT (Maximum 200 words)Since 1983, the U.S. Army Biomedical Research and Development Laboratory (USABRDL) has conducted a research program focused on the development of new methods for assessing the potential hazards resulting from exposure to chemicals in the workplace or the environment. This research has been conducted both in-house and extramurally and has involved scientists from other Federal agencies, academic institutions, and the private sector. The need to enhance the integration of the research became increasingly evident as the program grew in the late 1980's. This growth came principally as a result of the U.S. Army Corps of Engineers sponsorship of research to develop environmental applications of new, in vivo hazard assessment models for use in the burgeoning Department of Defense environmental remediation program. One of the many uses of these models is to answer the question, "How clean is clean?" and to assist in the establishment of more realistic clean-up goals for hazardous waste sites.An annual research review meeting was undertaken to facilitate the integration and technology transfer of this research program. This publication is the second 14. SUBJECT TERMS Fish, Medaka, Irout, #13.(Continuation) compendium of these meetings.The papers contained in this document are meant to provide the program management staff with an additional means of reviewing the status and progress of extramural and selected in-house studies in the area of new toxicity assessment models. The papers are, therefore, the principal investigators' (PIs') best efforts to characterize the research at the time of the meeting.Some papers cover the results of several years of research and others outline only the planned research of a new project. The data presented and conclusions of the authors represent the best professional judgment of the respective PI at the time of the workshop but are not equivalent to a peer-reviewed report of completed research. NOTICE DisclaimersThe views, opinions, and/or findings contained in this report are those of the author(s) and should not be construed as official Department of the Army position, policy, or decision, unless so designated by official documentation.Citations of commercial organizations or trade names in this paper do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations.Research was conducted in compliance with the Animal Welfare Act, and other Federal statutes and regulati...

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“…Nevertheless, prenatal effects on the thymus and/or T-cell-mediated immunity may be critical. The immunotoxic effects of TCDD have been shown to be mediated by binding to the Ah receptor, based on structure/activity studies and use of mice genetically different in their responsiveness to TCDD (6)(7)(8)(9). The cellular targets of TCDD appear to be multiple, as suggested by the different assays and end points that have been assessed.…”

Section: Introductionmentioning

confidence: 99%

Workshop on perinatal exposure to dioxin-like compounds. V. Immunologic effects.

Birnbaum

1995

Environ Health Perspect

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The immune system comprises a highly integrated network of multiple tissues and cell types with complicated interactions and effects. It is modulated by the endocrine and nervous systems and there is growing realization of its multifunctionality. The session focusing on immunologic effects of dioxin and related compounds following prenatal exposure involved a review of the immunotoxic effects that have been reported for polyhalogenated aromatic hydrocarbons (PHAHs), a discussion of species differences in responses, and development of the immune system, and data from two ongoing epidemiological studies comparing the immune status of children exposed to higher-than-average concentrations of PHAHs both prenatally and lactationally. -Environ Health Perspect 103(Suppl 2): 157-160 (1995)

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Humoral immunotoxicity of polychlorinated diphenyl ethers, phenoxyphenols, dioxins and furans present as contaminants of technical grade pentachlorophenol

Cited by 68 publications

References 27 publications

Immunological Effects of Chlorinated Dibenzo-p-Dioxins

Immunological Effects of Chlorinated Dibenzo-p-Dioxins

Compendium of the FY1990 and FY1992 Research Reviews for the Research Methods Branch

Workshop on perinatal exposure to dioxin-like compounds. V. Immunologic effects.

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