Humoral innate immune response and disease

Shishido, Stephanie N.; Varahan, Sriram; Yuan, Kai; Li, Xiangdong; Fleming, Sherry D.

doi:10.1016/j.clim.2012.06.002

Cited by 80 publications

(74 citation statements)

References 202 publications

(204 reference statements)

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“…NOD mice have been shown to have elevated macrophage and granulocytes levels (41), which implicates one or both as a potential preventive agent. In addition, the fact that intrastrain superinfection was prevented in 3 out of 4 NOD mice by SCID mouse-derived immune sera indicates that relevant factors in these sera likely are nonantibody components of the humoral innate immune response (65). The failure of this passive transfer to block superinfection by homologous B. burgdorferi in all four mice could be attributed to an inadequate (suboptimal) amount of immune sera being used.…”

Section: Discussionmentioning

confidence: 98%

Bacterial Heterogeneity Is a Requirement for Host Superinfection by the Lyme Disease Spirochete

Rogovskyy

Bankhead

2014

Infect Immun

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In nature, mixed Borrelia burgdorferi infections are common and possibly can be acquired by either superinfection or coinfection. Superinfection by heterologous B. burgdorferi strains has been established experimentally, although the ability of homologous B. burgdorferi clones to superinfect a host has not been studied in detail. Information regarding any potential immune barriers to secondary infection also currently is unavailable. In the present study, the ability to superinfect various mouse models by homologous wild-type clones was examined and compared to superinfection by heterologous strains. To assess the ability of homologous B. burgdorferi clones to successfully superinfect a mouse host, primary-and secondary-infecting spirochetes were recovered via in vitro cultivation of collected blood or tissue samples. This was accomplished by generating two different antibiotic-resistant versions of the wild-type B31-A3 clone in order to distinguish superinfecting B. burgdorferi from primary-infecting spirochetes. The data demonstrate an inability of homologous B. burgdorferi to superinfect immunocompetent mice as opposed to heterologous strains. Attempts to superinfect different types of immunodeficient mice with homologous B. burgdorferi indicate that the murine innate immune system represents a major barrier to intrastrain superinfection. Consequently, the possibility of innate immunity as a driving force for B. burgdorferi heterogeneity during the enzootic cycle is discussed.

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Section: Discussionmentioning

confidence: 98%

Bacterial Heterogeneity Is a Requirement for Host Superinfection by the Lyme Disease Spirochete

Rogovskyy

Bankhead

2014

Infect Immun

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“…The humoral innate immune system is comprised of soluble plasma components that include, but are not exclusive to, complement, natural antibodies, acute phase proteins, and antimicrobial peptides as well as proteins/peptides involved in the contact system (Shishido et al, 2012). These innate molecules play a role in prevention and control of disease which 'complements' cellular innate immunity.…”

Section: Humoral Innate Responsementioning

confidence: 99%

The porcine innate immune system: An update

Mair

Sedlak

Käser

et al. 2014

Developmental & Comparative Immunology

210

157

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Over the last few years, we have seen an increasing interest and demand for pigs in biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of their anatomy, genetics, and physiology, and often are the model of choice for the assessment of novel vaccines and therapeutics in a preclinical stage. However, the pig as a model has much more to offer, and can serve as a model for many biomedical applications including aging research, medical imaging, and pharmaceutical studies to name a few. In this review, we will provide an overview of the innate immune system in pigs, describe its anatomical and physiological key features, and discuss the key players involved. In particular, we compare the porcine innate immune system to that of humans, and emphasize on the importance of the pig as model for human disease.

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“…This heat-shock protein localizes to the lumen of the reticulum under physiological conditions, but translocates to the surface of myeloma cells [166]. SAM-6 NAb also induce lipoptosis, an excess lipid accumulation in cancer cells but not in normal cells, that leads to cell death [167, 168] and reviewed in [169]. However, the role of IgM NAb in tumorigenesis is not always clear.…”

Section: The Role Of Natural Antibodies In Diseasementioning

confidence: 99%

Evasion and interactions of the humoral innate immune response in pathogen invasion, autoimmune disease, and cancer

Rettig

Harbin

Harrington

et al. 2015

Clinical Immunology

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The humoral innate immune system is composed of three major branches, complement, coagulation, and natural antibodies. To persist in the host, pathogens, such as bacteria, viruses, and cancers must evade parts of the innate humoral immune system. Disruptions in the humoral innate immune system also play a role in the development of autoimmune diseases. This review will examine how gram positive bacteria, viruses, cancer, and the autoimmune conditions Systemic Lupus Erythematosus and Anti-phospholipid syndrome, interact with these immune system components. Through examining evasion techniques it becomes clear that interplay between these three systems exists. By exploring the interplay and the evasion/disruption of the humoral innate immune system, we can develop a better understanding of pathogenic infections, cancer, and autoimmune disease development.

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Humoral innate immune response and disease

Cited by 80 publications

References 202 publications

Bacterial Heterogeneity Is a Requirement for Host Superinfection by the Lyme Disease Spirochete

Bacterial Heterogeneity Is a Requirement for Host Superinfection by the Lyme Disease Spirochete

The porcine innate immune system: An update

Evasion and interactions of the humoral innate immune response in pathogen invasion, autoimmune disease, and cancer

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